Syndecan-2, negatively regulated by miR-20b-5p, contributes to 5-fluorouracil resistance of colorectal cancer cells via the JNK/ERK signaling pathway

Hua, Ruheng; Zhang, Yan; Yan, Xiaohui; Tang, Dong; Li, Xiaolong; Ni, Qingfeng; Wang, Daorong; Jun, Zhu

doi:10.1093/abbs/gmab124

Cited by 4 publications

(2 citation statements)

References 26 publications

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“…MiR-20b has an essential role in chemotherapy resistance. It has been demonstrated that the activation of Syndecan-2, a transmembrane receptor, is positively correlated with chemotherapy resistance [ 75 ]. Mechanistically, miR-20b diminishes the resistance of cancer cells to chemotherapy by targeting Syndecan-2 [ 75 ].…”

Section: Approaches To Determine the Targets Of Mir-20bmentioning

confidence: 99%

“…It has been demonstrated that the activation of Syndecan-2, a transmembrane receptor, is positively correlated with chemotherapy resistance [ 75 ]. Mechanistically, miR-20b diminishes the resistance of cancer cells to chemotherapy by targeting Syndecan-2 [ 75 ]. Its capability to regulate the sensitivity of cancer cells to chemotherapy drugs through hypoxia signaling pathways has profoundly been displayed.…”

Section: Approaches To Determine the Targets Of Mir-20bmentioning

confidence: 99%

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The dual role of microRNA (miR)-20b in cancers: Friend or foe?

et al. 2023

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MicroRNAs, as non-coding transcripts, modulate gene expression through RNA silencing under normal physiological conditions. Their aberrant expression has strongly associated with tumorigenesis and cancer development. MiR-20b is one of the crucial miRNAs that regulate essential biological processes such as cell proliferation, apoptosis, autophagy, and migration. Deregulated levels of miR-20b contribute to the early- and advanced stages of cancer. On the other hand, investigations emphasize the tumor suppressor ability of miR-20b. High-throughput strategies are developed to identify miR-20b potential targets, providing the proper insight into its molecular mechanism of action. Moreover, accumulated results suggest that miR-20b exerts its effects through diverse signaling pathways, including PI3K/AKT/mTOR and ERK axes. Restoration of the altered expression levels of miR-20b induces cell apoptosis and reduces invasion and migration. Further, miR-20b can be used as a biomarker in cancer. The current comprehensive review could lead to a better understanding of the miR-20b in either tumorigenesis or tumor regression that may open new avenues for cancer treatment.

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Section: Approaches To Determine the Targets Of Mir-20bmentioning

confidence: 99%

Section: Approaches To Determine the Targets Of Mir-20bmentioning

confidence: 99%

The dual role of microRNA (miR)-20b in cancers: Friend or foe?

et al. 2023

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Correlation of syndecan gene amplification with metastatic potential and clinical outcomes in carcinomas

Kim,

Yang,

Cho

et al. 2024

American Journal of Physiology-Cell Physiology

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Cell surface receptors play crucial roles in cellular responses to extracellular ligands, helping to modulate the functions of a cell based on information coming from outside the cell. Syndecan refers to a family of cell adhesion receptors that regulate both extracellular and cytosolic events. Alteration of syndecan expression disrupts regulatory mechanisms in a cell type-specific fashion, often leading to serious diseases, notably cancer. Given the multifaceted functions and distinct tissue distributions of syndecan, it will be important to unravel the gene-level intricacies of syndecan expression and thereby further understand its involvement in various carcinogenic processes. Although accumulating evidence indicates that the protein expression patterns of syndecan family members are significantly altered in cancer cells, the underlying gene-level mechanisms remain largely unknown. This review endeavors to explore syndecan gene expression levels across different cancer types by scrutinizing extensive cancer genome datasets utilizing tools such as cBioPortal. Our analysis unveils that somatic mutations in SDC genes are rare occurrences, whereas copy number alterations are frequently observed across diverse cancers, particularly in SDC2 and SDC4. Notably, amplifications of SDC2 and SDC4 correlate with heightened metastatic potential and dismal prognosis. This underscores the recurrent nature of SDC2 and SDC4 amplifications during carcinogenesis and sheds light on their role in promoting cancer activity through augmented protein expression. The identification of these amplifications not only enriches our understanding of carcinogenic mechanisms but also hints at the potential therapeutic avenue of targeting SDC2 and SDC4 to curb cancer cell proliferation and metastasis.

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The emerging role of miR-20b in human cancer and other disorders: Pathophysiology and therapeutic implications

et al. 2022

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miR-20b is a microRNA with diverse and somehow contradictory roles in the pathogenesis of human disorders, especially cancers. It has been known to be a tumor suppressor in colon cancer, renal cell carcinoma, prostate cancer, osteosarcoma and papillary thyroid cancer. In lung cancer and breast cancers, both tumor suppressor and oncogenic effects have been identified for this miRNA. Finally, in T cell leukemia, hepatocellular carcinoma, esophageal squamous cell carcinoma and cervical and gastric cancers, miR-20b is regarded as an oncogenic miRNA. In several types of cancer, dysregulation of miR-20b has been recognized as a predictive marker for patients’ survival. Dysregulation of miR-20b has also been recognized in Alzheimer’s disease, diabetic retinopathy, myocardial ischemia/infarction, chronic hepatitis B and multiple sclerosis. In the current review, we have summarized the miR-20b targets and related cellular processes. We have also provided a review of participation of this miRNA in different human disorders.

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Syndecan-2, negatively regulated by miR-20b-5p, contributes to 5-fluorouracil resistance of colorectal cancer cells via the JNK/ERK signaling pathway

Cited by 4 publications

References 26 publications

The dual role of microRNA (miR)-20b in cancers: Friend or foe?

The dual role of microRNA (miR)-20b in cancers: Friend or foe?

Correlation of syndecan gene amplification with metastatic potential and clinical outcomes in carcinomas

The emerging role of miR-20b in human cancer and other disorders: Pathophysiology and therapeutic implications

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