Synthesis and Antimicrobial Activity of Some Novel Hydrazide, Pyrazole, Triazine, Isoxazole, and Pyrimidine Derivatives

Abstract

In continuation of our efforts to find a new class of antimicrobial agents, a series of pyrazole, 1,2,4‐triazine, isoxazole, pyrimidine, and other related products containing a hydrazide moiety were prepared via the reaction of 2‐cyano‐N‐((2‐methoxynaphthalen‐1‐yl)methylene) acetohydrazide (1) with appropriate chemical reagents. These compounds were evaluated for their antimicrobial activities, and also their minimum inhibitory concentration against most of test organisms was performed. Among the tested compounds 4, 5, 6, and 16 displayed excellent antimicrobial activity. All the synthesized products were confirmed by elemental analysis, IR, 1H‐NMR, 13C‐NMR, and mass spectral data.

Effectiveness of some novel heterocyclic compounds as corrosion inhibitors for carbon steel in 1 M HCl using practical and theoretical methods

“…11-13 illustrate FT-IR spectra of pure inhibitors liquid and the layer formed on carbon steel samples aer putting in 1.0 M HCl for a day in the presence of 20 Â 10 À6 M of (H4) when comparing the spectra of inhibitor solution with the spectra of the carbon steel surface aer immersion, the two spectra have the same properties, which mean that the compounds were adsorbed on the carbon steel surface. 18 The obtained results illustrate the mechanism of interference between (H4 & H5 & H6) and carbon steel surface. The shiing and missing in the spectra aer immersion showed that the interaction between (H4 & H5 & H6) and carbon steel surface was happened through functional groups mentioned in Table 9.…”

“…The investigated compounds were synthesized as described before 18,19 and are listed in Table 1. All the structures of the prepared compounds were elucidated by elemental analysis 1 H-NMR, 13C -NMR, and mass spectral data.…”

A Recent Update: Antimicrobial Agents Containing Pyrazole Nucleus

“…From in vitro test, it was found that compound (54-57) exhibited substantial inhibitory activity against bacterial strains with inhibition zone diameter within 15-24 mm. Refat and Fadda reported the synthesis and antimicrobial activity of some novel hydrazide, pyrazole, triazine, isoxazole, and pyrimidine derivatives [72]. Surprisingly, pyrazole (58) was denoted as the most potent compound within this research result.…”

“…A novel class of 3-(benzofuran-2-yl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole derivatives was designed by Rangaswamy et al [80]. Using well plate method for antimicrobial assay, compound (72) and (73) exhibited good inhibitory activity against E. coli, S. aureus, and P. aeruginosa.…”

Synthesis and insecticidal assessment of some innovative heterocycles incorporating a thiadiazole moiety against the cotton leafworm, Spodoptera littoralis

“…According to the MS of compound 12, the m/z was 371 corresponding to its molecular formula C 16 Next, the synthetic potency and applicability of cyanoacetamide derivative 1 were investigated to develop a facile and convenient route to some novel pyrazole and pyridine derivatives with an anticipated wide spectrum of bioresponses. 31,32 Thus, the Knoevenagel condensation of 1 with aromatic aldehydes, namely piperonal, vanilline, and 4-N,N-dimethylbenzaldehyde, in reuxing ethanol using piperidine as a basic catalyst afforded the corresponding arylidene derivatives 16a-c. Treatment of 16c with hydrazine hydrate in boiling ethanol yielded 3-amino- (17).…”