Synovial mesenchymal stem cell-derived exosomal miR-485-3p relieves cartilage damage in osteoarthritis by targeting the NRP1-mediated PI3K/Akt pathway

Additional comments on extracellular vesicles derived from mesenchymal stem cells mediate extracellular matrix remodeling in osteoarthritis

“…Qian et al [ 7 ] found that exosomal miR-26b-5p can transform pro-inflammatory M1 macrophages into anti-inflammatory M2 types by targeting the toll-like receptor 3 signaling pathway to alleviate OA. Additionally, Qiu et al [ 8 ] found that exosomal miR-485-3p can alleviate cartilage damage in OA by targeting the NRP1-mediated PI3K/Akt pathway. Furthermore, researchers integrated the less commonly used miR-29a into exosomes, presenting a new approach for treating OA.…”