2011
DOI: 10.5155/eurjchem.2.1.65-69.303 View full text |Buy / Rent full text
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Abstract: KEYWORDSSome new pyrido [2,3-d]pyrimidine derivatives (3a-c) were synthesized from 2-amino-5-cyano-6-methoxy-4-(4-methoxyphenyl)pyridine-3-carboxamide.7-methoxy-5-(4-methoxy phenyl)-4-oxo-2-phenyl-3,4-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile (3b) and 7-methoxy-5-(4-methoxyphenyl)-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile (3c) are used in synthesizing 7a,b, then 8a,b. 7-methoxy-5-(4-methoxyphenyl)-2-methyl-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile (3a) and 4-hydrazinyl-7-methoxy… Show more

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“…[1][2][3][4][5][6][7][8][9][10][11][12][13] In addition, pyrido [2,3-d]pyrimidines exhibit antimicrobial, antifungal, and anti-inflammatory activities, [14][15][16] while thieno [2,3-d]pyrimidines exhibit antiproliferative and anti-inflammatory activities. Pyrimidines and their related fused heterocyclic derivatives possess antibacterial, antifungal, antiviral, anti-influenza, antioxidant, anti-inflammatory, antimalarial, antiproliferative, and antitumor activities.…”
Section: Introductionmentioning
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“…[1][2][3][4][5][6][7][8][9][10][11][12][13] In addition, pyrido [2,3-d]pyrimidines exhibit antimicrobial, antifungal, and anti-inflammatory activities, [14][15][16] while thieno [2,3-d]pyrimidines exhibit antiproliferative and anti-inflammatory activities. Pyrimidines and their related fused heterocyclic derivatives possess antibacterial, antifungal, antiviral, anti-influenza, antioxidant, anti-inflammatory, antimalarial, antiproliferative, and antitumor activities.…”
Section: Introductionmentioning
“…Among the heterocyclic compounds, pyridine and their analogues are the most prevalent structural units due to their wide spectrum of applications (Song, Huang, Yi, & Zhang, ), in natural products (Michael, ), pharmaceutical (Baumann & Baxendale, ; Vitaku, Smith, & Njardarson, ), agrochemical (Guan, Liu, Sun, & Xie, ) and material science (Desimoni, Faita, & Quadrelli, ; Gillissen et al., ). Many of the fused pyridine compounds have been proven as valuable candidates possessing anti‐bacterial (Elagamey, Sattar, El‐Taweel, & Said, ), anti‐fungal (Hanafy, ), anti‐microbial (Paresh & Yogesh, ), anti‐oxidant (Farghaly, Abass, Abdalla, & Mahgoub, ; Flefel et al., ), anti‐cancer (Bladt, Frisvad, Knudsen, & Larsen, ; Naresh Kumar et al., ), anti‐psychotic (Swain et al., ), anti‐inflammatory (Hend, At‐Allah, A‐Rahman, & El‐Gazza, ; Piero & Lucio, ), anti‐leishmanial (Samai, Nandi, Chowdhury, & Singh, ), anti‐viral (Tai et al., ), anti‐hypersensitive (Smith et al., ), anti‐convulsants (Kaminski, Obniska, Zagorska, & Maciag, ), anti‐malarial (Davoll, Clarke, & Elslage, ), potassium channel openers (Gadwood et al., ), anti‐diabetic (Sarges, Bordner, Dominy, Peterson, & Whipple, ) and anti‐tumour activities (Mohamed & Giuseppe, ). A few of previously reported bio‐active fused compounds ( A–D ) were represented in Figure .…”
Section: Introductionmentioning
“…Pyridopyrimidines and their intertwined heterocyclic ring frameworks are of current interest [ 1 4 ]. Pyrido[2,3- d ]pyrimidines are annulated uracil which, have gotten significant consideration over the last years because of their extensive variety of biological and pharmacological activities, such as anticancer [ 5 9 ], antimicrobial [ 10 , 11 ], antiviral [ 12 , 13 ], anti-inflammatory agents [ 14 ] antifolate [ 15 , 16 ], PDE IV inhibitors [ 17 ], and Inhibitors for hepatitis B virus [ 18 ]. Also, pyridopyrimidine moiety was considered as the best-known tyrosine kinase inhibitor for the treatment of endless myelogenous leukemia and medication resistance rises by enhancement of the improvement of a transformation [ 19 ].…”
Section: Introductionmentioning