Synthesis and anti-tuberculosis of Zn(II)Phenylalanine dithiocarbamate

Abstract

Tuberculosis (TB) is caused by the infection with the bacterium Mycobacterium tuberculosis (M.tb), and according to the World Health Organization, was responsible for 1.6 million deaths and the emergence of 9.6 million new cases in 2017. A serious problem worldwide in the fight against TB is the rapid spread of the multidrug-resistant (MDR) TB due to inconsistent for protracted periods of treatment and the lack of new drugs in the market. New and effective drugs are needed for the treatment of tuberculosis by studying the synthesis of complex compounds that can be developed as anti-tuberculosis agents. A new complexes of dithiocarbamate, Zn(II) phenylalanine dithiocarbamate ligand were synthesized using an ‘in situ’ method by reaction complexes in a 1:2 molar ratio in refluxing ethanol. The complexes were characterized by using Ultra Violet Visible (UV-Vis), Fourier Transform Infra Red (FT-IR), HNMR, XRD, conductivity, and melting point. Complex Zn(II) each of them is 260 nm and 431 nm electronic transition is π → π* of CS2 and N-C-S. Infra-Red absorption spectra at wave number Zn(II) phenylalanine dithiocarbamate is 372nm-1 coordination occurred dithiocarbamate ligands and atoms M=S. Complex characterization using UV-Vis, IR, and HNMR showed that complexes are successfully synthesis. The bio-assay results show these complexes are potential as anti-tuberculosis agents.

Design and Characterization of New Dinuclear Macrocyclic Dithiocarbamate Complexes by the Preparation of a Free Ligand Derived from Isopropylamine

“…The structural organization of the resulting metal complexes is determined by these binding properties [6]. Besides their complexation behavior, dithiocarbamates have myriad applications that range over a variety of scientific subjects, such as medicine [7,8], biological systems [9], materials science [10], and analytical chemistry [2], as well as industrial applications such as rubber vulcanization [11]. This property has encouraged a growing interest in their usage in environmental applications [12] and serving as herbicides [13] and fungicides [9] in agriculture.…”