Symplastic glomus tumor: Report of a challenging lesion with literature review

Falleti, Jessica; Vita, Giulia; Cecio, Rossella De; Schönauer, Fabrizio; Insabato, Luigi; Natella, Valentina; Mascolo, Massimo

doi:10.1016/j.prp.2012.04.001

Cited by 11 publications

(17 citation statements)

References 8 publications

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“…Long term follow-up and more cases are needed to further confirm the indolent behavior of this tumor. The histologic appearance and clinical follow-up data in our study of SPN with prominent MNGTCs bear analogy to the degenerative, pleomorphic atypia seen in pleomorphic pancreatic neuroendocrine tumors 16 , symplastic leiomyomas 17 , symplastic glomus tumor 18 , symplastic hemangioma 19 , and bizarre giant cells of mammary fibroadenomas 20 . The presence of atypical cells in these tumors has also been shown to have no significant effect on the prognosis, but the demographic trend appeared to be similar to their conventional counterparts.…”

Section: Discussionsupporting

confidence: 56%

Solid pseudopapillary neoplasm of the pancreas with prominent atypical multinucleated giant tumour cells

Othman

Rashid

et al. 2012

Histopathology

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Aims Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low-grade malignant neoplasm. SPN with prominent atypical multinucleated giant tumor cells (MNGTCs) has not been reported. Methods and results We identified four cases of SPN with prominent atypical MNGTCs in a cohort of 62 cases of SPN (6.5%). The MNGTCs contained multiple enlarged, hyperchromatic, irregular nuclei with ample eosinophilic cytoplasm, typically present in the solid area of the tumor. The MNGTCs had a typical immunohistochemical profile of the conventional SPN and were positive for vimentin, β-catenin, CD10, and progesterone receptor, but were negative for pan-cytokeratin chromogranin, synaptophysin, trypsin, Ki-67 and CD68 in all four cases. Patients of SPN with prominent MNGTCs were older than those with conventional SPN (p=0.01), tumors were incidentally discovered by imaging studies for an unrelated disease in all four cases, and with a female to male ratio of 1:1. The proliferation index (Ki-67) was <1% in all four cases. None of the three patients, whose follow up information was available, developed recurrence during follow-up of 2.7, 3.8 and 5.0 years. Conclusions The presence of MNGTCs in SPN most likely represents degenerative change of the tumor cells and does not seem to affect the prognosis.

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Section: Discussionsupporting

confidence: 56%

Solid pseudopapillary neoplasm of the pancreas with prominent atypical multinucleated giant tumour cells

Othman

Rashid

et al. 2012

Histopathology

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“…to avoid the rupture of the capsule that contained it, the implantation of glomus cells and tumor recurrence 24 , in agreement with treatment data in the literature 25 . is reported by all patients.…”

Section: Discussionsupporting

confidence: 85%

Glomangioma da artéria digital do polegar: relato de um caso

Guillaumon

Bosnardo²,

Meirelles

2012

J. vasc. bras.

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Os autores relatam um caso de tumor glômico em ramo da artéria radial que irriga o polegar direito, com história clínica de 4 meses. O doente referia o aparecimento de tumoração de aproximadamente 2,0 centímetros na região interdigital, entre o primeiro e o segundo quirodactilos da mão direita, sobre o músculo flexor curto do polegar, extremamente dolorosa e com dor em progressão. Os exames com aparelho de Doppler bidirecional e o eco-color-Doppler apresentaram, como diagnóstico presuntivo, malformação arteriovenosa, pelo turbilhonamento do fluxo e ausência de estenoses. A tumoração foi retirada por cirurgia aberta e encaminhada para exame histopatológico, com diagnóstico de glomangioma. Este relato descreve uma doença arterial pouco frequente, que causa extremo desconforto ao seu portador, mas que é solucionada pela exerese cirúrgica, sem sequelas.

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“…Tumor resection provides immediate symptom relief and complete pain resolution (13,14,19,20). In this case, we chose an open surgery because total tumor removal was important to avoid the rupture of the capsule that contained it, the implantation of glomus cells and tumor recurrence (21), in agreement with treatment data in the literature (22).…”

Section: Operative Technique and Resultsmentioning

confidence: 57%

Glomus tumor of the thumb: case report

Al-Sadek¹,

Niklev²,

Al-Sadek³

et al. 2017

TJS

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We report on a case of glomus tumor in the right thumb. The tumor had a 2-year clinical history. The patient reported the development of a 3-5mm tumor in the distal phalangeunder the nail of the right thumb. The patient also complained of severe and progressive pain. Tests using bidirectional Doppler and echo-color-Doppler revealed a presumptive diagnosis of arteriovenous malformation based on the turbulence of the flow and absence of stenosis. The tumor was removed by open surgery and sent for histopathological examination, which showed a diagnosis of glomangioma. The present report describes a rare disease causing extreme discomfort to the patient, which may be treated with surgical resection without sequelae.

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Symplastic glomus tumor: Report of a challenging lesion with literature review

Cited by 11 publications

References 8 publications

Solid pseudopapillary neoplasm of the pancreas with prominent atypical multinucleated giant tumour cells

Solid pseudopapillary neoplasm of the pancreas with prominent atypical multinucleated giant tumour cells

Glomangioma da artéria digital do polegar: relato de um caso

Glomus tumor of the thumb: case report

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