Synthesis and activity of arylcoumarin derivatives with therapeutic effects on diabetic nephropathy
Yinbo Pan,
Min Zhou,
Zhenzhen Liu
et al.
Abstract:In the literature, daidzein has been reported to exhibit cardiovascular protective effects and hypoglycemic activity in mice. We sought to design and synthesize a novel compound, SJ‐6, an analog of daidzein, with improved hypoglycemic properties. Although SJ‐6 demonstrated favorable hypoglycemic effects, its pharmacokinetic limitations prompted us to design and synthesize prodrugs of SJ‐6. We conducted a comprehensive evaluation of the prodrugs, including in vitro and in vivo studies, such as cytotoxicity, abs… Show more
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