Synthesis and antidepressant activity of some 1,3,5-triphenyl-2-pyrazolines and 3-(2″-hydroxy naphthalen-1″-yl)-1,5-diphenyl-2-pyrazolines

Prasad, Y. Rajendra; Rao, A. Lakshmana; Prasoona, L.; Murali, Karunanidhi; Kumar, Prasoon

doi:10.1016/j.bmcl.2005.08.040

Cited by 331 publications

(47 citation statements)

References 9 publications

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“…This activity was shown by many studies (Parmar et al, 1974;Soni et al, 1987;Turan-Zitouni et al, 2000;Palaska et al, 2001, Prasad et al, 2005. The earlier studies by Parmar et al and Soni et al showed that some substituted pyrazolines, such as 1,3,5-triphenyl-2-pyrazolines, which bear a cyclic hydrazine moiety, have monoamine oxidase (MAO) inhibitory properties in rat brain.…”

Section: Introductionmentioning

confidence: 82%

Evaluation of antidepressant-like effect of 2-pyrazoline derivatives

et al. 2009

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Many studies have shown that pyrazoline derivatives have therapeutic potential as antidepressant drugs. In this study, we aimed to investigate the antidepressant-like effect of eight new 1-[(N,N-disubstituted thiocarbamoylthio)acetyl]-3-(2-thienyl)-5-aryl-2-pyrazolines that have previously been synthesized in our laboratory. Antidepressant-like activity was investigated in mouse forced swimming test (FST). Drug-induced effects on motor function were also tested by using digitized motor activity monitoring system. Shortened immobility time in FST was accepted as indicator of antidepressant-like activity. Results showed that three of eight pyrazoline compounds (1b, 1d, 1g) significantly shortened immobility time compared with control. Compound 1b was found to be more effective in FST than were clomipramine and tranylcypromine, used as reference antidepressant drugs. This compound also significantly increased horizontal motor activity, like clomipramine, compared with control mice. These results suggest that the N,Ndisubstituted dithiocarbamate moiety of pyrazoline derivatives may have therapeutic antidepressant potential.

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Section: Introductionmentioning

confidence: 82%

Evaluation of antidepressant-like effect of 2-pyrazoline derivatives

et al. 2009

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“…In view of these observations and in continuation of our research program on the synthesis of chalcones and their derivatives 13,14 , like pyrimidines, pyrazolines and isoxazolines, we report here in the synthesis of some new pyrimidine derivatives which have been found to possess an interesting profile of anticancer activity.…”

Section: Introductionmentioning

confidence: 89%

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2011

IJPSR

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“…[2] Dihydropyrimidines have attracted considerable attention as they appeared of interest to possess wide range of therapeutic activities. Different activities are as under antiviral [3][4] antibacterial [5] , antitumor [6][7] , cardiovascular [8][9] , anticarcinogenic [10] , antihypertensive…”

Section: Introductionmentioning

confidence: 99%