Synthesis and anti-inflammatory activity of triazole-based macrocyclic amides through click chemistry

Anandhan, Ramasamy; Kannan, Ayyavoo; Rajakumar, Perumal

doi:10.1080/00397911.2016.1254800

Cited by 17 publications

(10 citation statements)

References 16 publications

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“…Anandhan et al prepared a series of triazole-based macrocyclic amides (7) via click chemistry using CuSO 4 (5 mol%), sodium ascorbate (10 mol %) in the presence of H 2 O/THF (1:1), RT. The synthesized compounds showed good antiinflammatory activity although at low concentration (50 μg/mL) in comparison to the reference drug prednisolone (Figure 7) [38].…”

Section: Metal-catalyzed Synthesis Of Triazole Derivativesmentioning

confidence: 98%

Role of Click Chemistry in Organic Synthesis

Sethiya¹,

Sahiba²,

Agarwal³

2021

Current Topics in Chirality - From Chemistry to Biology

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Click chemistry involves highly efficient organic reactions of two or more highly functionalized chemical entities under eco-benign conditions for the synthesis of different heterocycles. Several organic reactions such as nucleophilic ring-opening reactions, cyclo-additions, nucleophilic addition reactions, thiol-ene reactions, Diels Alder reactions, etc. are included in click reactions. These reactions have very important features i.e. high functional group tolerance, formation of a single product, high atom economy, high yielding, no need for column purification, etc. It also possesses several applications in drug discovery, supramolecular chemistry, material science, nanotechnology, etc. Being highly significant and valuable, we have elaborated on several aspects of click reactions in organic synthesis in this chapter. Recent advancements in the field of organic synthesis using click chemistry approach have been deliberated by citing last five years articles.

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Section: Metal-catalyzed Synthesis Of Triazole Derivativesmentioning

confidence: 98%

Role of Click Chemistry in Organic Synthesis

Sethiya¹,

Sahiba²,

Agarwal³

2021

Current Topics in Chirality - From Chemistry to Biology

View full text Add to dashboard Cite

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“…Anandhan et al [ 51 ] reported the synthesis of two triazole-based macrocyclic amides through click chemistry. They showed good anti-inflammatory activity even at low concentrations (50 µg/mL) when compared with that of the reference drug prednisolone.…”

Section: Synthesis Of 123 Triazolic Macrocyclesmentioning

confidence: 99%

Insights on the Synthesis of N-Heterocycles Containing Macrocycles and Their Complexion and Biological Properties

et al. 2022

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Macrocyclic chemistry has been extensively developed over the past several decades. In fact, the architecture of new macrocyclic models has undergone exponential growth to offer molecules with specific properties. In this context, an attempt is made in this study to provide an overview of some synthetic methods allowing the elaboration of N-heterocycles containing macrocycles (imidazole, triazole, tetrazole, and pyrazole), as well as their applications in the complexation of metal cations or as pharmacological agents.

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“…Synthetic polyazamacrocycles and their metal complexes have fostered a considerable research field at the interface between chemistry and biology due to their diverse biomedical [1,2,3,4,5,6,7,8], analytical [9], and industrial [10] applications. These physical, analytical, spectral, electrochemical, structural, and biological investigations attract attention owing to the elevated thermodynamic stability, kinetic inertness, and significant biological activities of the resultant species.…”

Section: Introductionmentioning

confidence: 99%

“…These physical, analytical, spectral, electrochemical, structural, and biological investigations attract attention owing to the elevated thermodynamic stability, kinetic inertness, and significant biological activities of the resultant species. The latter includes antibacterial [1], antifungal [1], antioxidant [2], anti-inflammatory [3], antidiabetic [4], and antiproliferative [5] activities. The superiority of synthetic macrocyclic complexes as antitumor [6], anticancer [7], and anti-HIV [8] agents is well documented.…”

Section: Introductionmentioning

confidence: 99%