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Cited by 10 publications
(14 citation statements)
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References 8 publications
(9 reference statements)
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“…The antitumor activity of cytotoxic T cells can be observed in the non-irradiated field. Such Abscopal responses can be achieved by irradiating either primary or metastatic tumors [13][14][15][16][17][18].…”
Section: Discussionmentioning
confidence: 99%
“…The antitumor activity of cytotoxic T cells can be observed in the non-irradiated field. Such Abscopal responses can be achieved by irradiating either primary or metastatic tumors [13][14][15][16][17][18].…”
Section: Discussionmentioning
confidence: 99%
“…28 The mechanisms driving the synergistic effect between radiotherapy and checkpoint inhibition are a topic of active investigation and continue to be elucidated. 9,10,29 Nevertheless, the present study contributes understanding of how mdSBRT influences CD8 + T-cell immunophenotypic changes and how such changes are associated with clinical outcomes. These T TR cells’ function and associated disease control could, in theory, be further potentiated by anti-PD-1 therapy in addition to their clonal expansion.…”
Section: Discussionmentioning
confidence: 83%
“…In one case, anti-MAGEA3 antibodies were found on serologic testing, revealing an association between the abscopal effect and a systemic antitumor immune response [ 42 ]. Radiotherapy has the potential to overcome numerous mechanisms of tumor immune evasion and also produce tumor specific cytotoxic T-cells [ 43 , 44 ]. Radiotherapy has also been shown to increase the expression of PD-L1 on tumor cells [ 45 ].…”
Section: Future Horizonsmentioning
confidence: 99%