Synergistic Nanozymetic Activity of Hybrid Gold Bipyramid–Molybdenum Disulfide Core@Shell Nanostructures for Two-Photon Imaging and Anticancer Therapy

Abstract

In recent years, the concept of combined therapy using gold hybrid nanomaterials has been broadly adopted to pioneer new anticancer treatments. However, their synergistic anticancer effects have yet to be thoroughly investigated. Herein,a hybrid gold nanobipyramid nanostructure coated with molybdenum disulfide (MoS2) semiconductor (AuNBPs@MoS2) was proposed as a smart nanozyme for anticancer therapy and two-photon bioimaging. The hybrid material showed dramatically enhanced localized surface plasmon resonance property under excitation owing to its anisotropic nature, coupled with the rich electron density in MoS2, resulting in the superior in situ photogeneration of reactive oxidative species (ROS - 1O2, •OH). We demonstrated that the synergistic effect of enhanced photothermal conversion and generation of ROS could increase the anticancer effect of AuNBPs@MoS2. Two-photon luminescence imaging confirmed that AuNBPs@MoS2 was successfully internalized in cancer cells and that simultaneous anticancer treatments based on catalytic and photothermal therapy could be achieved. This study highlighted, for the first time, a novel approach of plasmon-mediated powerful anticancer therapy and imaging via the unprecedented combination of anisotropic AuNBPs and two-dimensional MoS2 material.

Nonspherical Metal‐Based Nanoarchitectures: Synthesis and Impact of Size, Shape, and Composition on Their Biological Activity

“…Reproduced with permission. [ 29 ] Copyright 2018, American Chemical Society. E) Au nanorods synthesized by seed‐mediated growth.…”

<p>Nanomaterial-Based Tumor Photothermal Immunotherapy</p>

“…[94][95][96] Nanomaterials with a photothermal effects are widely used to enhance PTT and have achieved encouraging therapeutic results. 97 Photothermal agents mainly include gold nanomaterials, like GNShs, GNRs, GNCs, GNSs; 39-50 carbon nanomaterials such as SWCNTs, graphene, fullerene, 51-56,98-100 semiconductor nanomaterials such as MoS 2 , WS 2 , Bi 2 Se 3 ; [60][61][62][101][102][103][104] organic NIR dyes such as IGC, IR780, IR820 ( Figure 1B). [63][64][65][66][67][68][69][70][71][72][73][74] However, there are still some ambiguity in PTT.…”

“…Interestingly, recent revisions have shown that hyperthermia can induce dying tumor cells to release antigens, pro-inflammatory cytokines, and immunogenic intracellular substrates, thus promoting immune activation. Nanomaterials with a photothermal effects are widely used to enhance PTT, including gold nanoparticles such as gold nanoshells (GNShs), 39-41 gold nanorods (GNRs), [42][43][44] gold nanocages (GNCs), [45][46][47] gold nanostars (GNSs), 48-50 carbon nanomaterials, such as single-walled carbon nanotubes (SWCNTs), [51][52][53] graphene; [54][55][56] semiconductor nanoparticles, such as copper sulfide (CuS), [57][58][59] molybdenum disulfide (MoS 2 ) [60][61][62] organic NIR dyes such as indocyanine green (IGC), [63][64][65][66][67][68] IR780, 69-71 IR820 [72][73][74] as well as other PTT nanomaterials. In addition to direct killing effect, it is recognized that a key role caused by PTT is immunogenic cell death (ICD).…”

Computed tomography and photoacoustic imaging guided photodynamic therapy against breast cancer based on mesoporous platinum with insitu oxygen generation ability

“…A variety of strategies have been developed to treat tumor hypoxia and improve the efficacy of PDT 7 , 8 , including hyperbaric oxygen therapy 9 , antitumor angiogenesis therapy 10 , biological reduction therapy 11 , and oxygen transport or generation via nanomaterials 12 , 13 . Recently, an in situ catalytic strategy using nanomaterials to overcome tumor hypoxia has become one of the most promising research directions 14 , 15 , 16 . One in situ catalytic nanomaterial, manganese oxide (MnO 2 ), can decompose to produce oxygen in the acidic environment of the tumor to improve the efficiency of PDT, but the synthesis procedures are complex 17 , 18 , 19 .…”