Symptomatic and Asymptomatic Interphalangeal Osteoarthritis: An Ultrasonographic Study

Usón, Jacqueline; Fernández-Espartero, Cruz; Villaverde, Virginia; Condés, Emilia; Godo, Javier; Martínez-Blasco, Maria Jesus; Miguelez, Roberto

doi:10.1016/j.reumae.2014.01.008

Cited by 14 publications

(17 citation statements)

References 15 publications

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“…The level of high sensitivity C reactive protein and presence of synovitis are greater in patients with symptomatic HOA than without symptomatic HOA, so OA-related pain could result in part from low-grade inflammation. 22 23 As well, systemic inflammation promotes atherosclerosis and coronary heart disease development. 24 However, this observational cross-sectional study could not allow for determining a causal association between HOA and coronary heart disease and we did not have assessments of blood inflammatory biomarkers.…”

Section: Discussionmentioning

confidence: 99%

Coronary heart disease is associated with a worse clinical outcome of hand osteoarthritis: a cross-sectional and longitudinal study

et al. 2017

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ObjectiveTo determine whether cardiometabolic factors are associated with hand osteoarthritis (HOA) symptoms, radiographic severity and progression in a post hoc analysis of the phase III Strontium ranelate Efficacy in Knee OsteoarthrItis triAl (SEKOIA) trial, designed to determine the effect of strontium ranelate on knee osteoarthritis (OA).MethodsAmong the 1683 patients randomised in the SEKOIA study, 869 with radiographic HOA at baseline (rHOA≥2 joints with Kellgren-Lawrence grade ≥2) were included in a cross-sectional analysis. For longitudinal study, we included only the 307 patients with rHOA at baseline from the placebo group. We evaluated whether baseline symptomatic HOA, radiographic severity and clinical and rHOA progression were associated with coronary heart disease and/or metabolic diseases (obesity, diabetes and hypertension, dyslipidaemia) by multivariate regression analysis.ResultsAt baseline, 869 patients (72% women) were included in the cross-sectional analysis; 26% were symptomatic. On multivariate analysis, symptomatic HOA was associated with coronary heart disease (OR 3.59, 95% CI (1.78 to 7.26)) but not metabolic diseases. After a mean follow-up of 2.6 years, for the 307 participants in the placebo group, on multivariate analysis, worse clinical HOA outcome was associated with coronary heart disease (OR 2.91, 95% CI (1.02 to 8.26)). The slow radiographic progression did not allow for revealing any associated factors.ConclusionsSymptomatic HOA and worse HOA clinical course are associated with coronary heart disease. These results strengthen the systemic component of HOA and the association between OA pain and cardiac events.Trial registration numberISRCTN41323372.

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Section: Discussionmentioning

confidence: 99%

Coronary heart disease is associated with a worse clinical outcome of hand osteoarthritis: a cross-sectional and longitudinal study

et al. 2017

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“…However, understanding how inflammatory features in individual hand joints change over time is important to determine if ultrasound is a valid measure of assessing response to treatment. In a longitudinal study of patients with hand OA, inflammatory features that included synovial thickening, effusion or a power Doppler ultrasonography signal were consistently present in most patients over a 3 month period; however, in individual joints, the inflammatory features changed over time, with persistent inflammatory features found in only 19% of the hand joints 104 . Further investigation in other study populations and over different time periods is recommended before ultrasound is used as the primary outcome measure in assessing treatment response in individuals hand joints.…”

Section: [H1] Imagingmentioning

confidence: 95%

“…Radiography still has a place in the research setting; however, which scoring methods to use is still debated and might depend on the objective of the study and the population studied (for example, patients with erosive versus patients with non-erosive forms of hand OA) 74,75 . Although radiography might have a low sensitivity in detecting features in early disease, the ability of this technique to detect hand OA progression over five years is similar to that of 1.0 Tesla MRI, although these imaging modalities do not always detect progression in the same joints 28 .…”

Section: [H1] Imagingmentioning

confidence: 99%

Hand osteoarthritis: clinical phenotypes, molecular mechanisms and disease management

et al. 2018

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Osteoarthritis (OA) is a highly prevalent condition and the hand is the most commonly affected site. Patients with hand OA frequently report symptoms of pain, functional limitations, and frustration in undertaking everyday activities. The condition presents clinically with changes to the bone, ligaments, cartilage and synovial tissue, which can be observed using radiography, ultrasonography or MRI. Hand OA is a heterogeneous disorder and is considered to be multifactorial in aetiology. This review provides an overview of the epidemiology, presentation and burden of hand OA, including an update on hand OA imaging (including the development of novel techniques), disease mechanisms and management. In particular, areas for which new evidence has substantially changed the way we understand, consider and treat hand OA are highlighted. For example, genetic studies, clinical trials and careful prospective imaging studies from the past 5 years are beginning to provide insights into the pathogenesis of hand OA that might uncover new therapeutic targets in disease.

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“…Musculoskeletal ultrasound (US) is booming in clinical practice for the diagnosis and evaluation of inflammatory lesions from inflammatory disorders, and it has been proven to be effective in the evaluation of bone erosions in musculoskeletal disease osteoarthritis (OA) (7), gout (8), and in psoriatic arthritis (PsA) (9). In RA, many studies have shown that US can detect more erosions than RX at the joint level, especially at an early stage of the disease, with higher sensitivity and specificity than RX when a CT scan is taken as the gold standard imaging method (10).…”

Section: Introductionmentioning

confidence: 99%

Ultrasonographic criteria for the diagnosis of erosive rheumatoid arthritis using osteoarthritic patients as controls compared to validated radiographic criteria

et al. 2019

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HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

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Symptomatic and Asymptomatic Interphalangeal Osteoarthritis: An Ultrasonographic Study

Cited by 14 publications

References 15 publications

Coronary heart disease is associated with a worse clinical outcome of hand osteoarthritis: a cross-sectional and longitudinal study

Coronary heart disease is associated with a worse clinical outcome of hand osteoarthritis: a cross-sectional and longitudinal study

Hand osteoarthritis: clinical phenotypes, molecular mechanisms and disease management

Ultrasonographic criteria for the diagnosis of erosive rheumatoid arthritis using osteoarthritic patients as controls compared to validated radiographic criteria

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