Syntheses of substituted 2,4-dioxo-thienopyrimidin-1-acetic acids and their evaluation as aldose reductase inhibitors

Synthesis of Some Thienopyrimidine Derivatives

“…Condensation of the amino esters 1a,c with ethyl chloroformate gave the carbamate derivatives 6a,b, which were fused with p-chlorobenzylamine at 230-240°C to afford the dione derivative 7 [16]. The thienopyrimidinone derivatives 8a,b were prepared by cyclization of the corresponding amino ester with formamide.…”

Synthesis and Antibacterial Activities of Novel 2,5-Diphenylindolo[2,3-e] Pyrazolo[1',5':3",4"]pyrimido[2",1"-c] [1,2,4]triazines

“…They also have considerable chemical and pharmacological importance; particularly, as nucleoside antibiotics, antibacterial, cardiovascular as well as agrochemical and veterinary products [1,2,3,4,5,6,7,8,9]. Various pyrimidine derivatives showed analgesic, antiarrhythmic, and anticancer activities [10,11,12], as well as anti-inflammatory, antiparkinsonian, and androgenic anabolic activities [13,14,15,16,17,18].…”

Synthesis of substituted 4-oxo-3,4-dihydro-thieno[3,4-d]pyrimidines and comparison of their properties with those of positionally isomeric thienopyrimidinones and benzo isosteres

“…For example, substances are known which possess potential anticancer [2][3][4] and vasodilator [5] properties, and aldose inhibitors of aldose reductase [6]. The representatives of this series which are under _______ * To whom correspondence should be addressed, e-mail: vkovtunenko@univ.kiev.ua, shura_zd@ukr.net.…”

“…Derivatives of system A have been studied far less than those of derivatives of systems B and C. According the date of Beilstein at the beginning of 2009 the number of references to compounds of series A, B, and C were in the ratio 1:100:40. However even the small number of publications indicates the wide pharmacological profile of derivatives of thieno [3,4-d]pyrimidin-4-one.For example, substances are known which possess potential anticancer [2-4] and vasodilator [5] properties, and aldose inhibitors of aldose reductase [6]. The representatives of this series which are under…”

“…For example, substances are known which possess potential anticancer [2-4] and vasodilator [5] properties, and aldose inhibitors of aldose reductase [6]. The representatives of this series which are under…”