Synergistic Effects of Surface Chemistry and Topologic Structure from Modified Microarc Oxidation Coatings on Ti Implants for Improving Osseointegration

Zhou, Rui; Wei, Daqing; Cao, Jianyun; Feng, Wei; Cheng, Su; Du, Qing; Li, Baoqiang; Wang, Yaming; Jia, Dechang; Zhou, Yu

doi:10.1021/acsami.5b02226

Cited by 75 publications

(51 citation statements)

References 56 publications

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“…The biomaterial surface properties of an implanted medical device have demonstrated to contribute to the host cellular and tissue responses and play a significant role in determining the overall implant success or failure. 9 , 10 Therefore, manipulating the surface physical or chemical properties offers an effective and straightforward strategy to improve the biological performance of implant materials. For titanium implants installed in bone defects in animal studies, multiple studies have shown superior bone-to-implant contact and peri-implant bone formation when the surface roughness (arithmetical mean deviation of the surface profile, R a ) is between 1 and 1.5 μm.…”

Section: Introductionmentioning

confidence: 99%

Combinatorial Surface Roughness Effects on Osteoclastogenesis and Osteogenesis

Zhang

Chen

Shao

et al. 2018

ACS Appl. Mater. Interfaces

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Implant surface properties are a key factor in bone responses to metallic bone implants. In view of the emerging evidence on the important role of osteoclasts in bone regeneration, we here studied how surface roughness affects osteoclastic differentiation and to what extent these osteoclasts have stimulatory effects on osteogenic differentiation of osteoprogenitor cells. For this, we induced osteoclasts derived from RAW264.7 cell line and primary mouse macrophages on titanium surfaces with different roughness (Ra 0.02–3.63 μm) and analyzed osteoclast behavior in terms of cell number, morphology, differentiation, and further anabolic effect on osteoblastic cells. Surfaces with different roughness induced the formation of osteoclasts with distinct phenotypes, based on total osteoclast numbers, morphology, size, cytoskeletal organization, nuclearity, and osteoclastic features. Furthermore, these different osteoclast phenotypes displayed differential anabolic effects toward the osteogenic differentiation of osteoblastic cells, for which the clastokine CTHRC1 was identified as a causative factor. Morphologically, osteoclast potency to stimulate osteogenic differentiation of osteoblastic cells was found to logarithmically correlate with the nuclei number per osteoclast. Our results demonstrate the existence of a combinatorial effect of surface roughness, osteoclastogenesis, and osteogenic differentiation. These insights open up a new dimension for designing and producing metallic implants by considering the implant roughness to locally regulate osseointegration through coupling osteoclastogenesis with osteogenesis.

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Section: Introductionmentioning

confidence: 99%

Combinatorial Surface Roughness Effects on Osteoclastogenesis and Osteogenesis

Zhang

Chen

Shao

et al. 2018

ACS Appl. Mater. Interfaces

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“…Material and device design explored together yielded a breakthrough advancement in the form of hydroxyapatite (HA) through a myriad of device designs beyond the scope of this manuscript (Barber et al, 1998; Facca et al, 2011; McAfee et al, 2003; Nepal et al, 2014; Salou et al, 2015; Sandén et al, 2002; Spivak and Hasharoni, 2001; Yerby et al, 1998; Yildirim et al, 2006; Zhou et al, 2014, 2015). The subject of improving osseointegration following initial surgical placement is paramount as it will ensure long lasting surgical hardware stability.…”

Section: Introductionmentioning

confidence: 99%

Osseodensification for enhancement of spinal surgical hardware fixation

Lopez

Alifarag

Torroni

et al. 2017

Journal of the Mechanical Behavior of Biomedical Materials

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Integration between implant and bone is an essential concept for osseous healing requiring hardware placement. A novel approach to hardware implantation, termed osseodensification, is described here as an effective alternative. 12 sheep averaging 65 kg had fixation devices installed in their C2, C3, and C4 vertebral bodies; each device measured 4 mm diameter×10 mm length. The left-sided vertebral body devices were implanted using regular surgical drilling (R) while the right-sided devices were implanted using osseodensification drilling (OD). The C2 and C4 vertebra provided the t=0 in vivo time point, while the C3 vertebra provided the t=3 and t=6 week time points, in vivo. Structural competence of hardware was measured using biomechanical testing of pullout strength, while the quality and degree of new bone formation and remodeling was assessed via histomorphometry. Pullout strength demonstrated osseodensification drilling to provide superior anchoring when compared to the control group collapsed over time with statistical significance (p < 0.01). On Wilcoxon rank signed test, C2 and C4 specimens demonstrated significance when comparing device pullout (p=0.031) for both, and C3 pullout tests at 3 and 6 weeks collapsed over time had significance as well (p=0.027). Percent bone-to-implant contact (%BIC) analysis as a function of drilling technique demonstrated an OD group with significantly higher values relative to the R group (p < 0.01). Similarly, percent bone-area-fraction-occupancy (BAFO) analysis presented with significantly higher values for the OD group compared to the R group (p=0.024). As a function of time, between 0 and 3 weeks, a decrease in BAFO was observed, a trend that reversed between 3 and 6 weeks, resulting in a BAFO value roughly equivalent to the t=0 percentage, which was attributed to an initial loss of bone fraction due to remodeling, followed by regaining of bone fraction via production of woven bone. Histomorphological data demonstrated autologous bone chips in the OD group with greater frequency relative to the control, which acted as nucleating surfaces promoting new bone formation around the implants, providing superior stability and greater bone density. This alternative approach to a critical component of hardware implantation encourages assessment of current surgical approaches to hardware implantation.

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“…Combined previous reports 27–30 with the results in Figs 1 and 2, formation process of HTO can be analyzed as follows. During HT process, Ti-O-Ti bonds initially dissolve due to the attack of OH − 27,29 , following the reaction: TiO 2 + OH − → HTiO 3 − . Then, HTiO 3 − reacts with TiO 2 and H 2 O to form HTO nuclei: 3TiO 2 + 2HTiO 3 − + 2H 2 O → H 2 Ti 5 O 11 ·H 2 O + 2OH − .…”

Section: Discussionmentioning

confidence: 93%

Cytocompatibility and antibacterial activity of nanostructured H2Ti5O11·H2O outlayered Zn-doped TiO2 coatings on Ti for percutaneous implants

Zhang

Dai

et al. 2017

Sci Rep

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To improve skin-integration and antibacterial activity of percutaneous implants, the coatings comprising an outer layer of H2Ti5O11·H2O (HTO) nanoarrays and an inner layer of microporous Zn-doped TiO2 were fabricated on Ti by micro-arc oxidation (MAO) followed with hydrothermal treatment (HT). During HT process, a large proportion of Zn2+ migrated out from TiO2 layer. TiO2 reacted with OH− and H2O, resulting in the nucleation of HTO. The nuclei grew to nanoplates, nanorods and nanofibres with HT process prolonged. Simultaneously, the orientation of nanoarrays changed from quasi-vertical to parallel to substrate. Compared to Ti, adhesion and proliferation of fibroblasts were enhanced on as-MAOed TiO2 and HTed coatings. The phenotype, differentiation and extracellular collagen secretion were obviously accelerated on vertical nanorods with proper interspace (e.g. 63 nm). HTed coatings showed enhanced antibacterial activity, which should be ascribed to the nano-topography of HTO.

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Synergistic Effects of Surface Chemistry and Topologic Structure from Modified Microarc Oxidation Coatings on Ti Implants for Improving Osseointegration

Cited by 75 publications

References 56 publications

Combinatorial Surface Roughness Effects on Osteoclastogenesis and Osteogenesis

Combinatorial Surface Roughness Effects on Osteoclastogenesis and Osteogenesis

Osseodensification for enhancement of spinal surgical hardware fixation

Cytocompatibility and antibacterial activity of nanostructured H2Ti5O11·H2O outlayered Zn-doped TiO2 coatings on Ti for percutaneous implants

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