Symptoms and Their Interpretation in Patients Self-Treating Abdominal Cramping and Pain with a Spasmolytic (Butylscopolamine Bromide)—A Pharmacy-Based Survey

Müller-Lissner, S; Schäfer, Eckhard; Kondla, Anke

doi:10.4236/pp.2011.22010

Cited by 6 publications

(16 citation statements)

References 17 publications

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“…With respect to the effectiveness of treatment, HBB users tended to be more satisfied with their treatment for relief of their symptoms and fast onset of action than women in other treatment groups. These data are consistent with the results of 3 methodologically different studies showing that oral HBB has a fast onset of action and that pain relief can be expected as early as 15 minutes after intake of 20 mg HBB [8,10,11,16]. In a recent survey, rapid onset of action was reported by the participants as most important, followed by "highly effective" and "well tolerated" [2].…”

Section: Discussionsupporting

confidence: 88%

“…Abdominal pain and cramping were highly prevalent, affecting 31 % of respondents from the UK, 27 % of those from Italy, and 12 % of those from Germany [1]. Consistent with other findings, abdominal pain and cramping were more common in women (12 -55 %) than in men (7 -38 %) [1,8].…”

Section: Discussionsupporting

confidence: 85%

“…Standard treatment of IBS generally involves a symptom-directed approach with medication aimed at alleviating the pain and related symptoms [2]. The majority of those affected by abdominal pain and cramping use medication on demand to relieve them from pain episodes; these drugs are predominantly available over the counter (OTC) and include antispasmodics, herbal extracts, and analgesics [1,2,8]. Antispasmodics are the most frequently used class of treatment, though this varies considerably from country to country [2].…”

Section: Introductionmentioning

confidence: 99%

“…Hyoscine butylbromide (HBB, Buscopan ® ) is an antispasmodic drug indicated for the treatment of mild to moderate spasm of the GI tract and for the treatment of spasmodic abdominal pain in IBS [9]. In Germany, HBB has been registered as a prescription drug for the treatment of IBS symptoms since 1951, becoming available OTC in 2001 [8]. HBB, being widely available OTC in many countries, is effective and well tolerated for the treatment of abdominal pain associated with cramping and is now used to treat a broad spectrum of abdominal complaints [10,11].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Abdominal pain, cramping or discomfort impairs quality of life in women: An internet-based observational pilot study focussing on impact of treatment

Enck¹,

Koehler

Weigmann

et al. 2017

Z Gastroenterol

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Abdominal pain, cramping, and discomfort (APCD) are experienced by up to 30 % of adults in Europe. To assess the impact of APCD on quality of life (QoL) and to investigate the effectiveness, tolerability, and impact on QoL of hyoscine butylbromide (HBB, Buscopan) compared with STW 5 (Iberogast) or analgesics in women with APCD. An internet-based observational pilot study was conducted in Germany in women who had predominantly used HBB, STW 5, or analgesics (n = 240 per treatment) to treat APCD. This online survey included questions on QoL, effectiveness, and tolerability. A total of 720 completed questionnaires was evaluated. APCD had a major impact on QoL, with 96 % of women reporting that daily activities were disrupted at least sometimes, and 44 % at least often. Other aspects of QoL, such as quality of work, eating habits, and social activities, were also affected in most women. After taking their medication of choice, 91 % of women in the HBB group reported they could "very often" or "often" continue with their daily activities, compared with 84 % and 85 % in the STW 5 and analgesic groups, respectively (p < 0.05 for both comparisons). HBB was perceived to be the "best solution" to overcome APCD symptoms "very often" or "often" by more women (86 %) than STW 5 (75 %) and analgesics (74 %) (p < 0.05 for both comparisons). Women with APCD have impaired QoL. All treatments were considered effective by the majority of participants. Compared with STW 5 or analgesics, HBB was reported to facilitate return to daily activities more frequently.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Abdominal pain, cramping or discomfort impairs quality of life in women: An internet-based observational pilot study focussing on impact of treatment

Enck¹,

Koehler

Weigmann

et al. 2017

Z Gastroenterol

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“…Thus, pharmacies are promising touchpoints for contacting and running surveys with headache patients to gather information on their complaints and treatment responses to analgesics. Pharmacy-based patient surveys have provided valuable information in the context of TTH and migraine ( 5 , 6 ) and other indications that include abdominal spasms and pain ( 7 ) or cough and cold ( 8 , 9 ). To better understand the complaints of headache patients with and without accompanying NSP and their treatment responses, a pharmacy-based survey was performed on patients suffering from headaches that were treated with an OTC analgesic, the fixed-dose combination of 400 mg ibuprofen, and 100 mg caffeine (IbuCaff).…”

Section: Introductionmentioning

confidence: 99%

Impact of the Neck and/or Shoulder Pain on Self-reported Headache Treatment Responses – Results From a Pharmacy-Based Patient Survey

et al. 2022

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Neck and/or shoulder pain (NSP) frequently occurs together with headache. Therefore, we explored how patients with and without concomitant NSP differ in their baseline characteristics and in perceived treatment responses to an analgesic. An anonymous survey was performed among 895 patients with headache (735 self-reported tension-type headache [TTH]) who used an analgesic fixed-dose combination containing 400 mg ibuprofen and 100 mg caffeine as a non-prescription treatment. NSP was abundant among patients in our survey (60%) and was associated with >1 additional day of headache per month. Patients with NSP reported predominantly sedentary work more frequently than those without (40 vs. 29%); they also reported physical tension/poor posture as a perceived trigger factor more frequently (70 vs. 16%). The reported pain reduction was comparable in those with and without concomitant NSP regardless of whether assessed as mean pain rating (from about 6 to 1.5 on a 10-point rating scale), patients experiencing a ≥50% in pain reduction (89.6 vs. 88.8%) or becoming pain-free within 2 h (57 vs. 64%). However, recurrence of pain and use of another dose within the same day were more frequent with than without NSP. We conclude that concomitant NSP is frequent in patients with headache but does not substantially alter responses to a non-prescription medication.

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Self-Medication for the Treatment of Abdominal Cramps and Pain – a Real-Life Comparison of Three Frequently Used Preparations

Storr¹,

Weigmann²,

Landes³

et al. 2022

Preprint

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Functional gastro-intestinal disorders (FGID) including irritable bowel syndrome (IBS) are frequently handled by self-management with over the counter (OTC) products such as hyoscine butylbromide (HBB), alone or in combination with paracetamol, and natural products such as peppermint oil. To obtain real-world information, we have performed an anonymous pharmacy-based patient survey among 1686 users of HBB, HBB + paracetamol and peppermint oil. Based on the distinct but overlapping indications for the three OTC products, multiple logistic regression was applied to compare them in users reporting gastrointestinal cramps and pain, bloating, flatulence, or IBS as cardinal symptom. All three treatments reduced symptoms and associated impairments of work/daily chores, leisure activities, and sleep by approximately 50%. Based on the four cardinal symptoms and the four dependent continuous variables of interest (change of intensity of symptoms and of the three impairment domains) a total of 16 logistic regression models were applied. HBB, HBB + paracetamol, and peppermint oil had similar reported overall effectiveness in those models. Gender, age, baseline symptom severity and impairment in one of three domains had small and inconsistent effects on perceived treatment success. We provide evidence that HBB, HBB + paracetamol, and peppermint oil have comparable effectiveness in their approved indications under real-world conditions in an OTC setting.

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Symptoms and Their Interpretation in Patients Self-Treating Abdominal Cramping and Pain with a Spasmolytic (Butylscopolamine Bromide)—A Pharmacy-Based Survey

Abstract: ABSTRACT

Cited by 6 publications

References 17 publications

Abdominal pain, cramping or discomfort impairs quality of life in women: An internet-based observational pilot study focussing on impact of treatment

Abdominal pain, cramping or discomfort impairs quality of life in women: An internet-based observational pilot study focussing on impact of treatment

Impact of the Neck and/or Shoulder Pain on Self-reported Headache Treatment Responses – Results From a Pharmacy-Based Patient Survey

Self-Medication for the Treatment of Abdominal Cramps and Pain – a Real-Life Comparison of Three Frequently Used Preparations

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