2009
DOI: 10.1111/j.1528-1167.2008.01908.x
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Abstract: SUMMARYPurpose: In the present study we decided to investigate whether physical exercise protects against the electrographic, oxidative, and neurochemical alterations induced by subthreshold to severe convulsive doses of pentyltetrazole (PTZ). Methods: The effect of swimming training (6 weeks) on convulsive behavior induced by PTZ (30, 45, and 60 mg/kg, i.p.) was measured and different electrographic electroencephalography (EEG) frequencies obtained from freely moving rats. After EEG recordings, reactive oxyge… Show more

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Cited by 74 publications
(64 citation statements)
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“…The relationship between physical exercise and epilepsy, especially the underlying mechanism involved therein is still intriguing. Physical activity can play a favourable role in reducing the frequency and intensity of some seizures, as is evident from recent experimental and clinical studies (Souza et al, 2009). According to some clinical studies, aerobic exercise training programs could either decrease (Eriksen et al, 1994) or have no effect on seizure frequency (McAuley et al, 2001).…”
Section: Introductionmentioning
confidence: 92%
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“…The relationship between physical exercise and epilepsy, especially the underlying mechanism involved therein is still intriguing. Physical activity can play a favourable role in reducing the frequency and intensity of some seizures, as is evident from recent experimental and clinical studies (Souza et al, 2009). According to some clinical studies, aerobic exercise training programs could either decrease (Eriksen et al, 1994) or have no effect on seizure frequency (McAuley et al, 2001).…”
Section: Introductionmentioning
confidence: 92%
“…Experimental studies have demonstrated a positive effect of physical exercise in animals with epilepsy (Souza et al 2009, Pietrelli et al, 2012. Although there is convincing evidence indicating that physical exercise has the positive role in reducing the frequency and severity of seizures in several models of experimental epilepsy, this subject is still a matter of controversy.…”
Section: Figurementioning
confidence: 98%
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“…Para determinar el efecto de la natación en la epileptogénesis en ratas se usó el modelo de pentilentetrazol en un estudio realizado en Brasil (33). Se dividió a los animales en ratas sedentarias y atléticas; este último grupo estuvo sometido a una exigencia física variable, al ponerles pesas en la cola durante las sesiones de ejercicio.…”
Section: ¿Es Posible Que El Ejercicio Físico Pueda Prevenir La Epilepunclassified
“…El ejercicio logra moldear los procesos neurobiológicos en dichos animales estableciendo una especie de reserva o resistencia neuronal, que evita la aparición de crisis convulsivas; esta situación ocurre en menor proporción en los ejemplares sedentarios (36)(37)(38). En diferentes modelos animales con epilepsia ya establecida se logra dilucidar que el ejercicio produce cambios bioquímicos y estructurales en diferentes partes del cerebro, que finalmente se relacionan con una disminución de la frecuencia de las crisis epilépticas.…”
Section: ¿Tiene La Actividad Física Algún Impacto En La Aparición De unclassified