Synchronous primary cancers in the head and neck region and upper aero digestive tract: Role of triple endoscopy

Krishnatreya, Manigreeva; Rahman, Tashnin; Kataki, AC; Lahkar, K

doi:10.4103/0019-509x.175560

Cited by 9 publications

(12 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is a large discrepancy between the prevalence of esophageal-SPTs in patients with HNSCC found with Lugol chromoendoscopy screening (15%, 95% CI: [11][12][13][14][15][16][17][18][19] and the prevalence of retrospective non-screening studies (1%-6%). 6,7,[49][50][51][52][53] This was also noted by Wang, Lee, et al 31 This discrepancy could indicate that without an active screening program, esophageal-SPTs are underdiagnosed in patients with HNSCC. 7 Multiple studies state that the occurrence of esophageal-SPTs negatively influences patient survival, especially in patients with advanced esophageal-SPTs.…”

Section: Discussionmentioning

confidence: 90%

“…There is a large discrepancy between the prevalence of esophageal‐SPTs in patients with HNSCC found with Lugol chromoendoscopy screening (15%, 95% CI: 11‐19) and the prevalence of retrospective non‐screening studies (1%‐6%) . This was also noted by Wang, Lee, et al This discrepancy could indicate that without an active screening program, esophageal‐SPTs are underdiagnosed in patients with HNSCC .…”

Section: Discussionmentioning

confidence: 95%

See 1 more Smart Citation

Early detection of esophageal second primary tumors using Lugol chromoendoscopy in patients with head and neck cancer: A systematic review and meta‐analysis

et al. 2018

View full text Add to dashboard Cite

Background Early detection of esophageal secondary primary tumors (SPTs) in head and neck squamous cell carcinoma (HNSCC) patients could increase patient survival. The purpose of this study was to determine the diagnostic yield of esophageal SPTs using Lugol chromoendoscopy. Methods A systematic review of all available databases was performed to find all Lugol chromoendoscopy screening studies. Results Fifteen studies with a total of 3386 patients were included. The average yield of esophageal‐SPTs in patients with HNSCC was 15%. The prevalence was the highest for patients with an index hypopharyngeal (28%) or oropharyngeal (14%) tumor. The esophageal‐SPTs were classified as high‐grade dysplasia in 49% of the cases and as invasive carcinoma's in 51%. Conclusion Our results show that 15% of the patients with HNSCC that underwent Lugol chromoendoscopy were diagnosed with an esophageal‐SPT. Based on these results there is enough evidence to perform Lugol chromoendoscopy, especially in an Asian patient population.

show abstract

Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 95%

Early detection of esophageal second primary tumors using Lugol chromoendoscopy in patients with head and neck cancer: A systematic review and meta‐analysis

et al. 2018

View full text Add to dashboard Cite

show abstract

“…After the first 5 years, the patient continues follow‐up once per year with a clinical visit, regardless of subsite cancer and stage at diagnosis or treatments received. Several studies evaluated the role of triple endoscopy in this setting, especially in pre‐treated work‐up to diagnosticate the synchronous SPT (Krishnatreya et al., 2015; Priante et al., 2014; Sharma et al., 2018). However, most reports only describe the frequency of diagnoses and not the benefit on survival of these patients (Priante et al., 2011).…”

Section: Discussionmentioning

confidence: 99%

Second primary tumors in head and neck cancer patients: The importance of a “tailored” surveillance

et al. 2020

View full text Add to dashboard Cite

Objective Head and neck cancer survivors have increased risk of developing second primary tumors compared to overall population. Because second primary represents a major cause of morbidity and mortality in this population, early detection is fundamental. Materials and Methods In this 10‐year single‐institution study, we investigated the following: incidence, clinical‐pathological risk factors, and survival of patients with second primary tumor. We included all patients with diagnosis of squamous cell carcinoma of the head and neck seen at the Modena University Hospital from 2008 to 2018. Results Among 1,177 patients included, 222 (18.9%) developed second primary tumor; its survival probability at 5 years was 40.6%. Alcohol consumption (p = .0055) and index cancer in oropharynx (p = .0029), supraglottic larynx (p = .0000), glottic larynx (p = .0222) were associated with higher risk of second primary. The most common second primary sites were head and neck district and lung (70, 31.5%, and 67, 30.2%, respectively). Head and neck district were more common in oral cavity (18, 43%) and oropharynx index cancer (20, 31%); lung second primary in hypopharynx (4, 40%), supraglottic larynx (17, 43%), and glottic larynx index cancer (23, 35%). Conclusion Head and neck cancer survivors developing a second primary tumor have dismal prognosis. Tailored surveillance is recommended.

show abstract

“…Triple endoscopy refers to the inspection of the pharynx, larynx, esophagus, trachea and bronchi to determine both candidacy of surgical resection and presence of SPTs using endoscopes in the operating room under general anesthesia 4 . In HNSCC, SPTs are identified in just 1–2% of triple endoscopy cases and are more likely to be detected in older patients and those with tobacco or alcohol use 5,6 . More recently, other methods for detecting SPTs, such as radiographic imaging (e.g., positron emission tomography/computed tomography or PET/CT) have become more standard components of oncologic workup.…”

Section: Introductionmentioning

confidence: 99%

“…4 In HNSCC, SPTs are identified in just 1-2% of triple endoscopy cases and are more likely to be detected in older patients and those with tobacco or alcohol use. 5,6 More recently, other methods for detecting SPTs, such as radiographic imaging (e.g., positron emission tomography/computed tomography or PET/CT) have become more standard components of oncologic workup. In contrast, PET/CT is an imaging modality that utilizes [ 18 F]fluorodeoxyglucose (FDG) to detect areas of hypermetabolic activity consistent with malignancy.…”

Section: Introductionmentioning

confidence: 99%

PET/CTversus triple endoscopy in initial workup ofHPV+ oropharyngeal squamous cell carcinoma

2022

View full text Add to dashboard Cite

Background Synchronous primary tumors (SPTs) are detected via triple endoscopy or positron emission tomography/computed tomography (PET/CT). Patients with human papillomavirus‐associated oropharyngeal squamous cell carcinoma (HPV+ OPSCC) lack risk factors for SPTs. Methods We performed a single institution retrospective review of the efficacy of triple endoscopy and PET/CT in HPV+ OPSCC patients. Results Sixty‐five HPV+ OPSCC patients underwent triple endoscopy and PET/CT. Patients were white (n = 48, 72.7%), male (n = 53, 81.5%), mean 58.7 ± 8.1 years old. SPT was detected in 1 (1.5%) patient via PET/CT. No SPTs were detected on triple endoscopy. PET/CT had 100% and 95.3% sensitivity and specificity, respectively. PET/CT positive predictive value (PPV) and negative predictive value (NPV) were 25.0% and 100%, respectively. Triple endoscopy specificity and NPV was 90.2% and 93.2%, respectively. Conclusions PET/CT is superior to triple endoscopy in ruling out SPTs. With negative PET/CT, only direct laryngoscopy with biopsy may be necessary.

show abstract

Synchronous primary cancers in the head and neck region and upper aero digestive tract: Role of triple endoscopy

Cited by 9 publications

References 1 publication

Early detection of esophageal second primary tumors using Lugol chromoendoscopy in patients with head and neck cancer: A systematic review and meta‐analysis

Early detection of esophageal second primary tumors using Lugol chromoendoscopy in patients with head and neck cancer: A systematic review and meta‐analysis

Second primary tumors in head and neck cancer patients: The importance of a “tailored” surveillance

PET/CTversus triple endoscopy in initial workup ofHPV+ oropharyngeal squamous cell carcinoma

Contact Info

Product

Resources

About