Switching to testicular sperm after a previous ICSI failure with ejaculated sperm significantly improves blastocyst quality without increasing aneuploidy risk

Hervás, Irene; Juliá, María Gil; Rivera‐Egea, Rocío; Navarro-Gomezlechon, Ana; Mossetti, Laura; Garrido, Nicolás

doi:10.1007/s10815-022-02595-w

Cited by 7 publications

(2 citation statements)

References 66 publications

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“…In this subset, the blastocyst euploid rate per metaphase II oocyte was comparable between ejaculated and testicular sperm‐ICSI (18.7% vs. 18.2%, respectively). The findings of this study were corroborated by Hervas et al 122 . in a study evaluating 375 embryos from 54 ICSI cycles of patients with failed ICSI.…”

Section: Testicular Sperm Injection In Non‐azoospermia and Consequenc...supporting

confidence: 88%

Surgically retrieved spermatozoa for ICSI cycles in non‐azoospermic males with high sperm DNA fragmentation in semen

2023

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Intracytoplasmic sperm injection (ICSI) using surgically retrieved spermatozoa outside the classic context of azoospermia has been increasingly used to overcome infertility. The primary indications include high levels of sperm DNA damage in ejaculated spermatozoa and severe oligozoospermia or cryptozoospermia, particularly in couples with ICSI failure for no apparent reason. Current evidence suggests that surgically retrieved spermatozoa for ICSI in the above context improves outcomes, mainly concerning pregnancy and miscarriage rates. The reasons are not fully understood but may be related to the lower levels of DNA damage in spermatozoa retrieved from the testis compared with ejaculated counterparts. These findings are consistent with the notion that excessive sperm DNA damage can be a limiting factor responsible for the failure to conceive. Using testicular in preference of low‐quality ejaculated spermatozoa bypasses post‐testicular sperm DNA damage caused primarily by oxidative stress, thus increasing the likelihood of oocyte fertilization by genomically intact spermatozoa. Despite the overall favorable results, data remain limited, and mainly concern males with confirmed sperm DNA damage in the ejaculate. Additionally, information regarding the health of ICSI offspring resulting from the use of surgically retrieved spermatoa of non‐azoospermic males is still lacking. Efforts should be made to improve the male partner's reproductive health for safer ICSI utilization. A comprehensive andrological evaluation aiming to identify and treat the underlying male infertility factor contributing to sperm DNA damage is essential for achieving this goal.

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Section: Testicular Sperm Injection In Non‐azoospermia and Consequenc...supporting

confidence: 88%

Surgically retrieved spermatozoa for ICSI cycles in non‐azoospermic males with high sperm DNA fragmentation in semen

2023

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“…Contrary to their findings, the results of our study indicated that the live birth rates of ejaculated sperm and Testicular sperm after ICSI-ET were similar. Moreover, a study conducted by Rene H et al (23) examined 27 couples who initially attempted ICSI with ejaculated sperm but did not achieve a successful pregnancy. Subsequently, they switched to using testicular sperm, and the study revealed that this shift significantly improved blastocyst quality without increasing the risk of aneuploidy.…”

Section: Discussionmentioning

confidence: 99%

Comparing the clinical and singleton neonatal outcomes in male infertility patients with Oligoasthenospermia, OA, or NOA following fresh ICSI-ET using different sources of sperm

Xu,

Yang,

Chen

et al. 2023

Front. Endocrinol.

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ObjectiveTo investigate clinical and singleton newborn outcomes in fresh cycles of embryo transfer after intracytoplasmic sperm injection (ICSI-ET) with diverse sperm sources (ejaculate, epididymis, and testis) in patients with Oligoasthenospermia, obstructive azoospermia (OA) or non-obstructive azoospermia (NOA).MethodsPatients who received fresh ICSI-ET for the first time at the First Affiliated Hospital of Zhengzhou University Reproductive Medicine Center between June 2011 and June 2021 were selected for this 10-year retrospective cohort analysis. After propensity score matching, only 1630 cycles were included in the investigation of ICS-ET clinical and singleton newborn outcomes in patients with Oligoasthenospermia, OA, and NOA using sperm from diverse sperm sources.Result(s)After propensity score matching, our data revealed a negligible difference in baseline and cycle parameters among groups. In patients with Oligoasthenospermia and OA, different sperm sources do not appear to influence clinical pregnancy rates and live birth rates, nor do they influence newborn outcomes, such as newborn weight, premature birth rate, and neonatal sex ratio in singleton births, except for OA patients who use epididymal sperm having higher low birth weight (LBW) rates in singleton pregnancies than those who use testicular sperm. In addition, clinical pregnancy rates, live birth rates, singleton gestation birth weights, premature birth rates, and neonatal sex ratios were similar between patients with Oligoasthenospermia, OA, and NOA using testicular sperm.Conclusion(s)Regardless of the type of male infertility (Oligoasthenospermia, OA, NOA) or sperm sources (ejaculate, epididymis, testis), a successful ICSI-ET procedure can result in similar clinical and neonatal outcomes, such as clinical pregnancy rate, live birth rate, abortion rate, neonatal birth weight and sex ratio of singleton pregnancies.

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Identifying predictors of Day 5 blastocyst utilization rate using an artificial neural network

Serdarogullari,

Raad,

Yarkiner

et al. 2023

Reproductive BioMedicine Online

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Switching to testicular sperm after a previous ICSI failure with ejaculated sperm significantly improves blastocyst quality without increasing aneuploidy risk

Cited by 7 publications

References 66 publications

Surgically retrieved spermatozoa for ICSI cycles in non‐azoospermic males with high sperm DNA fragmentation in semen

Surgically retrieved spermatozoa for ICSI cycles in non‐azoospermic males with high sperm DNA fragmentation in semen

Comparing the clinical and singleton neonatal outcomes in male infertility patients with Oligoasthenospermia, OA, or NOA following fresh ICSI-ET using different sources of sperm

Identifying predictors of Day 5 blastocyst utilization rate using an artificial neural network

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