Synergistic suppression effect on tumor growth of ovarian cancer by combining cisplatin with a manganese superoxide dismutase-armed oncolytic adenovirus

Wang, Shibing; Shu, Jing; Chen, Long Qing; Chen, Xiaopan; Zhao, Jianhong; Li, Shuangshuang; Mou, Xiaozhou; Tong, Xiangmin

doi:10.2147/ott.s113014

Cited by 15 publications

(13 citation statements)

References 21 publications

(20 reference statements)

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“…The ideal combination treatment should reduce toxicity and increase the therapeutic effect. Some clinical studies have shown that a good antitumor ability, reduced toxicity, and increased treatment effect could be exerted by combining oncolytic adenovirus with a chemotherapy drug such as cisplatin ( 17 , 18 ).…”

Section: Discussionmentioning

confidence: 99%

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Synergistic antitumor effect of the combination of a dual cancer‑specific oncolytic adenovirus and cisplatin on lung cancer cells

et al. 2018

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The effect of the combination of a recombinant adenovirus (ATV) expressing a specific apoptin protein and cisplatin on human lung cancer cells (A549 cells) was determined. The inhibitory effects of ATV and cisplatin, ATV alone, or cisplatin alone on the migration and invasion of A549 cells were evaluated in vitro using cell proliferation, wound healing, Transwell migration and Matrigel invasion assays. The tumor inhibition effect on A549 cells in vivo was assessed by observing the tumor growth and survival rate of nude mice with subcutaneous tumor xenografts grown from implanted A549 cells after treatment with ATV, cisplatin, or ATV combined with cisplatin. The proliferation (P<0.01), migration (P<0.01), and invasion (P<0.01) on A549 cells was suppressed significantly by ATV, cisplatin, and ATV and cisplatin, in a dose- and time-dependent manner. The inhibition of tumor growth in transplanted nude mice in the ATV combined with cisplatin group was significantly higher than that displayed in the other groups, and the survival rate of the combined treatment group was significantly higher than that of the group treated with cisplatin alone. The results indicated that the combined application of ATV and cisplatin could reduce toxicity and showed a synergistic effect in reducing tumor growth and increasing survival. Thus, there is a potential research value in treating tumors using the combination of ATV and cisplatin, which provides a foundation for future preclinical studies on this antitumor treatment.

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Section: Discussionmentioning

confidence: 99%

“…The human adenovirus serotype 5 (Ad5) is one of such vector that has been used widely to treat a variety of tumors ( 13 – 16 ). In addition, satisfactory curative effects in the treatment of tumors have been demonstrated by a combination of a recombinant Ad5 and cisplatin ( 17 , 18 ).…”

Section: Introductionmentioning

confidence: 99%

Synergistic antitumor effect of the combination of a dual cancer‑specific oncolytic adenovirus and cisplatin on lung cancer cells

et al. 2018

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“…Some reports have classified SOD2 as a tumor suppressor due to its lower expression in some cancers 16‐18 . For example, the combination of SOD2 and cisplatin significantly inhibited ovarian tumor growth by inducing apoptosis 19 . In hepatoma cells, inhibition of SOD2 promoted tumorigenesis and produced a more malignant phenotype with metabolic transformation via a reduction β‐catenin and hypoxia‐inducible factor‐1α 20 .…”

Section: Introductionmentioning

confidence: 99%

“…[16][17][18] For example, the combination of SOD2 and cisplatin significantly inhibited ovarian tumor growth by inducing apoptosis. 19 In hepatoma cells, inhibition of SOD2 promoted tumorigenesis and produced a more malignant phenotype with metabolic transformation via a reduction β-catenin and hypoxia-inducible factor-1α. 20 Serum expression of hepatocarcinogenesis markers was enhanced in mice deficient for hepatocyte-specific SOD2.…”

Section: Introductionmentioning

confidence: 99%

Redox regulation by SOD2 modulates colorectal cancer tumorigenesis through AMPK‐mediated energy metabolism

Zhou

Lyu

Miao

et al. 2020

Molecular Carcinogenesis

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Colorectal cancer (CRC) is a common malignancy. Many reports have implicated aberrant mitochondrial activity in the progression of CRC, with particular emphasis on the dysregulation of redox signaling and oxidative stress. In this study, we focused on manganese superoxide dismutase (MnSOD/SOD2), a key antioxidant enzyme, which maintains intracellular redox homeostasis. Current literature presents conflicting mechanisms for how SOD2 influences tumorigenesis and tumor progression. Here, we explored the role of SOD2 in CRC specifically. We found high levels of SOD2 expression in CRC tissues. We carried out a series of experiments to determine whether knockdown of SOD2 expression in CRC cell lines would reverse features of tumorigenesis. We found that reduced SOD2 expression decreased cell proliferation, migration, and invasion activity in CRC cells. Results from an additional series of experiments on mitochondrial function implicated a dual role for SOD2 in promoting CRC progression. First, proper level of SOD2 helped CRC cells maintain mitochondrial function by disposal of superoxide (O2.−). Second, over‐expression of SOD2 induced H2O2‐mediated tumorigenesis by upregulating AMPK and glycolysis. Our results indicate that SOD2 may promote the occurrence and development of CRC by regulating the energy metabolism mediated by AMPK signaling pathways.

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“…For this reason, sTRAIL has been extensively used in OAds [66,[87][88][89][90][91]. Different transgenes that induce late apoptosis have been reported [66,[92][93][94][95].…”

Section: Virocentric Transgenesmentioning

confidence: 99%

Effect of Transgene Location, Transcriptional Control Elements and Transgene Features in Armed Oncolytic Adenoviruses

Farrera-Sal¹,

Fillat

Alemany

2020

Cancers

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Clinical results with oncolytic adenoviruses (OAds) used as antitumor monotherapies show limited efficacy. To increase OAd potency, transgenes have been inserted into their genome, a strategy known as "arming OAds". Here, we review different parameters that affect the outcome of armed OAds. Recombinant adenovirus used in gene therapy and vaccination have been the basis for the design of armed OAds. Hence, early region 1 (E1) and early region 3 (E3) have been the most commonly used transgene insertion sites, along with partially or complete E3 deletions. Besides transgene location and orientation, transcriptional control elements, transgene function, either virocentric or immunocentric, and even the codons encoding it, greatly impact on transgene levels and virus fitness.

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Synergistic suppression effect on tumor growth of ovarian cancer by combining cisplatin with a manganese superoxide dismutase-armed oncolytic adenovirus

Cited by 15 publications

References 21 publications

Synergistic antitumor effect of the combination of a dual cancer‑specific oncolytic adenovirus and cisplatin on lung cancer cells

Synergistic antitumor effect of the combination of a dual cancer‑specific oncolytic adenovirus and cisplatin on lung cancer cells

Redox regulation by SOD2 modulates colorectal cancer tumorigenesis through AMPK‐mediated energy metabolism

Effect of Transgene Location, Transcriptional Control Elements and Transgene Features in Armed Oncolytic Adenoviruses

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