Symmetric dumbbell ganglioneuromas of bilateral C2 and C3 roots with intradural extension associated with von Recklinghausen's disease: case report

Kyoshima, Kazuhiko; Sakai, Keiichi; Kanaji, Miki; Oikawa, Susumu; Kobayashi, Sumio; Sato, Atsushi; Nakayama, Jun

doi:10.1016/s0090-3019(03)00393-8

Cited by 41 publications

(49 citation statements)

References 19 publications

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“…Derived from the embryonic neural crest, ganglioneuromas arise from sympathoblasts and mainly occur in the sympathetic ganglion and adrenal medulla, common particularly in the posterior mediastinum and retroperitoneal region (11). The explanation for the uncommon location of ganglioneuroma is likely a result of the mechanism of neural crest cell migration in the embryonic period (4).…”

Section: Discussionmentioning

confidence: 99%

Conus medullaris ganglioneuroma with syringomyelia radiologically mimicking ependymoma: A case report

Wang

Dai

2015

Oncology Letters

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Abstract. Ganglioneuromas are rare, benign, well-differentiated tumors of the conus medullaris. Approximately 20 cases of spinal cord ganglioneuroma, and only 1 case of mixed chemodectoma-ganglioneuroma of the conus medullaris have been previously reported. The present study presents the case of a 38-year-old man with a histopathological diagnosis of conus medullaris ganglioneuroma. The patient presented with hypoesthesia in the lower limbs, muscle atrophy of the right lower limb and dysuria. Magnetic resonance imaging analysis led to a diagnosis of ependymoma. Histopathological analysis of the excised mass revealed typical, well-differentiated ganglion cells, consistent with a ganglioneuroma. The mass was associated with a neighboring syringomyelia. At an 18 month follow-up the patient had recovered, although some remaining difficulty in walking and urinating remained. The aim of the present report was to raise awareness that when ganglioneuromas present in unusual locations, analogous radiological findings may mislead investigators to consider more common pathologies and thus result in misdiagnosis. The present case demonstrates the importance of considering the potential differential diagnoses for neural tissue neoplasms.

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Section: Discussionmentioning

confidence: 99%

Conus medullaris ganglioneuroma with syringomyelia radiologically mimicking ependymoma: A case report

Wang

Dai

2015

Oncology Letters

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“…En ocasiones pueden secretar polipéptidos intestinalmente vasoactivos, induciendo entonces un síndrome caracterizado por diarrea, hipopotasemia y aclorhidria 28 , o testosterona, lo que conlleva virilizaciones 7 . Se han descrito ubicaciones en cualquier zona del organismo: supratentoriales 3 , cerebelosas 15 , raquídeas 4,8,10,12,13,24 , mediastínicas 27 , retroperitoneales 22 , intestinales 11 o cutáneas 6 . Cuando su localización es cercana a la medula espinal es frecuente la compresión de la misma o la tracción radicular, pudiendo causar dolor, pér-dida de fuerza o trastornos sensoriales en dependencia del nivel mielo-radicular afecto.…”

Section: Discussionunclassified

Ganglioneuroma coincidente con una extrusión discal lumbar

Martínez-Quiñones¹,

Consolini²,

Aso-Escario³

et al. 2011

Neurocirugía

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ResumenIntroducción. Los ganglioneuromas o gangliomas son tumores de los ganglios simpáticos que contienen células de la cresta neural, pudiendo aparecer en cualquier parte del organismo. Son generalmente benignos, más frecuente entre los 10 y los 40 años, pueden secretar hormonas y, en ocasiones, asociarse a trastornos genéticos, como la neurofibromatosis tipo I.Objetivo. Revisar la literatura científica relacionada con el tema y presentar un caso tratado en nuestro servicio.Discusión. La sintomatología de estas lesiones depende de su ubicación y de las sustancias vasoactivas que puedan secretar. A pesar de que son tumores benignos en su mayoría, en ocasiones pueden metastatizar. Las pruebas de imagen y de laboratorio son inespecíficas, por lo que el diagnóstico definitivo es anatomopatológico. En los casos sintomáticos el tratamiento de elección es la resección quirúrgica.Conclusión. La asociación de un ganglioneuroma y de una hernia discal lumbar es algo excepcional. El tratamiento requiere su resección quirúrgica.PALABRAS CLAVE. Ganglioneuroma. Ganglioma. Hernia discal. Ganglioneuroma coinciding with a lumbar disk herniation SummaryIntroduction. Ganglioneuromas or gangliomas are tumours of the sympathetic ganglia that contain cells of the neural crest, so they can appear in all body localizations. They are generally benign, more frequent between 10 and 40 years, may secrete hormones and, sometimes, Neurofibromatosis type I and other genetic disorders can be associated.

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“…16) The tumors of MEN occur in the adrenal medulla, pancreas, and pituitary together with ganglioneuromas in the mediastinal and retroperitoneal regions. 5,18) The diagnosis of these tumors is usually based on the clinical presentation and neuroimaging findings. 2) Histological examination revealed a neoplastic lesion consisting of spindle-shaped cells arranged in fascicles.…”

Section: Discussionmentioning

confidence: 99%

Intradural Extramedullary Ganglioneuroma Associated With Multiple Hamartoma Syndrome -Case Report-

Tei

Morimoto

Miyamoto

et al. 2007

Neurol. Med. Chir.(Tokyo)

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A 51-year-old woman presented with a rare completely intradural and extramedullary spinal ganglioneuroma associated with multiple hamartoma syndrome and manifesting as complaints of neck pain and dizziness persisting for 8 months. Magnetic resonance imaging of the spinal cord revealed an intradural extramedullary lesion at the C1 level. She underwent right suboccipital craniectomy and C1-2 hemilaminectomy to remove the tumor. Histological examination confirmed ganglioneuroma. She also suffered from multiple facial trichilemmomas, thyroid goiter, multiple polyposis of the gastrointestinal tract, and pulmonary hamartoma indicating multiple hamartoma syndrome. These benign neoplasms were treated conservatively.

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Symmetric dumbbell ganglioneuromas of bilateral C2 and C3 roots with intradural extension associated with von Recklinghausen's disease: case report

Cited by 41 publications

References 19 publications

Conus medullaris ganglioneuroma with syringomyelia radiologically mimicking ependymoma: A case report

Conus medullaris ganglioneuroma with syringomyelia radiologically mimicking ependymoma: A case report

Ganglioneuroma coincidente con una extrusión discal lumbar

Intradural Extramedullary Ganglioneuroma Associated With Multiple Hamartoma Syndrome -Case Report-

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