Synovitis in Patients with Early Inflammatory Arthritis Monitored with Quantitative Analysis of Dynamic Contrast-enhanced Optical Imaging and MR Imaging

Meier, Reinhard; Thuermel, Klaus; Noël, Peter B.; Moog, Philipp; Sievert, Matti; Ahari, Carmen; Nasirudin, Radin A.; Golovko, Daniel; Haller, Bernhard; Ganter, Carl; Wildgruber, Moritz; Schaeffeler, Christoph; Waldt, Simone; Rummeny, Ernst J.

doi:10.1148/radiol.13130039

Cited by 48 publications

(43 citation statements)

References 47 publications

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“…Optical fluorescence imaging as a non-ionizing, fast, and costefficient imaging modality has also been considered in planar mode for the evaluation and monitoring of labelled cells [42,43]. However, planar imaging methods do not resolve fluorescence signals emanating from different depths, but instead deliver a weighted projection of the fluorochrome distribution, a fact that limits sensitivity and quantitative accuracy [44].…”

Section: Discussionmentioning

confidence: 99%

Fluorescence molecular tomography of DiR-labeled mesenchymal stem cell implants for osteochondral defect repair in rabbit knees

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Fluorescence molecular tomography of DiR-labeled mesenchymal stem cell implants for osteochondral defect repair in rabbit knees

et al. 2016

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“…Meier et al (95) published their work on use of dynamic contrastenhanced optical imaging to monitor therapy for inflammatory arthritis in Radiology in 2014. They showed that quantitative analysis of contrast-enhanced optical imaging enables potential therapeutic monitoring of synovitis in the hands of patients with inflammatory arthritis (95).…”

Section: Sodium Imagingmentioning

confidence: 99%

The Role ofRadiologyin the Evolution of the Understanding of Articular Disease

Huang

Schweitzer²

2014

Radiology

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Both the clinical practice of radiology and the journal Radiology have had an enormous effect on our understanding of articular disease. Early descriptions of osteoarthritis (OA) appeared in Radiology. More recently, advanced physiologic magnetic resonance (MR) techniques have furthered our understanding of the early prestructural changes in patients with OA. Sodium imaging, delayed gadolinium-enhanced MR imaging of cartilage, and spin-lattice relaxation in the rotating frame (or T1ρ) sequences have advanced understanding of the pathophysiology and pathoanatomy of OA. Many pioneering articles on rheumatoid arthritis (RA) also have been published in Radiology. In the intervening decades, our understanding of the natural history of RA has been altered by these articles. Many of the first descriptions of crystalline arthropathies, including gout, calcium pyrophosphate deposition, and hydroxyapatite deposition disease, appeared in Radiology.

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“…Since hypoxia affects both tissue blood content and oxygenation [22,24], near-infrared optical methods-diffuse optical spectroscopy (DOS) and tomography (DOT), and photoacoustic tomography (PAT)-that are sensitive to these physiological parameters are being developed to supplement/replace clinical assessment and radiology for RA monitoring [25][26][27][28][29][30][31][32][33][34]. These emerging techniques, DOS in particular, have the potential to overcome most of the limitations of current RA monitoring methods since they are safe, relatively inexpensive, and have the potential to quickly and objectively assess RA inflammation at the individual joint level [34,35]. Early applications were limited to measuring joint optical properties at a single wavelength and applying classification algorithms to distinguish inflamed from healthy joints [36][37][38].…”

Section: Introductionmentioning

confidence: 99%

Joint blood flow is more sensitive to inflammatory arthritis than oxyhemoglobin, deoxyhemoglobin, and oxygen saturation

Rajaram

Ioussoufovitch

Morrison

et al. 2016

Biomed. Opt. Express

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Joint hypoxia plays a central role in the progression and perpetuation of rheumatoid arthritis (RA). Thus, optical techniques that can measure surrogate markers of hypoxia such as blood flow, oxyhemoglobin, deoxyhemoglobin, and oxygen saturation are being developed to monitor RA. The purpose of the current study was to compare the sensitivity of these physiological parameters to arthritis. Experiments were conducted in a rabbit model of RA and the results revealed that joint blood flow was the most sensitive to arthritis and could detect a statistically significant difference (p<0.05, power = 0.8) between inflamed and healthy joints with a sample size of only four subjects. Considering that this a quantitative technique, the high sensitivity to arthritis suggests that joint perfusion has the potential to become a potent tool for monitoring disease progression and treatment response in RA.

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Synovitis in Patients with Early Inflammatory Arthritis Monitored with Quantitative Analysis of Dynamic Contrast-enhanced Optical Imaging and MR Imaging

Abstract: Quantitative analysis of contrast-enhanced optical imaging allows for potential therapeutic monitoring of synovitis in patients with inflammatory arthritis.

Cited by 48 publications

References 47 publications

Fluorescence molecular tomography of DiR-labeled mesenchymal stem cell implants for osteochondral defect repair in rabbit knees

Fluorescence molecular tomography of DiR-labeled mesenchymal stem cell implants for osteochondral defect repair in rabbit knees

The Role ofRadiologyin the Evolution of the Understanding of Articular Disease

Joint blood flow is more sensitive to inflammatory arthritis than oxyhemoglobin, deoxyhemoglobin, and oxygen saturation

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