Synchronous detection of ebolavirus conserved RNA sequences and ebolavirus-encoded miRNA-like fragment based on a zwitterionic copper (II) metal–organic framework

Qiu, Guang; Weng, Zihua; Hu, Peipei; Duan, Wenjun; Xie, Bingbing; Sun, Bin; Tang, Xiao‐Yan; Chen, Jinxiang

doi:10.1016/j.talanta.2017.12.045

Cited by 53 publications

(30 citation statements)

References 46 publications

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“… Virus Target viral nucleic acid sequences Probe DNA strands (P-DNA) Refs. HIV-1 ss-DNA 5′-GCTAGAGATTTTCCACACTGACT-3′ 5′-FAM-CATGTGTCCAGCTGATTGCC-3′ Pan et al (2018) HIV-1 ds-DNA 5′-CGAGTTAAGAAGAAAAAAGATTGAGC-3′ /5′-GCTCAATCTTTTTTCTTCTTAACTCG-3′ 5′-FAM-TTCTTCTTTTTTCT-3′ ( Li et al, 2016 ; Yang et al, 2015 ) SUDV RNA 5′-GAUGAGGACAAACUUUUUAA-3′ 5′-FAM-TTAAAAAGTTTGTCCTCATC-3′ ( Li et al, 2016 ; Yang et al, 2015 ) Ebola virus Ebola virus conserved sequence of RNA (T 1 ) 5′-GGCAAUCAGUUGGACACAUG-3′ The complementary sequence for T 1 as probe DNA-1 (P-DNA-1) 5′-CATGTGTCCAACTGATTGCC-FAM-3′ Qiu et al (2018) Ebola virus-encoded miRNA-like fragment (T 2 ) 5′-UGCUUCAUUAGCACUUUGGGGC-3′ The complementary sequence for T 2 as probe DNA-2 (P-DNA-2) 5′-GCCCCAAAGTGCTAATGAAGCA-ROX-3′ Zika virus (ZIKV) 5′-ACUUGGGUGGAUAGGUAGUCCAUGU-3′ 5′-TAMRA-ACATGGACTACCTATCCACCCAAGT-3′ Li et al (2019b) Dengue virus (DENV) 5′-UGGUGCUGUUGAAUCAACAGGUUCU-3′ 5′-FAM-AGAACCTGTTGATTCAACAGCACCA-3′ Xie et al (2018) Hepatitis B virus (HBV) 5′-TTGTCCTGGCTATCGCTGGATGTGTCTGC-3′ 5′-TATATAGCAGACACATCCAGCGATAGCCAGGACAATATATA-FAM-3′ Ye et al (2014) …”

Section: Viral Nucleic Acid Detection Based On Mofmentioning

confidence: 99%

“…Multi-virus detection is significant in clinical prediagnosis for some certain indistinguishable diseases including DENV and ZIKV which are related to different types of nucleic acids. At present, the Cu-based MOFs, such as {[Cu(Cmdcp) (phen) (H 2 O)] 2 ·9H 2 O} n ( Qiu et al, 2018 ), [Cu(Dcbcp) (bpe)] n ( Xie et al, 2018 ), [Cu(Dcbb) (bipy) (OH)] n ( Xie et al, 2019 ), are the mostly studied materials in simultaneous detection owing to their unique structures and efficient fluorescence quenching ability of Cu 2+ .…”

Section: Viral Nucleic Acid Detection Based On Mofmentioning

confidence: 99%

“…The 3D framework was equipped with conjugated phen ligands, positively charged Cu(II) ions, and pyridinium centers, which were ideal for facilitating interactions with the negatively charged aromatic nucleotide bases of P-DNA to form the sensing system of DNA@MOF. Qiu et al, (2018) developed a water-soluble and stable zwitterionic copper (II) MOF, {[Cu(Cmdcp) (phen) (H 2 O)] 2 ·9H 2 O} n , for synchronous detection of ebolavirus-encoded miRNA-like fragment and ebolavirus conserved RNA sequences with detection limits of 206 pM and 60 pM, respectively ( Fig. 8 A).…”

Section: Viral Nucleic Acid Detection Based On Mofmentioning

confidence: 99%

“…8 (A) Synchronous detection of target Ebola virus conserved RNA sequences (T 1 ) and Ebola virus-encoded miRNA-like fragment sequences (T 2 ) based on a fluorescent biosensor formed from MOF 1 and probe DNAs (P-DNA-1 and P-DNA-2). Reproduced with permission from ( Qiu et al, 2018 ). Copyright 2018, Elsevier.…”

Section: Viral Nucleic Acid Detection Based On Mofmentioning

confidence: 99%

“…And the uncoordinated N atoms and carboxylates were also hydrogen-bonding acceptors for promoting interactions with the P-DNA. Compared to similar Cu-based MOF, the Q E values of [Cu(Dcbb) (bipy) (OH)] n (average: 96% for ROX, 88% for FAM and 80% for Cy5) ( Xie et al 2019 ) was slightly higher than that Cu-based detection platform, such as [Cu(Dcbcp) (bpe)] n for Zika and Dengue virus RNA sequences (92% for ROX and 82% for FAM) ( Xie et al 2018 ), N, N -bis(2-hydroxy-ethyl)dithiooxamidato copper(II) (H 2 dtoaCu) for HBV and HIV RNA sequences (91% for ROX, 85% for FAM) ( Ye et al 2014 ), and {[Cu(Cmdcp) (phen) (H 2 O)] 2 ·9H 2 O} n for the Ebola virus-encoded miRNA-like fragment and ebolavirus conserved RNA sequences (95% for ROX and 80% for FAM) ( Qiu et al 2018 ), which was related to its unique structural flexibility, and conjugate structure of benzene, pyridinium and bipy rings, as well as varied hydrogen bond acceptor of uncoordinated N atoms and carboxylates.…”

Section: Viral Nucleic Acid Detection Based On Mofmentioning

confidence: 99%

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Metal-organic frameworks for virus detection

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Virus severely endangers human life and health, and the detection of viruses is essential for the prevention and treatment of associated diseases. Metal-organic framework (MOF), a novel hybrid porous material which is bridged by the metal clusters and organic linkers, has become a promising biosensor platform for virus detection due to its outstanding properties including high surface area, adjustable pore size, easy modification, etc. However, the MOF-based sensing platforms for virus detection are rarely summarized. This review systematically divided the detection platforms into nucleic acid and immunological (antigen and antibody) detection, and the underlying sensing mechanisms were interpreted. The nucleic acid sensing was discussed based on the properties of MOF (such as metal ion, functional group, geometry structure, size, porosity, stability, etc.), revealing the relationship between the sensing performance and properties of MOF. Moreover, antibodies sensing based on the fluorescence detection and antigens sensing based on molecular imprinting or electrochemical immunoassay were highlighted. Furthermore, the remaining challenges and future development of MOF for virus detection were further discussed and proposed. This review will provide valuable references for the construction of sophisticated sensing platform for the detection of viruses, especially the 2019 coronavirus.

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Section: Viral Nucleic Acid Detection Based On Mofmentioning

confidence: 99%

Section: Viral Nucleic Acid Detection Based On Mofmentioning

confidence: 99%

Section: Viral Nucleic Acid Detection Based On Mofmentioning

confidence: 99%

Section: Viral Nucleic Acid Detection Based On Mofmentioning

confidence: 99%

Section: Viral Nucleic Acid Detection Based On Mofmentioning

confidence: 99%

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Metal-organic frameworks for virus detection

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Polyphenol‐Containing Nanoparticles: Synthesis, Properties, and Therapeutic Delivery

et al. 2021

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Polyphenols, the phenolic hydroxyl group-containing organic molecules, are widely found in natural plants and have shown beneficial effects on human health. Recently, polyphenol-containing nanoparticles have attracted extensive research attention due to their antioxidation property, anticancer activity, and universal adherent affinity, and thus have shown great promise in the preparation, stabilization, and modification of multifunctional nanoassemblies for bioimaging, therapeutic delivery, and other biomedical applications. Additionally, the metal−polyphenol networks, formed by the coordination interactions between polyphenols and metal ions, have been used to prepare an important class of polyphenol-containing nanoparticles for surface modification, bioimaging, drug delivery, and disease treatments. By focusing on the interactions between polyphenols and different materials (e.g., metal ions, inorganic materials, polymers, proteins, and nucleic acids), a comprehensive review on the synthesis and properties of the polyphenol-containing nanoparticles is provided. Moreover, the remarkable versatility of polyphenol-containing nanoparticles in different biomedical applications, including biodetection, multimodal bioimaging, protein and gene delivery, bone repair, antibiosis, and cancer theranostics is also demonstrated. Finally, the challenges faced by future research regarding the polyphenol-containing nanoparticles are discussed.

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Zinc and Cadmium Complexes of Pyridinemethanol Carboxylates: Metal Carboxylate Zwitterions and Metal–Organic Frameworks

et al. 2020

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The heterofunctional lactone furo [3,4-b]pyridin-5(7H)-one (L 1 ) undergoes a coordination-induced ring-opening reaction with Zn(NO 3 ) 2 · 6H 2 O to yield the zwitterionic [Zn(L 1 ') 2 (H 2 O) 2 ] (1, L 1 ' = 2-(hydroxymethyl)nicotinate) with an uncoordinated carboxylate. The same reaction with Cd(NO 3 ) 2 · 4H 2 O provides a twodimensional (2D) network of [Cd(L 1 ') 2 ] n (3) with the carboxylates coordinated to cadmium(II) propagating the assembly. The corresponding reactions of Zn(NO 3 ) 2 · 6H 2 O and Cd(NO 3 ) 2 · 4H 2 O with 2-(hydroxymethyl)isonicotinic acid (HL 2 ) generated zwitter-ionic [Zn(L 2 ) 2 (H 2 O) 2 ] (2) and a 2D network [Cd(L 2 ) 2 ] n ·nDMF (4, DMF = N,N'-dimethylformamide), respectively. Complexes 1-4 are weakly emissive, giving ligand-centered emissions at 409 nm (1), 412/436 nm (2), 404 nm (3), and 412/436 nm (4) in CHCl 3 solutions upon excitation at 330 nm. This work points to the potential of using 'hidden' functionalities widely found in small organic molecules and natural products for the construction of coordination complexes with new functionality and potential applications. Cd(NO 3 ) 2 ·4H 2 O (15.5 mg, 0.05 mmol) and L 1 (13.5 mg, 0.1 mmol) were added to a Pyrex glass tube (10 cm in length and 0.5 cm in diameter) followed by DMF/H 2 O (1 mL/2 mL). The tube was sealed and heated in an oven at 120°C for three days and gradually cooled to ambient temperature at a rate of 5°C min À 1 . The colourless crystals formed were filtered, washed with DMF and dried under vacuum. Yield: (8.1 mg, 39 % based on Cd). Anal. Calcd. (%) for C 14 H 12 CdN 2 O 6 : C 40. 36, H 2.90, N 6.72; found: C 40.78, H 2.91, N 6.93. Cd(NO 3 ) 2 · 4H 2 O (31 mg, 0.1 mmol) and ethyl 2-(hydroxymethyl) isonicotinate (the precursor of HL 2 , 36 mg, 0.2 mmol) were ChemPlusChem Full Papers in DMF/H 2 O (4 mL/4 mL) and heated at 125°C for 72 h in a DURAN glass bottle. The light-yellow crystals formed were filtered and washed with DMF. Yield: (25.0 mg, 51 % based on Cd). Anal.

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Synchronous detection of ebolavirus conserved RNA sequences and ebolavirus-encoded miRNA-like fragment based on a zwitterionic copper (II) metal–organic framework

Cited by 53 publications

References 46 publications

Metal-organic frameworks for virus detection

Metal-organic frameworks for virus detection

Polyphenol‐Containing Nanoparticles: Synthesis, Properties, and Therapeutic Delivery

Zinc and Cadmium Complexes of Pyridinemethanol Carboxylates: Metal Carboxylate Zwitterions and Metal–Organic Frameworks

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