Swimming Exercise Ameliorates Symptoms of MOG-Induced Experimental Autoimmune Encephalomyelitis by Inhibiting Inflammation and Demyelination in Rats

Kim, Ji-Youn; Yi, Eun-Surk; Lee, Hyunju; Kim, Junsu; Jee, Yong-Seok; Kim, Sang Hoon; Kim, Chang‐Ju; Ko, Il‐Gyu

doi:10.5213/inj.2040156.078

Cited by 17 publications

(18 citation statements)

References 35 publications

(43 reference statements)

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“…(5) CD8+PD-1+T cells (percentage and absolute value) and CD8+ TIGIT+T (percentage value) of EG were lower than those of CG. These results indicate that the muscle hypertrophy caused by resistance exercise increases the cytotoxicity to human anti-gens and pathogens, including cancer cells.AUTHOR CONTRIBUTION STATEMENT• Conceptualization: JKL • Data curation: JKL • Formal analysis: JKL • Funding acquisition: YSJ • Methodology: JKL • Project administration: YSJ • Visualization: YSJ • Writing-original draft: YSJ • Writing-review & editing: YSJ ORCID Jong-Kyun Lee 0000-0003-1665-0326 Yong-Seok Jee 0000-0001-6797-0843…”

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confidence: 72%

Effect of Resistance Exercise on Acquired Immunocytes in Cancer Survivors: A Pilot Study

Lee

Jee

2021

Int Neurourol J

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Purpose: The purpose of this study was to elucidate the effect of resistance exercise on skeletal muscle mass-related fitness and acquired immune cell function in ovarian cancer survivors.Methods: Twelve ovarian cancer survivors aged 33–61 years participated voluntarily in this study and were divided into control group (CG, n=6) and exercise group (EG, n=6). They underwent removal of ovarian cancer and received regular care for over one year. Resistance exercise was used as the intervention program conducted 4 days a week for 12 weeks. Skeletal muscle mass, muscle strength, and endurance were assessed at baseline and at week 12. Other dependent variables included adaptive immunocytes related to helper T (Th) cells and immunosuppressors (CD4+ and CD8+).Results: After the intervention, skeletal muscle mass showed positive changes in EG com-pared to CG, although not significantly different. Muscle strength and endurance significantly increased in EG, while there was no significant change in CG. Th1, Th2, and Th1/Th2 ratio were significantly different between both groups. CD4+CD25+T cells and CD4+PD-1+T cells of EG were lower than those of CG. CD8+PD-1+T cells and CD8+TIGIT+T of EG were lower than those of CG. These results can be interpreted as the improved sensitivity of CD4+ and CD8+, which helps the secretion of myokines and cytokines, when cytotoxic substances are injected into the human body.Conclusions: This study suggests that resistance training improves upon desirable changes in adaptive immune cell responses in ovarian cancer survivors by maintaining skeletal muscle mass while developing strength and endurance.

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confidence: 72%

Effect of Resistance Exercise on Acquired Immunocytes in Cancer Survivors: A Pilot Study

Lee

Jee

2021

Int Neurourol J

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“…Physical exercise to maintain and improve nerve health can be a very effective treatment strategy for preventing neuroinflammation-related diseases [19]. Lymphocytes increase during and after exercise, and exercise regulates the balance of secretion of proinflammatory and anti-inflammatory cytokines [20,21]. It is well known that physical exercise inhibits the activation of NF-κB signal caused by inflammation [22,23].…”

Section: Discussionmentioning

confidence: 99%

Voluntary Wheel Running Improves Spatial Learning Memory by Suppressing Inflammation and Apoptosis via Inactivation of Nuclear Factor Kappa B in Brain Inflammation Rats

2020

Int Neurourol J

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Purpose: Exercise has been shown to protect against diverse brain diseases. Voluntary exercise improves cognition and has a neuroprotective effect. The aim of this investigation is to study the effect of voluntary wheel running on brain inflammation in rats with regard to inflammation and apoptosis.Methods: Brain inflammation was caused by intracranial injection of lipopolysaccharide using a stereotaxic instrument. Voluntary wheel running group were conducted during 21 consecutive days, staring 2 days after brain inflammation.Results: Brain inflammation increased proinflammatory cytokine production and apoptosis cell death in the hippocampus. There changes in the hippocampus deteriorated spatial learning memory. However, voluntary wheel running suppressed the secretion of inflammatory cytokines and apoptotic neuronal cell death via inactivation of nuclear factor kappa B (NF-κB)/NF-κB inhibitor-α pathway. Voluntary wheel running also promoted the recovery of the spatial learning memory impairment.Conclusions: Voluntary wheel running after brain inflammation enhanced spatial learning memory by suppressing proinflammatory cytokine secretion and apoptosis cell death. Voluntary wheel running is also expected to be effective in inflammatory diseases of the urogenital system.

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“…Western blotting was conducted to determine the expressions of collagen type I and fibronectin at the protein levels in liver tissue in the same manner as previous described method ( Ji et al, 2020 ; Kim et al, 2020 ). The liver tissues were homogenized on ice using a homogenizer, and the supernatants were collected by centrifugation after dissolving the tissues in lysis buffer.…”

Section: Methodsmentioning

confidence: 99%

Study on the pathogenesis of liver injury caused by alcohol and drugs

Kim¹,

Jin

et al. 2021

J Exerc Rehabil

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n the present study, alcohol, lipopolysaccharide (LPS), and carbon tetrachloride (CCL4) were administered to experimental mice. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 concentrations, and collagen type 1alpha (COL-1A) and fibronectin expressions were measured to evaluate pathophysiology of liver injury. Levels of ALT and AST were significantly increased by alcohol treatment. Alcohol with LPS treatment increased ALT and AST levels more than alcohol alone treatment, but it was not statistically significant. Alcohol with CCL4 treatment significantly increased ALT and AST levels more than alcohol alone treatment. Alcohol with LPS and CCL4 treatment significantly increased ALT and AST levels more than alcohol with CCL4 treatment. Concentrations of TNF-α, IL-1β, and IL-6 were significantly enhanced by alcohol treatment. Alcohol with LPS treatment significantly enhanced concentrations of TNF-α, IL-1β, and IL-6 more than alcohol alone treatment. Alcohol with CCL4 treatment significantly enhanced TNF-α, IL-1β, and IL-6 concentrations more than alcohol alone treatment. Alcohol with LPS and CCL4 treatment increased TNF-α, IL-1β, and IL-6 concentrations more than alcohol with CCL4 treatment, but it was not statistically significant. COL-1A and fibronectin expressions were significantly increased by alcohol treatment. Alcohol with LPS treatment significantly increased COL-1A and fibronectin expressions more than alcohol alone treatment. Alcohol with CCL4 treatment significantly increased COL-1A and fibronectin expressions more than alcohol alone treatment. Alcohol with LPS and CCL4 treatment increased COL-1A and fibronectin expressions more than alcohol with CCL4 treatment, but it was not statistically significant.

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Swimming Exercise Ameliorates Symptoms of MOG-Induced Experimental Autoimmune Encephalomyelitis by Inhibiting Inflammation and Demyelination in Rats

Cited by 17 publications

References 35 publications

Effect of Resistance Exercise on Acquired Immunocytes in Cancer Survivors: A Pilot Study

Effect of Resistance Exercise on Acquired Immunocytes in Cancer Survivors: A Pilot Study

Voluntary Wheel Running Improves Spatial Learning Memory by Suppressing Inflammation and Apoptosis via Inactivation of Nuclear Factor Kappa B in Brain Inflammation Rats

Study on the pathogenesis of liver injury caused by alcohol and drugs

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