Synergy between Indoloquinolines and Ciprofloxacin: An Antibiofilm Strategy against Pseudomonas aeruginosa

Abstract

Antibiotic treatments can participate in the formation of bacterial biofilm in case of under dosage. The interest of indoloquinoline scaffold for drug discovery incited us to study the preparation of new indolo [2,3-b]quinoline derivatives by a domino radical process. We tested the effect of two different “indoloquinoline” molecules (Indol-1 and Indol-2) without antimicrobial activity, in addition to ciprofloxacin, on biofilm formation thanks to crystal violet staining and enumeration of adhered bacteria. This association of ciprofloxacin and Indol-1 or Indol-2 attenuated the formation of biofilm up to almost 80% compared to ciprofloxacin alone, or even prevented the presence of adhered bacteria. In conclusion, these data prove that the association of non-antimicrobial molecules with an antibiotic can be a solution to fight against biofilm and antibiotic resistance emergence.

Efficacy of boric acid therapy in a pseudomonas aeruginosa-induced chronic otitis media model in rats

“…Other research recommended that floroquinolones should not be used as first-line treatment in COM 7 . Additional therapeutic alternatives are therefore needed, in addition to ciprofloxacin, described as the most important and effective agent in P. aeruginosa infections 11 . Both 4% and 8% BA were found to be effective against P. aeruginosa in the present study.…”

“…Systemic antibiotics are also used in COM in case of unsuccessful treatment or intracranial compression 7 . Ciprofloxacin is the most effective and important of the systemic antibiotics against P. aeruginosa infections 9,11 .…”

Synergistically enhanced photothermal transition of a polyoxometalate/peptide assembly improved the antibiofilm and antibacterial activities

“…3–5 As a self-generated extracellular matrix on healthy bacterial cells the biofilm endows the pathogenic bacteria with more persistence in the host environment, 6,7 the resulted drug resistance to antibiotics should be solved. Therefore, it is of great importance and significance to develop novel antibiofilm strategies 8 and new materials. 9 Over the past decades, beyond pursuing highly efficient antibacterial materials, antibiotic-independent strategies, such as photodynamic therapy (PDT) and photothermal therapy (PTT), have been developed accordingly.…”