Synovial sarcoma: cytopathology of 51 cases highlighting the application of ancillary molecular testing

Wakely, Paul E.; Saoud, Carla; Ali, Syed Z.

doi:10.1016/j.jasc.2023.04.003

Cited by 4 publications

(2 citation statements)

References 67 publications

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“…(1) Fine‐needle aspiration, which has been reported to be a reliable tool for the specific diagnosis of SS. When combined with the auxiliary molecule SS18 test, an accuracy of close to 100% was achieved 10 . (2) Immunohistochemistry shows that monophasic subtypes can be mixed with other types of sarcomas; therefore, immunohistochemistry is crucial for differential diagnosis and can be used to confirm the diagnosis 6 .…”

Section: Discussionmentioning

confidence: 99%

“…When combined with the auxiliary molecule SS18 test, an accuracy of close to 100% was achieved. 10 (2) Immunohistochemistry shows that monophasic subtypes can be mixed with other types of sarcomas; therefore, immunohistochemistry is crucial for differential diagnosis and can be used to confirm the diagnosis. 6 (3) PPSS is usually positive for cytokeratin, EMA, BCL-2, Vimentin, CD56 and CD99, TLE1, AE1\/AE3, CK7, and SMA, 6,11 and negative for S-100 and Desmin.…”

Section: Discussionmentioning

confidence: 99%

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Primary pulmonary monophasic synovial sarcoma initially presenting with bloody pleural effusion: A case report and literature review

Yin,

Liu,

Xue

et al. 2024

Clinical Case Reports

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Key Clinical MessagePrimary pulmonary synovial sarcoma (PPSS) can originate from blood vessels of the bronchial wall, lung interstitium, and interstitial components, and accounts for 0.1%–0.5% of all primary lung malignancies, the most common symptoms are chest pain, cough, dyspnea, and hemoptysis.AbstractSynovial sarcoma (SS) is a rare malignant tumor of stromal origin, which accounts for approximately 8%–10% of all soft tissue sarcomas. Primary pulmonary synovial sarcoma (PPSS) can originate from blood vessels of the bronchial wall, lung interstitium, and interstitial components, and accounts for 0.1%–0.5% of all primary lung malignancies. Patient concerns: We report the first case of a 57‐year‐old man with bloody pleural effusion as an initial manifestation of PPSS in the middle lobe of the right lung diagnosed after surgery. Diagnosis: Chest computed tomography (CT) revealed a mass in the middle lobe of the right lung, which was pathologically diagnosed as a monophasic SS after surgical resection. Interventions: Ten days after preoperative closed chest drainage, a right thoracotomy was performed to remove the right middle lobe of the lung. Outcomes: The patient recovered smoothly and was discharged from the hospital without any other postoperative treatment. A follow‐up chest CT scan 7 months postoperatively revealed intrapulmonary recurrence with multiple metastases. Lessons: Monophasic PPSS of the lung may present with bloody pleural effusion as its first manifestation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Primary pulmonary monophasic synovial sarcoma initially presenting with bloody pleural effusion: A case report and literature review

Yin,

Liu,

Xue

et al. 2024

Clinical Case Reports

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Soft Tissue Fine-Needle Aspiration

Lajara,

2024

Surgical Pathology Clinics

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Combined fine needle aspiration cytology and core needle biopsy in the same setting: A two‐years’ experience

Ciliberti,

Maffei,

D'Ardia

et al. 2023

Cytopathology

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IntroductionFine needle aspiration cytology (FNAC) combined with rapid on‐site evaluation (ROSE) and ancillary techniques is an accurate diagnostic tool for many pathologies. However, in some cases, it may not be sufficient for actionable diagnoses or molecular testing, especially for cases that require large immunohistochemical panels or cases in which histological features are mandatory for the diagnosis. Core needle biopsy (CNB), on the contrary, provides samples that are suitable for histological features and sufficient for all ancillary studies. However, CNB is often performed by radiologists or clinicians without the direct participation of cytopathologists, which can lead to missed or delayed diagnoses. This study reports on the experience of combining FNAC and CNB performed in one setting by cytopathologists. The aim was to evaluate the impact of CNB on FNAC and the diagnostic efficiency of the combined procedures.Materials and MethodsOne hundred forty‐two FNAC and CNB procedures performed in the same setting over a period of 2 years were analysed. The FNAC diagnoses were compared and integrated with the subsequent CNB diagnoses. The impact of CNB was categorized as follows: non‐contributory, in cases of inadequate samples; confirmed, when the CNB and FNAC diagnoses were the same; improved, when the CNB diagnosis was consistent with the FNAC diagnosis and further specified the corresponding entity; allowed, when CNB produced a diagnosis that could not be reached by FNAC; changed, when the CNB changed the previous FNAC diagnosis.ResultsCNB confirmed the FNAC diagnosis in 40.1% of cases (n = 57/142). CNB improved the FNAC diagnosis in 47.2% of cases (n = 67/142). CNB allowed a diagnosis that could not be performed on FNAC in 2.1% of cases (n = 3/142). CNB changed a previous FNAC diagnosis in 2.1% of cases (n = 3/142). CNB was non‐contributory in 8.4% of cases (n = 12/142). CNB produced a positive impact on the whole diagnostic procedure in 51.4% of total cases (n = 73/142). The combined FNAC and CNB resulted in actionable diagnoses in 91.5% of all cases (n = 130/142). A complete molecular assessment was successfully performed in 14.7% of cases (n = 21/142) utilizing either FNAC or CNB material.ConclusionsThe combined use of FNAC and CNB in one setting improves the diagnostic accuracy of both procedures. This approach exploits the advantages of each procedure, enhancing the accuracy of the final diagnosis.

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Synovial sarcoma: cytopathology of 51 cases highlighting the application of ancillary molecular testing

Cited by 4 publications

References 67 publications

Primary pulmonary monophasic synovial sarcoma initially presenting with bloody pleural effusion: A case report and literature review

Primary pulmonary monophasic synovial sarcoma initially presenting with bloody pleural effusion: A case report and literature review

Soft Tissue Fine-Needle Aspiration

Combined fine needle aspiration cytology and core needle biopsy in the same setting: A two‐years’ experience

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