Swine composite tissue allotransplant model for preclinical hand transplant studies

Lymph Node Inclusion in a Modified Osteomyocutaneous Allograft for Vascularized Composite Allotransplantation: Establishment and Feasibility Assessment in a Pig Model

“…Although the main idea behind the various modifications of the described orthotopic forelimb VCA model 16 , 17 , 30 was to test the flap’s function at an endpoint, the only functional outcome that could be assessed was joint stability by manual manipulation of the joint. However, innervation and sensation could also be theoretically tested.…”

Lymph Node Inclusion in a Modified Osteomyocutaneous Allograft for Vascularized Composite Allotransplantation: Establishment and Feasibility Assessment in a Pig Model

“…Although the main idea behind the various modifications of the described orthotopic forelimb VCA model 16 , 17 , 30 was to test the flap’s function at an endpoint, the only functional outcome that could be assessed was joint stability by manual manipulation of the joint. However, innervation and sensation could also be theoretically tested.…”

A new porcine vascularized tibial bone allotransplantation model. Anatomy and surgical technique

“…Porcine blood type and SLA haplotypes are known, and permit rigorous evaluation of transplant immunology. Whole limb transplantation and other composite tissues have been studied in swine (Kuo et al, ; Ren et al, ; Ustuner et al, ). Lee et al () demonstrated that various VCA tissue components vary in their effect on cellular and humoral immune response timing and intensity.…”

Recipient-derived angiogenesis with short term immunosuppression increases bone remodeling in bone vascularized composite allotransplantation: A pilot study in a swine tibial defect model

“…As both blood type and the major histocompatibility haplotypes (the swine leucocyte antigen or SLA complex) have been well defined, the mini pig is proving of value for study of many VCA tissues . A limitation of the swine model is its rapid growth .…”

“…Experimental bone VCA investigations are sparse . In this report, we describe both the gross mechanical strength (compressive loading of bone cross‐sections) as well as nanoindentation characterization of porcine tibial allotransplants.…”

Lymph Node Inclusion in a Modified Osteomyocutaneous Allograft for Vascularized Composite Allotransplantation: Establishment and Feasibility Assessment in a Pig Model

“…Although the main idea behind the various modifications of the described orthotopic forelimb VCA model 16 , 17 , 30 was to test the flap’s function at an endpoint, the only functional outcome that could be assessed was joint stability by manual manipulation of the joint. However, innervation and sensation could also be theoretically tested.…”

A new porcine vascularized tibial bone allotransplantation model. Anatomy and surgical technique

“…Porcine blood type and SLA haplotypes are known, and permit rigorous evaluation of transplant immunology. Whole limb transplantation and other composite tissues have been studied in swine (Kuo et al, ; Ren et al, ; Ustuner et al, ). Lee et al () demonstrated that various VCA tissue components vary in their effect on cellular and humoral immune response timing and intensity.…”

Recipient-derived angiogenesis with short term immunosuppression increases bone remodeling in bone vascularized composite allotransplantation: A pilot study in a swine tibial defect model

“…As both blood type and the major histocompatibility haplotypes (the swine leucocyte antigen or SLA complex) have been well defined, the mini pig is proving of value for study of many VCA tissues . A limitation of the swine model is its rapid growth .…”

“…Experimental bone VCA investigations are sparse . In this report, we describe both the gross mechanical strength (compressive loading of bone cross‐sections) as well as nanoindentation characterization of porcine tibial allotransplants.…”

Lymph Node Inclusion in a Modified Osteomyocutaneous Allograft for Vascularized Composite Allotransplantation: Establishment and Feasibility Assessment in a Pig Model

“…Although the main idea behind the various modifications of the described orthotopic forelimb VCA model 16 , 17 , 30 was to test the flap’s function at an endpoint, the only functional outcome that could be assessed was joint stability by manual manipulation of the joint. However, innervation and sensation could also be theoretically tested.…”

A new porcine vascularized tibial bone allotransplantation model. Anatomy and surgical technique

“…Porcine blood type and SLA haplotypes are known, and permit rigorous evaluation of transplant immunology. Whole limb transplantation and other composite tissues have been studied in swine (Kuo et al, ; Ren et al, ; Ustuner et al, ). Lee et al () demonstrated that various VCA tissue components vary in their effect on cellular and humoral immune response timing and intensity.…”

Recipient-derived angiogenesis with short term immunosuppression increases bone remodeling in bone vascularized composite allotransplantation: A pilot study in a swine tibial defect model

“…As both blood type and the major histocompatibility haplotypes (the swine leucocyte antigen or SLA complex) have been well defined, the mini pig is proving of value for study of many VCA tissues . A limitation of the swine model is its rapid growth .…”

“…Experimental bone VCA investigations are sparse . In this report, we describe both the gross mechanical strength (compressive loading of bone cross‐sections) as well as nanoindentation characterization of porcine tibial allotransplants.…”