Synergetic Effects of Prenatal and Postnatal High Sucrose Intake on Glucose Tolerance and Hepatic Insulin Resistance in Rat Offspring

Zhang, Pengjie; Zhu, Di; Zhang, Yueming; Chen, Xiong-Hui; Zhang, Wenna; Shi, Ruixiu; Tao, Jianying; Han, Bing; Xu, Zhice

doi:10.1002/mnfr.201700771

Cited by 11 publications

(20 citation statements)

References 31 publications

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“…Although several terms for mice were included in the database search, only rat studies were identified. Eleven of the included papers used Sprague-Dawley rats, 31,[38][39][40][41][42][43][44][45][46][47] three used Wistar rats 30,48,49 and one did not report strain type. 29 Sucrose was administered at either 10% w/v [29][30][31]48,49 or 20% w/v 29,[38][39][40][41][42][43][44][45][46][47] and maternal exposure ranged from 16 to 126 days, including periods during pre-conception, gestation and lactation.…”

Section: Study Characteristics and Designmentioning

confidence: 99%

“…Eleven of the included papers used Sprague-Dawley rats, 31,[38][39][40][41][42][43][44][45][46][47] three used Wistar rats 30,48,49 and one did not report strain type. 29 Sucrose was administered at either 10% w/v [29][30][31]48,49 or 20% w/v 29,[38][39][40][41][42][43][44][45][46][47] and maternal exposure ranged from 16 to 126 days, including periods during pre-conception, gestation and lactation. The majority 29,30,[32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47] employed a compulsory drinking paradigm with sucrose solution being the only source of drinkin...…”

Section: Study Characteristics and Designmentioning

confidence: 99%

“…29 Sucrose was administered at either 10% w/v [29][30][31]48,49 or 20% w/v 29,[38][39][40][41][42][43][44][45][46][47] and maternal exposure ranged from 16 to 126 days, including periods during pre-conception, gestation and lactation. The majority 29,30,[32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47] employed a compulsory drinking paradigm with sucrose solution being the only source of drinking fluid. A voluntary consumption model was used in two papers, with sucrose offered in addition to drinking water.…”

Section: Study Characteristics and Designmentioning

confidence: 99%

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Metabolic and behavioural effects in offspring exposed to maternal sucrose consumption: a systematic review and meta-analysis of data from rodent models

Morahan

Leenaars

Boakes

et al. 2020

J Dev Orig Health Dis

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Consumption of sugar-sweetened beverages (SSBs) during pregnancy has been associated with childhood obesity. Research in which rodent dams have been given high-fat/high-sugar diets has consistently found metabolic alterations in their offspring. However, what remains unclear is the potential impact on the developing fetus of giving sugar in isolation at concentrations similar to SSBs to the mothers. Therefore, we conducted a systematic review and meta-analysis (Protocol No: 127115 on Prospero) to identify potential relationships between maternal sucrose consumption and metabolic outcomes in offspring of rodent (rat or mouse) models. We analysed studies that provided rodent mothers dams with access to sucrose solutions (8–20% w/v) prior to conception, during pregnancy and/or lactation and that reported offspring outcomes of body weight (BW), body composition and glycaemic control. Following a systematic search of four databases (PubMed, EMBASE, Web of Science and Scopus) performed on 15 January 2019, maternal and offspring data from 15 papers were identified for inclusion. Only rat studies were identified. Meta-analyses were performed on standardised mean differences for maternal and offspring BW and fasting glucose levels, with subgroup analyses of strain, sucrose concentration, exposure period and sex of offspring. A bias towards the inclusion of only data from male offspring was identified and this limited interpretation of potential sexually dimorphic outcomes. Maternal sucrose exposure was associated with an increased risk of obesity and poor glucose disposal in adult and aged offspring.

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Section: Study Characteristics and Designmentioning

confidence: 99%

Section: Study Characteristics and Designmentioning

confidence: 99%

Section: Study Characteristics and Designmentioning

confidence: 99%

See 1 more Smart Citation

Metabolic and behavioural effects in offspring exposed to maternal sucrose consumption: a systematic review and meta-analysis of data from rodent models

Morahan

Leenaars

Boakes

et al. 2020

J Dev Orig Health Dis

View full text Add to dashboard Cite

show abstract

“…When the pregnant dam consumes a larger quantity of sugar during pregnancy, metabolic changes in the pups may persist during post-natal life. This affects pancreas development and glucose tolerance in male offspring [38]. In addition, when offspring have been exposed to high sucrose during gestation, exposure to high sucrose later in adulthood worsens glucose tolerance.…”

Section: Influence Of Dietary Intakes During Gestation and Or Lactmentioning

confidence: 99%

“…In addition, when offspring have been exposed to high sucrose during gestation, exposure to high sucrose later in adulthood worsens glucose tolerance. This could be explained by a default of hepatic insulin signaling [38]. Sugar consumption by rat dams during gestation and lactation induces an increase in body weight, blood glucose and plasma insulin levels in mothers and pups in a dose-dependent manner [39].…”

Section: Influence Of Dietary Intakes During Gestation and Or Lactmentioning

confidence: 99%

Effects of Nutrient Intake during Pregnancy and Lactation on the Endocrine Pancreas of the Offspring

Moullé

Parnet

2019

Nutrients

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The pancreas has an essential role in the regulation of glucose homeostasis by secreting insulin, the only hormone with a blood glucose lowering effect in mammals. Several circulating molecules are able to positively or negatively influence insulin secretion. Among them, nutrients such as fatty acids or amino acids can directly act on specific receptors present on pancreatic beta cells. Dietary intake, especially excessive nutrient intake, is known to modify energy balance in adults, resulting in pancreatic dysfunction. However, gestation and lactation are critical periods for fetal development and pup growth and specific dietary nutrients are required for optimal growth. Feeding alterations during these periods will impact offspring development and increase the risk of developing metabolic disorders in adulthood, leading to metabolic programming. This review will focus on the influence of nutrient intake during gestation and lactation periods on pancreas development and function in offspring, highlighting the molecular mechanism of imprinting on this organ.

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Prenatal High‐Sucrose Diet Induced Vascular Dysfunction of Renal Interlobar Arteries in the Offspring via PPARγ‐RXRg‐ROS/Akt Signaling

Feng,

Liu,

Wang

et al. 2024

Molecular Nutrition Food Res

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ScopePrenatal nutrition imbalance correlates with developmental origin of cardiovascular diseases; however whether maternal high‐sucrose diet (HS) during pregnancy causes vascular damage in renal interlobar arteries (RIA) from offspring still keeps unclear.Methods and resultsPregnant rats are fed with normal drinking water or 20% high‐sucrose solution during the whole gestational period. Swollen mitochondria and distributed myofilaments are observed in vascular smooth muscle cells of RIA exposed to prenatal HS. Maternal HS increases phenylephrine (PE)‐induced vasoconstriction in the RIA from adult offspring. NG‐Nitro‐l‐arginine (L‐Name) causes obvious vascular tension in response to PE in offspring from control group, not in HS. RNA‐Seq of RIA is performed to reveal that the gene retinoid X receptor g (RXRg) is significantly decreased in the HS group, which could affect vascular function via interacting with PPARγ pathway. By preincubation of RIA with apocynin (NADPH inhibitor) or capivasertib (Akt inhibitor), the results indicate that ROS and Akt are the vital important factors to affect the vascular function of RIA exposure to prenatal HS.ConclusionMaternal HS during the pregnancy increases PE‐mediated vasoconstriction of RIA from adult offspring, which is mainly related to the enhanced Akt and ROS regulated by the weakened PPARγ‐RXRg.

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Synergetic Effects of Prenatal and Postnatal High Sucrose Intake on Glucose Tolerance and Hepatic Insulin Resistance in Rat Offspring

Cited by 11 publications

References 31 publications

Metabolic and behavioural effects in offspring exposed to maternal sucrose consumption: a systematic review and meta-analysis of data from rodent models

Metabolic and behavioural effects in offspring exposed to maternal sucrose consumption: a systematic review and meta-analysis of data from rodent models

Effects of Nutrient Intake during Pregnancy and Lactation on the Endocrine Pancreas of the Offspring

Prenatal High‐Sucrose Diet Induced Vascular Dysfunction of Renal Interlobar Arteries in the Offspring via PPARγ‐RXRg‐ROS/Akt Signaling

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