Synchronously detected secondary signet ring cell urinary bladder malignancy from the stomach masquerading as genitourinary tuberculosis

Abstract

SUMMARYSecondary bladder neoplasms are very rare and represent 1% of all malignant bladder tumours. Among secondary bladder tumours, metastasis from the stomach accounts for about 4% of cases. These secondary tumours are generally detected during follow-up of patients already treated for gastric cancer. We report a case of metastatic adenocarcinoma of the urinary bladder from an occult primary poorly differentiated signet ring cell type gastric carcinoma masquerading clinically as genitourinary tuberculosis. Our case illustrates the importance of obtaining a bladder biopsy in suspected chronic inflammatory conditions such as urinary tract tuberculosis before starting medical management to avoid the serious consequences of missing a bladder malignancy. BACKGROUND

Metastatic Signet-Ring-Cell Carcinoma of Bladder From Breast Invasive Lobular Carcinoma Found By CT: A Case Report And Literature Review

“…Primary SRCC of the bladder is extremely uncommon, with an estimated prevalence of 0.24% of all primary bladder cancer (11,12). Metastatic SRCC of the bladder is even rarer (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24). We searched PubMed, MEDLINE, Embase, and Google Scholar using the key words such as "gastric or stomach"; "signet-ring-cell carcinoma"; "breast or mammary"; "bladder" and "metastasis."…”

“…Almost all the patients with gross hematuria showed a protuberant mass in imaging. While in patients with lower urinary tract symptoms (LUTS) as the rst symptom, the imaging ndings are often diffuse wall thickening (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)36). In our case, the pelvic CT had the manifestation of diffuse thickening of the bladder wall for 9 months before the diagnosis of SRCC.…”

Bladder metastasis of gastric signet-ring cell carcinoma

“…These regimens have been found to be superior to the earlier gold standard of fluorouracil, doxorubicin and mitomycin. 5 In our case, we used 4 cycles of 5-fluorouracil and calcium folinate and 6 cycles of capecitabine and oxaliplatin in adjuvant setting. Later in the recurrence three cycles of irinotecan and capecitabine and then three cycles of irinotecan, capecitabine and oxaliplatin was given to the patient.…”

Metastasis of Gastric Signet-Ring Cell Carcinoma to the Urinary Bladder: A Case Report and Review of the Literature

“…Including our case, there are 16 cases in the English literature reporting bladder metastasis secondary to gastric cancer [ 8 – 19 ] ( Table 1 ). The majority of the cases are above 50 years of age.…”

“…Histologically, bladder adenocarcinomas represent less than 2% of primary bladder tumors and 54% of secondary tumors [ 17 ]. Primary SRC bladder adenocarcinomas are much more rare and account for 0.24% of all bladder malignancies [ 18 , 19 ]. SRC histology is more common in gastrointestinal system tumors and particularly in gastric cancer and is seen in 3.4% to 39% of the patients [ 20 ].…”