Synthesis and antibacterial evaluation of Cu(II) and Zn(II) complexes of the β-lactum antibiotic, cefdinir

Sharma, Deepika; Kumar, Pradeep; Narasimhan, Balasubramanian

doi:10.1007/s00044-011-9588-2

Cited by 10 publications

(4 citation statements)

References 21 publications

(21 reference statements)

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“…The presence of metal ions in antibiotic metal complexes can lead to enhancement of their activity and a decrease of toxic properties. [6][7][8] One can use a broad set of different metals for complex formation with antibiotics, but not all of these complexes can possess antibacterial activity. For example, compounds of cefazolin (one of cephalosporins representatives) with Cr(III), Zn(II), Cd(II), Cu(II), Ni(II), Mn(II), Sn(II), Fe(III), Ag(I), synthesized earlier, have demonstrated antibacterial properties.…”

Section: Introductionmentioning

confidence: 99%

Complex Formation of Cefazolin with Ca²⁺ and Mg²⁺: Synthesis, DFT, Spectral and Antibacterial Determination

et al. 2021

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Mg(II) and Ca(II) complexes with cefazolin were synthesized and investigated using elemental and atomic-emission analysis, TGA, X-ray diffraction, FT-IR spectroscopy, 1 H and 13 CNMR, DFT calculations, and QTAIM analysis. The thermal behavior of these complexes was also studied. In the magnesium complex, two cefazolin ions are coordinated to the metal ion through the oxygen atoms of the lactam and carboxylate groups as a bidentate ligand. However, cefazolin chelated to the calcium ion through both oxygen atoms of the carboxylate groups and the lactam groups' oxygen atoms as tridentate ligand. Sodium cefazolin and metal complexes were also screened for antibacterial activity against Staphylococcus aureus and Escherichia coli. The calcium complex exhibited higher antibacterial effects than the magnesium complex (5.2-7.7 % higher against S. aureus-and 15.4-27.3 % against E. coli), which is related to weaker binding of Ca, compared to Mg, with the oxygen atom of lactam group and, as a result, more free releasing of the lactam group in the solving process.

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Section: Introductionmentioning

confidence: 99%

Complex Formation of Cefazolin with Ca²⁺ and Mg²⁺: Synthesis, DFT, Spectral and Antibacterial Determination

et al. 2021

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“…It is a low‐toxic transition metal ion and its abundance is next to iron in living body . Thus, Zn(II) ion plays an active role in biological system and Zn(II) based compounds are widely used as anti‐inflammatory and antibacterial agents …”

Section: Introductionmentioning

confidence: 99%

Fabrication of a Zn(II)‐Based 2D Pillar Bilayer Metal‐Organic Framework for Antimicrobial Activity

et al. 2019

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A Zn(II)-based two-dimensional (2D) pillar bilayer metal-organic framework (MOF) [{Zn(aip)(4,4'-bpy) 0.5 (MeOH)}⋅(H 2 O)] n (1), (H 2 aip = 5-aminoisophthalic acid and 4,4'-bpy = 4, 4'-bipyridine) has been designed and structurally characterized by single crystal X-ray diffraction (SCXRD) technique. Compound 1 exhibits considerable antibacterial activity upon Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), for which IC 50 values have been obtained as 86.26 � 1.2 μg/ml and 95.96 � 2.04 μg/ml respectively. Thus the fabricated MOF has the significant antibacterial property against pathogenic bacterial strains with significantly low IC 50 values. Therefore, the compound 1 deserves to be a Bio-MOF in the world of hybrid materials.[a] B.

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“…They are also employed as intermediates in chemical synthesis. Azetidinones are known to possess biological and therapeutic activities such as antibiotic, antidepressant, sedatives, anticancer, antibacterial, and antipyretic [2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Syntheses, Characterization, and Biological Activities of Metal Complexes of N-(2-Carbamoylthienyl)-C-(3′-carboxy-2′-hydroxyphenyl) Azetidin-2-one with Some Di-, Tetra-, and Hexavalent Metal Ions

Kumar¹,

Kumar²

2014

Journal of Chemistry

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The cyclization of the Schiff base, N-(2-carbamoylthienyl)-3′-carboxy-2′-hydroxybenzylideneimine with ClCH2COCl in dioxane, in the presence of triethylamine (Et3N) forms N-(2-carbamoylthienyl)-C-(3′-carboxy-2′-hydroxyphenyl) azetidin-2-one, LH3(I). A methanolic solution ofIreacts with Co(II), Cu(II), Zn(II), Zr(OH)2(IV), and MoO2(VI) ions and forms the coordination compounds, [Co(LH)(MeOH)]2(II), [Cu(LH)]2(III), [Zn(LH)(MeOH)2] (IV), [Zr(OH)2(LH)(MeOH)] (V), and [MoO2(LH)(MeOH)2] (VI). The compounds have been characterized on the basis of elemental analyses, molar conductance, molecular weight, spectral (IR, NMR, reflectance, and ESR) studies, and magnetic susceptibility measurements. All the coordination compounds are nonelectrolytes (ΛM=3.1-9.2 mho cm2mol−1) in DMF.Ibehaves as a dibasic tridentate OON donor ligand inV; a dibasic tetradentate OONO donor ligand inII,III, andVI; and a dibasic tetradentate OONS donor ligand inIV.IIandIIIare dimers, while others are monomers in diphenyl.IIIexhibits subnormal magnetic moment (1.55 B.M.) and is involved in antiferromagnetic exchange, while the other complexes are magnetically dilute. A square-pyramidal structure forIIIand an octahedral structure forII,IV, andVare suggested.VIexhibits an eight-coordinate structure. The ligand (I) and its compounds show antibacterial activities towardsE. coli(gram negative) andS. aureus(gram positive).

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Synthesis and antibacterial evaluation of Cu(II) and Zn(II) complexes of the β-lactum antibiotic, cefdinir

Cited by 10 publications

References 21 publications

Complex Formation of Cefazolin with Ca²⁺ and Mg²⁺: Synthesis, DFT, Spectral and Antibacterial Determination

Complex Formation of Cefazolin with Ca²⁺ and Mg²⁺: Synthesis, DFT, Spectral and Antibacterial Determination

Fabrication of a Zn(II)‐Based 2D Pillar Bilayer Metal‐Organic Framework for Antimicrobial Activity

Syntheses, Characterization, and Biological Activities of Metal Complexes of N-(2-Carbamoylthienyl)-C-(3′-carboxy-2′-hydroxyphenyl) Azetidin-2-one with Some Di-, Tetra-, and Hexavalent Metal Ions

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Synthesis and antibacterial evaluation of Cu(II) and Zn(II) complexes of the β-lactum antibiotic, cefdinir

Cited by 10 publications

References 21 publications

Complex Formation of Cefazolin with Ca2+ and Mg2+: Synthesis, DFT, Spectral and Antibacterial Determination

Complex Formation of Cefazolin with Ca2+ and Mg2+: Synthesis, DFT, Spectral and Antibacterial Determination

Fabrication of a Zn(II)‐Based 2D Pillar Bilayer Metal‐Organic Framework for Antimicrobial Activity

Syntheses, Characterization, and Biological Activities of Metal Complexes of N-(2-Carbamoylthienyl)-C-(3′-carboxy-2′-hydroxyphenyl) Azetidin-2-one with Some Di-, Tetra-, and Hexavalent Metal Ions

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Complex Formation of Cefazolin with Ca²⁺ and Mg²⁺: Synthesis, DFT, Spectral and Antibacterial Determination

Complex Formation of Cefazolin with Ca²⁺ and Mg²⁺: Synthesis, DFT, Spectral and Antibacterial Determination