Synergistic and antagonistic interactions of anticholinesterase terpenoids in Salvia lavandulaefolia essential oil

Savelev, Sergey U.; Okello, Edward; Perry, Nicolette S. L.; Wilkins, Richard M.; Perry, E K

doi:10.1016/s0091-3057(03)00125-4

Cited by 300 publications

(216 citation statements)

References 27 publications

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“…Savelev et al (SAVeLeV et al, 2003) also reported borneol, α-pinene, bornyl acetate, linalool, and caryophyllene oxide as main compounds in this species. However, in the present work, these compounds were found only in small concentrations of 1.21%, 0.43%, and traces (Tr), respectively.…”

Section: Chemical Composition Of the Essential Oilssupporting

confidence: 56%

“…The synergism among the major and minor compounds should be taken into account since they increase the effect of the antimicrobial activity of the essential oils (SAVeLeV et al, 2003;DeLAMAre et al, 2007). In contrast, some authors attribute the activity of the essential oils of species of sage to certain chemical compounds, such as 1,8-cineole, camphor, α -and β-thujone, borneol, and p-cymene, among others (JALSeNJAK; PeLJNAJK; KUSTrAK, 1987;JANSSeN;SCHeFFer;BAerHeIM, 1987;rADULeSCU;CHILIMeNT;oPreA, 2004;TePe et al, 2004).…”

Section: Shigella Exneri × S Lavandulifoliamentioning

confidence: 99%

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Chemical characterization and antimicrobial activity of essential oils of salvia L. species

Pierozan¹,

Pauletti²,

Rota³

et al. 2009

Ciênc. Tecnol. Aliment.

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Section: Chemical Composition Of the Essential Oilssupporting

confidence: 56%

Section: Shigella Exneri × S Lavandulifoliamentioning

confidence: 99%

Chemical characterization and antimicrobial activity of essential oils of salvia L. species

Pierozan¹,

Pauletti²,

Rota³

et al. 2009

Ciênc. Tecnol. Aliment.

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“…Most pertinently, both have been shown to inhibit the cholinesterase group of enzymes. Dose-dependent inhibition of butyrylcholinesterase (BuChE) by Salvia officinalis purpurea essential oil (Savelev et al, 2004) and inhibition of acetylcholinesterase (AChE) by both essential oils and extracts (Perry et al, 1996(Perry et al, , 2000Savelev et al, 2003) have been demonstrated in human postmortem brain tissue or bovine erythrocytes. Importantly, CNS availability has been confirmed with the observation that 5 days in vivo oral administration to rats of essential oil led to dose-dependent decreases in AChE activity in selected brain regions .…”

Section: Introductionmentioning

confidence: 99%

Effects of Cholinesterase Inhibiting Sage (Salvia officinalis) on Mood, Anxiety and Performance on a Psychological Stressor Battery

Kennedy

Pace

Haskell

et al. 2005

Neuropsychopharmacol

116

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Salvia officinalis (sage) has previously been shown both to possess in vitro cholinesterase inhibiting properties, and to enhance mnemonic performance and improve mood in healthy young participants. In this double-blind, placebo-controlled, crossover study, 30 healthy participants attended the laboratory on three separate days, 7 days apart, receiving a different treatment in counterbalanced order on each occasion (placebo, 300, 600 mg dried sage leaf). On each day mood was assessed predose and at 1 and 4 h postdose. Each mood assessment comprised completion of Bond-Lader mood scales and the State Trait Anxiety Inventory (STAI) before and after 20 min performance of the Defined Intensity Stress Simulator (DISS) computerized multitasking battery. In a concomitant investigation, an extract of the sage leaf exhibited dose-dependent, in vitro inhibition of acetylcholinesterase and, to a greater extent, butyrylcholinesterase. Both doses of sage led to improved ratings of mood in the absence of the stressor (that is, in pre-DISS mood scores) postdose, with the lower dose reducing anxiety and the higher dose increasing 'alertness', 'calmness' and 'contentedness' on the Bond-Lader mood scales. The reduced anxiety effect following the lower dose was, however, abolished by performing the DISS, with the same dose also being associated with a reduction of alertness during performance. Task performance on the DISS battery was improved for the higher dose at both postdose sessions, but reduced for the lower dose at the later testing session. The results confirm previous observations of the cholinesterase inhibiting properties of S. officinalis, and improved mood and cognitive performance following the administration of single doses to healthy young participants.

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“…This correlation is important as in vitro evaluations of 1,8 cineole have shown that it may possess direct pharmacological properties [49], or act as a suitable marker for the absorption of the Advances in Chemical Engineering and Science highly active compounds rosmarinic acid [50] and ursolic acid [51] that are found in Rosemary essential oil. In terms of the overall pattern of impact on cognition, we contend that there is the potential for a synergistic effect derived from the presence of all three of these compounds in blood serum as previously reported elsewhere [52]. Given their small size and lipid soluble chemical nature passage across the blood brain barrier would be facilitated [53], permitting direct action at the neuronal receptor site, or indirectly at the enzymatic level.…”

Section: Discussionmentioning

confidence: 58%

Any Sense in Classroom Scents? Aroma of Rosemary Essential Oil Significantly Improves Cognition in Young School Children

Moss¹,

Earl²,

Moss³

et al. 2017

ACES

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The inhalation of the aroma of Rosemary essential oil has been shown to enhance cognition in healthy adults. In this independent groups design study we exposed forty schoolchildren aged nine to eleven years to either Rosemary aroma or no aroma in a classroom setting where they completed standardised tests of working memory in fifteen minute procedure. Analysis of the data revealed that performance on the Immediate serial recall, Sentence span, and Counting span tasks were significantly better in the Rosemary aroma condition and possessed medium to large effect sizes. This is the first study to demonstrate such effects in children and suggests that the potential for enhancement is greater than in adults. The findings are discussed in terms of the potential for improving academic attainment through natural interventions and the possible mechanisms behind such effects.

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Synergistic and antagonistic interactions of anticholinesterase terpenoids in Salvia lavandulaefolia essential oil

Cited by 300 publications

References 27 publications

Chemical characterization and antimicrobial activity of essential oils of salvia L. species

Chemical characterization and antimicrobial activity of essential oils of salvia L. species

Effects of Cholinesterase Inhibiting Sage (Salvia officinalis) on Mood, Anxiety and Performance on a Psychological Stressor Battery

Any Sense in Classroom Scents? Aroma of Rosemary Essential Oil Significantly Improves Cognition in Young School Children

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