Synergetic stimulation of nanostructure and chemistry cues on behaviors of fibroblasts and endothelial cells

Remodeling the Senescent Microenvironment for Promoting Osteoporotic Tendon-to-Bone Healing via Synergizing Senolytic Quercetin and Aligned Nanowire-Structured Hydrogels

“…The integration of topographical and biological cues in biomaterials offers a promising avenue for addressing senescence-driven deficiencies in tendon-to-bone healing. 47,48 Earlier studies have highlighted that aligned cryogel fibers can promote cell migration and spatial organization during early bone repair, while biochemical cues, such as QK and KP peptide modifications, regulate cellular functions, enhancing vascularization and osteogenic differentiation. 49 Based on these findings, our previous research demonstrated that scaffolds with aligned architectures could guide the tenogenic differentiation of STDSCs and modulate the inflammatory microenvironment to enhance bone regeneration and tendon repair.…”

Remodeling the Senescent Microenvironment for Promoting Osteoporotic Tendon-to-Bone Healing via Synergizing Senolytic Quercetin and Aligned Nanowire-Structured Hydrogels

“…The integration of topographical and biological cues in biomaterials offers a promising avenue for addressing senescence-driven deficiencies in tendon-to-bone healing. 47,48 Earlier studies have highlighted that aligned cryogel fibers can promote cell migration and spatial organization during early bone repair, while biochemical cues, such as QK and KP peptide modifications, regulate cellular functions, enhancing vascularization and osteogenic differentiation. 49 Based on these findings, our previous research demonstrated that scaffolds with aligned architectures could guide the tenogenic differentiation of STDSCs and modulate the inflammatory microenvironment to enhance bone regeneration and tendon repair.…”

Macroporous Granular Hydrogels Functionalized with Aligned Architecture and Small Extracellular Vesicles Stimulate Osteoporotic Tendon‐To‐Bone Healing

“…[39] Combined structural and biochemical signals provided by biomaterials may synergistically improve cellular communication, differentiation, and tissue regeneration. [40] For instance, our previous study found that aligned electrospun nanofibers and bioactive ions from bioglass jointly stimulated fibroblastendothelial interactions to enhance chronic wound healing. [41] The bioglass ionic products primarily facilitated cell-cell communication through paracrine effects, while the aligned nanofibers synergistically stimulated cell-cell interactions through gap junctional communication.…”

ECM-inspired micro/nanofibers for modulating cell function and tissue generation

“…Previous studies illustrated that topographical cues such as aligned nanogrooved substrate and carbon nanotubes could modulate cell shape and suppress fibroblast proliferation ( 27 ). On the other hand, studies have reported a significant synergistic stimulating effect on cell proliferation and differentiation from the topological and chemistry cues of bioscaffolds ( 35 ). In this study, with the increase of COL-I proportion, an up-regulated cell proliferation could also be found on both anisotropic and random fiber scaffolds, indicating the important role of chemical cues of substrates on supporting the cell adhesion and proliferation, consistent with previous findings ( 16 ).…”

Remodeling the Senescent Microenvironment for Promoting Osteoporotic Tendon-to-Bone Healing via Synergizing Senolytic Quercetin and Aligned Nanowire-Structured Hydrogels

“…The integration of topographical and biological cues in biomaterials offers a promising avenue for addressing senescence-driven deficiencies in tendon-to-bone healing. 47,48 Earlier studies have highlighted that aligned cryogel fibers can promote cell migration and spatial organization during early bone repair, while biochemical cues, such as QK and KP peptide modifications, regulate cellular functions, enhancing vascularization and osteogenic differentiation. 49 Based on these findings, our previous research demonstrated that scaffolds with aligned architectures could guide the tenogenic differentiation of STDSCs and modulate the inflammatory microenvironment to enhance bone regeneration and tendon repair.…”

Macroporous Granular Hydrogels Functionalized with Aligned Architecture and Small Extracellular Vesicles Stimulate Osteoporotic Tendon‐To‐Bone Healing

“…[39] Combined structural and biochemical signals provided by biomaterials may synergistically improve cellular communication, differentiation, and tissue regeneration. [40] For instance, our previous study found that aligned electrospun nanofibers and bioactive ions from bioglass jointly stimulated fibroblastendothelial interactions to enhance chronic wound healing. [41] The bioglass ionic products primarily facilitated cell-cell communication through paracrine effects, while the aligned nanofibers synergistically stimulated cell-cell interactions through gap junctional communication.…”

ECM-inspired micro/nanofibers for modulating cell function and tissue generation

“…Previous studies illustrated that topographical cues such as aligned nanogrooved substrate and carbon nanotubes could modulate cell shape and suppress fibroblast proliferation ( 27 ). On the other hand, studies have reported a significant synergistic stimulating effect on cell proliferation and differentiation from the topological and chemistry cues of bioscaffolds ( 35 ). In this study, with the increase of COL-I proportion, an up-regulated cell proliferation could also be found on both anisotropic and random fiber scaffolds, indicating the important role of chemical cues of substrates on supporting the cell adhesion and proliferation, consistent with previous findings ( 16 ).…”

Remodeling the Senescent Microenvironment for Promoting Osteoporotic Tendon-to-Bone Healing via Synergizing Senolytic Quercetin and Aligned Nanowire-Structured Hydrogels

“…The integration of topographical and biological cues in biomaterials offers a promising avenue for addressing senescence-driven deficiencies in tendon-to-bone healing. 47,48 Earlier studies have highlighted that aligned cryogel fibers can promote cell migration and spatial organization during early bone repair, while biochemical cues, such as QK and KP peptide modifications, regulate cellular functions, enhancing vascularization and osteogenic differentiation. 49 Based on these findings, our previous research demonstrated that scaffolds with aligned architectures could guide the tenogenic differentiation of STDSCs and modulate the inflammatory microenvironment to enhance bone regeneration and tendon repair.…”

Macroporous Granular Hydrogels Functionalized with Aligned Architecture and Small Extracellular Vesicles Stimulate Osteoporotic Tendon‐To‐Bone Healing

“…[39] Combined structural and biochemical signals provided by biomaterials may synergistically improve cellular communication, differentiation, and tissue regeneration. [40] For instance, our previous study found that aligned electrospun nanofibers and bioactive ions from bioglass jointly stimulated fibroblastendothelial interactions to enhance chronic wound healing. [41] The bioglass ionic products primarily facilitated cell-cell communication through paracrine effects, while the aligned nanofibers synergistically stimulated cell-cell interactions through gap junctional communication.…”

ECM-inspired micro/nanofibers for modulating cell function and tissue generation

“…Previous studies illustrated that topographical cues such as aligned nanogrooved substrate and carbon nanotubes could modulate cell shape and suppress fibroblast proliferation ( 27 ). On the other hand, studies have reported a significant synergistic stimulating effect on cell proliferation and differentiation from the topological and chemistry cues of bioscaffolds ( 35 ). In this study, with the increase of COL-I proportion, an up-regulated cell proliferation could also be found on both anisotropic and random fiber scaffolds, indicating the important role of chemical cues of substrates on supporting the cell adhesion and proliferation, consistent with previous findings ( 16 ).…”