Synergy between surfactants and mucoadhesive polymers enhances the transbuccal permeation of local anesthetics from freeze-dried tablets

Favacho, Hugo Alexandre Silva; Couto, Renê Oliveira do; Duarte, Maíra Peres Ferreira; Peixoto, Maria Paula Garofo; Lopez, Renata Fonseca Vianna; Pedrazzi, Vinícius; Gaitani, Cristiane Masetto de; Freitas, Osvaldo de

doi:10.1016/j.msec.2019.110373

Cited by 14 publications

(12 citation statements)

References 39 publications

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“…These hydrophilic macromolecules contain hydrogen bond forming groups, thus favoring the adhesion to the buccal mucosa [39][40][41]. Propylene glycol was incorporated in the liquid ink as viscosity modifier, and has been reported to enhance the permeation and adhesion properties of buccal films [8,9,42]. Solubility studies, surface tension, and viscosity measurements were performed to determine the optimal liquid ink.…”

Section: Introductionmentioning

confidence: 99%

Development and Characterization of Inkjet Printed Edible Films for Buccal Delivery of B-Complex Vitamins

et al. 2020

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Buccal films containing two vitamins, i.e., thiamine hydrochloride (THCl) and nicotinic acid (NA), were fabricated via two-dimensional (2D) inkjet printing. For the preparation of buccal films, solubility studies and rheological evaluations were conducted in distilled water and propylene-glycol (PG) as main solvent and viscosity/surface tension modifier, respectively. The increased solubility in the solvents’ mixture indicated that manufacturing of several doses of the THCl and NA is achievable. Various doses were deposited onto sugar-sheet substrates, by increasing the number of printing passes. The physiochemical characterization (SEM, DSC, FTIR) revealed that inkjet printing does not affect the solid state of the matrix. Water uptake studies were conducted, to compare the different vitamin-loaded formulations. The in vitro release studies indicated the burst release of both vitamins within 10 min, a preferable feature for buccal administration. The in vitro permeation studies indicated that higher concentrations of the vitamins onto the sugar sheet improved the in vitro permeation performance of printed formulations.

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Section: Introductionmentioning

confidence: 99%

Development and Characterization of Inkjet Printed Edible Films for Buccal Delivery of B-Complex Vitamins

et al. 2020

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“…The plasticizing effect of the deposited PG molecules was evidenced by the significant reduction in EM and the increase in flexibility of the inkjet-printed films, compared to the plain 3D-printed specimen. This effect further enhanced the mucoadhesive properties of HPMC, 49 by facilitating the entanglement of the HPMC chains with the mucosa, 46 as it was evidenced by the increased F max and W ad values of the inkjet-printed films.…”

Section: Discussionmentioning

confidence: 92%

“…This behavior is preferable for the prompt management of local pain, immediately after the application of the film to the buccal site. 30,49 Although the incorporation of the backing layer did not affect the release behavior of LiH, the unidirectional buccal release of local anesthetics is crucial. Considering special populations, e.g., children, the accidental swallowing of lidocaine has been reported by the US Food and Drug Administration (FDA) to result in seizures, severe brain injuries, heart-related problems, or even death.…”

Section: Discussionmentioning

confidence: 99%

Fabrication of Mucoadhesive Buccal Films for Local Administration of Ketoprofen and Lidocaine Hydrochloride by Combining Fused Deposition Modeling and Inkjet Printing

Eleftheriadis

Monou

Bouropoulos

et al. 2020

Journal of Pharmaceutical Sciences

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“…Patient acceptability has been one of the major advantages of buccal/sublingual mucosae apart from the technical advantage of bypassing the first-pass metabolism. Various formulations such as mucoadhesive tablets, sprays, gels, and patches have been formulated to date (Barua et al, 2016;Mura, Cirri, Mennini, Casella, & Maestrelli, 2016). The most recent work on mucoadhesive buccal tablets reports freeze-dried formulations for prilocaine and lidocaine as local anesthetics for dental procedures (Favacho et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

“…Various formulations such as mucoadhesive tablets, sprays, gels, and patches have been formulated to date (Barua et al, 2016;Mura, Cirri, Mennini, Casella, & Maestrelli, 2016). The most recent work on mucoadhesive buccal tablets reports freeze-dried formulations for prilocaine and lidocaine as local anesthetics for dental procedures (Favacho et al, 2020). Mucoadhesive polymers have been the mainstay of drug delivery formulation through mucosal routes.…”

Section: Introductionmentioning

confidence: 99%

In vitro characterization of mucoadhesive polysaccharide polymers tablets fabricated using FTIR press

Kumar¹,

Bharti²,

Kumar³

2020

IJP

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Background and Aim: Buccal/sublingual drug delivery is gradually becoming one of the most experimented routes for alternate drug delivery. The major advantage of both routes is their high vascularity that allows a substantial permeation of drugs into systemic circulation. Mucoadhesive biopolymers are the mainstay of a transmucosal drug delivery system. Methods: We formulated blank tablets of explored mucoadhesive biopolymers (sodium alginate, carboxymethyl cellulose, hydroxyl propyl methyl) cellulose using a combination of two at a time. The novelty of this script lies in the formation of tablets using the FTIR hydraulic press, as opposed toa conventional tablet punching machine, at two different pressures. The tablets were subjected to basic characterizations of polymeric interaction, hardness, and swelling behaviour. Results: An interaction analysis using XRD revealed a good interaction between the polymers. HC-300 and AC-300 were found to be the hardest among the tablets formulated. In terms of swelling behaviour, AC-200 and HA-300 displayed the best swelling as compared to other combinations. Conclusion: In the absence of a conventional tablet punching machine, we fabricated swellable biopolymeric tablets using the regular KBr hydraulic press that comes as an accessory with the FTIR instrument. These tablets can possible be used for delivering drugs through buccal mucosa.

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Synergy between surfactants and mucoadhesive polymers enhances the transbuccal permeation of local anesthetics from freeze-dried tablets

Cited by 14 publications

References 39 publications

Development and Characterization of Inkjet Printed Edible Films for Buccal Delivery of B-Complex Vitamins

Development and Characterization of Inkjet Printed Edible Films for Buccal Delivery of B-Complex Vitamins

Fabrication of Mucoadhesive Buccal Films for Local Administration of Ketoprofen and Lidocaine Hydrochloride by Combining Fused Deposition Modeling and Inkjet Printing

In vitro characterization of mucoadhesive polysaccharide polymers tablets fabricated using FTIR press

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