Synthesis and anti-inflammatory evaluation of new chalcone derivatives bearing bispiperazine linker as IL-1β inhibitors

Small molecule compounds with good anti-inflammatory activity reported in the literature from 01/2009 to 05/2021: a review

“…The preliminary SAR analysis indicated that the type of bispiperazinochalcone derivatives influences the anti-inflammatory activities as well as the linkers of bispiperazine. Further, it was found that the amide linker of the compounds had an obvious influence on anti-inflammatory activities 50 .…”

Synthesis, cytotoxicity evaluation and molecular docking studies on 2′,4′-dihydroxy-6′-methoxy-3′,5′-dimethylchalcone derivatives

“… 22 Recently, the chalcone scaffold has attracted considerable interest from researchers in the field of drug discovery and development. 23 Chalcone derivatives exhibited a variety of pharmaceutical activities such as anti-inflammatory, 24 antiviral, antimalarial, antibacterial, anticancer, antifungal, antioxidant, anti-inflammation, anti-HIV-1 reverse transcriptase, tyrosinase inhibitor, anti-plasmodial, α-glucosidase inhibitory, and protein kinase C inhibitor effects. 25 In particular, metochalcone and sofalcone are clinically approved drugs for the treatment of choleretic and gastrointestinal diseases, respectively.…”

Isolation of oligostilbenes fromIris lacteaPall. var.chinensis(Fisch.) Koidz and their anti-inflammatory activities

“… 68 NO plays anti-inflammatory roles under normal physiological conditions, however, excessive production of NO has been found associated with various inflammatory disorders. 69 Therefore, we were investigated whether the four compounds affected NO production in LPS-stimulated RAW 264.7 cells. As shown in Fig.…”