Synergistic antibacterial effects of curcumin modified silver nanoparticles through ROS-mediated pathways

Song, Zhiyong; Wu, Yang; Wang, Huajuan

doi:10.1016/j.msec.2018.12.053

Cited by 123 publications

(83 citation statements)

References 40 publications

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“…Wang et al prepared positively charged bis-quaternary ammonium salt (BQAS) and found that BQAS had a strong contact with bacterial cells and produced temporary high concentration reactive oxygen species (mainly ·O 2 − ), which triggered oxidative stress and membrane damage in bacteria and played a bactericidal role [ 48 ]. Curcumin-modified AgNPs have been shown to have a strong antibacterial effect, mainly due to the increased production of reactive oxygen species (mainly superoxide production) and bacterial death caused by membrane damage [ 47 ].…”

Section: Resultsmentioning

confidence: 99%

“…The absence of fluorescence indicated that the nanomaterial itself does not oxidize DCFH-DA, inferring that MnO 2 nanosheets induce the production of intracellular ROS in bacteria, which might contribute to the antibacterial effect. ROS levels are reported to be related to antibacterial activity due to their destructive effect on bacterial cell membranes [47].…”

Section: Generation Of Rosmentioning

confidence: 99%

“…Zheng et al designed the La@GO nanocomposites, which can achieve the destruction of antibiotic-resistant bacteria due to a unique extracellular multi-target invasion and and membrane damage in bacteria and played a bactericidal role [48]. Curcumin-modified AgNPs have been shown to have a strong antibacterial effect, mainly due to the increased production of reactive oxygen species (mainly superoxide production) and bacterial death caused by membrane damage [47].…”

Section: Perturbation Of Membrane Integrity By Mno2 Nanosheetsmentioning

confidence: 99%

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Antibacterial Activity of Manganese Dioxide Nanosheets by ROS-Mediated Pathways and Destroying Membrane Integrity

Chen

Zhang

et al. 2020

Nanomaterials

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Manganese dioxide (MnO2) nanosheets have shown exciting potential in nanomedicine because of their ultrathin thickness, large surface area, high near-infrared (NIR) absorbance and good biocompatibility. However, the effect of MnO2 nanosheets on bacteria is still unclear. In this study, MnO2 nanosheets were shown for the first time to possess highly efficient antibacterial activity by using Salmonella as a model pathogen. The growth curve and surface plate assay uncovered that 125 μg/mL MnO2 nanosheets could kill 99.2% of Salmonella, which was further verified by fluorescence-based live/dead staining measurement. Mechanism analysis indicated that MnO2 nanosheet treatment could dramatically induce reactive oxygen species production, increase ATPase activity and cause the leakage of electrolytes and protein contents, leading to bacterial death. These results uncover the previously undefined role of MnO2 nanosheets and provide novel strategies for developing antimicrobial agents.

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Section: Resultsmentioning

confidence: 99%

Section: Generation Of Rosmentioning

confidence: 99%

Section: Perturbation Of Membrane Integrity By Mno2 Nanosheetsmentioning

confidence: 99%

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Antibacterial Activity of Manganese Dioxide Nanosheets by ROS-Mediated Pathways and Destroying Membrane Integrity

Chen

Zhang

et al. 2020

Nanomaterials

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“…Productions of intercellular ROS have become the most important indicator towards toxicity related to nanoparticles as they may induce lipid damage, leakage of cellular biomolecules and eventually lead to cell apoptosis [72]. Song et al (2018) have found out that treatment with curcumin and AgNPs may enhance the antibacterial properties towards B. sublitis and E. coli by increasing the formation of ROS which leads to membrane damage and is followed by cell death [73]. The TEM results of the study described that the rupture of the cell membrane in the treated group with curcumin and AgNPs.…”

Section: Antibacterial Properties Of Agnpsmentioning

confidence: 99%

The Potential of Silver Nanoparticles for Antiviral and Antibacterial Applications: A Mechanism of Action

et al. 2020

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Rapid development of nanotechnology has been in high demand, especially for silver nanoparticles (AgNPs) since they have been proven to be useful in various fields such as medicine, textiles, and household appliances. AgNPs are very important because of their unique physicochemical and antimicrobial properties, with a myriad of activities that are applicable in various fields, including wound care management. This review aimed to elucidate the underlying mechanisms of AgNPs that are responsible for their antiviral properties and their antibacterial activity towards the microorganisms. AgNPs can be synthesized through three different methods—physical, chemical, and biological synthesis—as indicated in this review. The applications and limitations of the AgNPs such as their cytotoxicity towards humans and the environment, will be discussed. Based on the literature search obtained, the properties of AgNPs scrutinizing the antibacterial or antiviral effect shown different interaction towards bacteria which dependent on the synthesis processes followed by the morphological structure of AgNPs.

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“…Metal oxide nanoparticles (MO-NPs), such as zinc oxide, gold or silver nanoparticles [93][94][95], are another very promising RONS-producing antibiotherapeutic strategy that could be used in combination with other RONS-generating compounds ( Figure 4A). Despite of the fact that there are numerous studies demonstrating the antibacterial role of metal oxide nanoparticles [93,96], their mechanism of action based on RONS-production is still not fully understood.…”

Section: Rons-producing Anti-infectives Are An Attractive Strategy Tomentioning

confidence: 99%

Oxidative Stress-Generating Antimicrobials, a Novel Strategy to Overcome Antibacterial Resistance

et al. 2020

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Antimicrobial resistance is becoming one of the most important human health issues. Accordingly, the research focused on finding new antibiotherapeutic strategies is again becoming a priority for governments and major funding bodies. The development of treatments based on the generation of oxidative stress with the aim to disrupt the redox defenses of bacterial pathogens is an important strategy that has gained interest in recent years. This approach is allowing the identification of antimicrobials with repurposing potential that could be part of combinatorial chemotherapies designed to treat infections caused by recalcitrant bacterial pathogens. In addition, there have been important advances in the identification of novel plant and bacterial secondary metabolites that may generate oxidative stress as part of their antibacterial mechanism of action. Here, we revised the current status of this emerging field, focusing in particular on novel oxidative stress-generating compounds with the potential to treat infections caused by intracellular bacterial pathogens.

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Synergistic antibacterial effects of curcumin modified silver nanoparticles through ROS-mediated pathways

Cited by 123 publications

References 40 publications

Antibacterial Activity of Manganese Dioxide Nanosheets by ROS-Mediated Pathways and Destroying Membrane Integrity

Antibacterial Activity of Manganese Dioxide Nanosheets by ROS-Mediated Pathways and Destroying Membrane Integrity

The Potential of Silver Nanoparticles for Antiviral and Antibacterial Applications: A Mechanism of Action

Oxidative Stress-Generating Antimicrobials, a Novel Strategy to Overcome Antibacterial Resistance

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