Synergistic effect of Trikatuk, a traditional Thai formulation, on antioxidant and alpha-glucosidase inhibitory activities

Nutmakul, Thanutchaporn; Chewchinda, Savita

doi:10.1016/j.heliyon.2023.e13063

Cited by 8 publications

(8 citation statements)

References 29 publications

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“…A study of the three species of Z. officinale with Cinnamomum burmannii and Caesalpinia sappan showed that the combination of ginger had either higher total phenolic or antioxidant activity than the non-combination (Mahmudati et al, 2022). Study on a combination of herbs, named Trikatuk, in many combinations, resulting in most of the combinations investigated in the present study also exhibiting additive or synergistic effects (Nutmakul & Chewchinda, 2023).…”

Section: Introductionmentioning

confidence: 53%

Combination of polyherbal Phyllanthus reticulatus with Zingiber officinale and Cymbopogon citratus to optimize the antioxidant capacity

Kristiani,

Kasmiyati,

Martono

2024

Pharmaciana

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Currently, the public is interested in polyherbal-based foods and beverages as a source of natural antioxidants. The aim of the study is to evaluate the antioxidant properties and the phenolic and flavonoid compounds of formulations containing Z. officinale, C. citratus, and P. reticulatus (ZCP). Each sample was extracted using the maceration process in an ethanol solvent at room temperature for three 72-hour periods. There were fourteenth formulation of Z. officinale rhizome, C. citratus leaves, and P. reticulatus fruit which used Design of Expert (DoE). The DPPH method was used to determine the power of antioxidants. The flavonoid content of the extract was measured using the colorimetric method and AlCl3 reagent, while phenolics content using Folin-Ciocalteu. The formulations ZCP 1:0:0, 0:0:1, and 1:1:1 showed the antioxidant capacity in a strong categorization, with an IC50 value less than 50 µg/ml, while ZCP 0:1:0 was in a weak categorization (IC50 > 250 µg/mL). Another ZCP formulation was in a medium category. The ZCP 1:1:1 formulation was suggested as the best one for this investigation, which contains three plant samples. This formulation is interesting for further toxicity studies and in vivo testing so that it can be applied as an antioxidant-rich supplement product.

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Section: Introductionmentioning

confidence: 53%

Combination of polyherbal Phyllanthus reticulatus with Zingiber officinale and Cymbopogon citratus to optimize the antioxidant capacity

Kristiani,

Kasmiyati,

Martono

2024

Pharmaciana

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“…Briefly, 20 μl mouthwash was mixed with 50 μl FCR for 3 min. Then, 80 μl 7.5 % w/v sodium carbonate was added and incubated the reaction for 2 h. Absorbance at 765 nm was determined and inferred to the standard curve of gallic acid [ 22 ].…”

Section: Methodsmentioning

confidence: 99%

Anti-oral streptococci and anti-biofilm properties of Etlingera pavieana essential oil and its bioactive compounds proposed for an alternative herbal mouthwash

Wongsariya,

Lapirattanakul,

Chewchinda

et al. 2024

Heliyon

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“…The same case occurs in medicinal plants. Synergistic interactions between medicinal plant mixtures or extracts are an important part of therapeutic efficacy (Ialongo et al, 2023;Komariah et al, 2023;Nutmakul and Chewchinda, 2023;Ranjutha et al, 2023). Therefore, it is necessary to assess the synergy of medicinal plant extracts or endophytic fungal extracts using exacting analytical techniques and to confirm the results in clinical studies.…”

Section: The Combination Effect Of Its Pure Compounds On Antioxidant ...mentioning

confidence: 99%

Combination Effect of Extracts and Pure Compounds of Endophytic Fungi Isolated from Sungkai (Peronema canescens) Leaves on Antioxidant Activity

Elfita,

Oktiansyah,

Mardiyanto

et al. 2024

Sci. Technol. Indones

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Endophytic fungi extracts have various biological and pharmacological activities as natural antioxidants which have the potential to be developed in the pharmaceutical. Drugs made from natural substances frequently work best when they are present in large quantities. This may result in unfavorable side effects from using more of one substance at a time. This limitation can be overcome by using a combination of the extracts/pure compounds that allow synergistic interactions with strong antioxidant properties at fairly low concentrations. The purpose of this research was to determine the combined effect of endophytic fungi extracts and its pure compounds on their antioxidant activity. This research was initiated by rejuvenating eight selected endophytic fungal isolates from Sungkai leaves and morphological characterization was carried out. Each fungus was cultivated in PDB medium for 4 weeks under statistical conditions. Ethyl acetate was used to extract the endophytic fungi’s liquid culture, which was then evaporated. Each endophytic fungal extract (PD1-PD8) and their five pure compounds were tested for antioxidant activity by the DPPH method. Then a combination of two and three extracts was carried out with a ratio of 1:1. The results show that the interaction of the mixture of endophytic fungi extracts and their pure compounds can be classified as synergistic (combined effect of the extracts > individual effects), additive (combined effect of the extracts = individual effect), and nothing is antagonistic (combined effect of the extracts < individual effects). The best combination in this study was PD4+PD5+PD6 (1:1:1) which could be used as a formula for further research into in vivo immunostimulant tests. Another conclusion from this research is that the pure compounds contained in the extracts have lower antioxidant activity than the extracts and do not have a synergistic effect on the combination.

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Synergistic effect of Trikatuk, a traditional Thai formulation, on antioxidant and alpha-glucosidase inhibitory activities

Cited by 8 publications

References 29 publications

Combination of polyherbal Phyllanthus reticulatus with Zingiber officinale and Cymbopogon citratus to optimize the antioxidant capacity

Combination of polyherbal Phyllanthus reticulatus with Zingiber officinale and Cymbopogon citratus to optimize the antioxidant capacity

Anti-oral streptococci and anti-biofilm properties of Etlingera pavieana essential oil and its bioactive compounds proposed for an alternative herbal mouthwash

Combination Effect of Extracts and Pure Compounds of Endophytic Fungi Isolated from Sungkai (Peronema canescens) Leaves on Antioxidant Activity

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