Cell Reports volume 4, issue 2, P287-301 2013 DOI: 10.1016/j.celrep.2013.06.019 View full text
Philip Borden, Jessica Houtz, Steven D. Leach, Rejji Kuruvilla

Abstract: Summary Sympathetic neurons depend on target-derived neurotrophic cues to control their survival and growth. However, whether sympathetic innervation contributes reciprocally to the development of target tissues is less clear. Here, we report that sympathetic innervation is necessary for the formation of the pancreatic islets of Langerhans and for their functional maturation. Genetic or pharmacological ablation of sympathetic innervation during development resulted in altered islet architecture, reduced insul…

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