Swelling of mucoadhesive electrospun chitosan/polyethylene oxide nanofibers facilitates adhesion to the sublingual mucosa

Stie, Mai Bay; Gätke, Johan Ring; Wan, Feng; Chronakis, Ioannis S.; Jacobsen, Jette Bredahl; Nielsen, Hanne Mørck

doi:10.1016/j.carbpol.2020.116428

Cited by 39 publications

(17 citation statements)

References 32 publications

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“…Mucoadhesive CS-based electrospun nanofibers have been reported to be promising candidates for overcoming challenges associated with sublingual drug delivery. For example, Stie et al [198] focused on the elucidation of the mucoadhesive properties of chitosan/polyethylene oxide (PEO) nanofibers. They studied how the degree of deacetylation (DDA, 53-96%) of CS influenced their morphological and mucoadhesive properties.…”

Section: Buccal Drug Deliverymentioning

confidence: 99%

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Mikušová

Mikuš

2021

IJMS

244

120

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Nanoparticles (NPs) have an outstanding position in pharmaceutical, biological, and medical disciplines. Polymeric NPs based on chitosan (CS) can act as excellent drug carriers because of some intrinsic beneficial properties including biocompatibility, biodegradability, non-toxicity, bioactivity, easy preparation, and targeting specificity. Drug transport and release from CS-based particulate systems depend on the extent of cross-linking, morphology, size, and density of the particulate system, as well as physicochemical properties of the drug. All these aspects have to be considered when developing new CS-based NPs as potential drug delivery systems. This comprehensive review is summarizing and discussing recent advances in CS-based NPs being developed and examined for drug delivery. From this point of view, an enhancement of CS properties by its modification is presented. An enhancement in drug delivery by CS NPs is discussed in detail focusing on (i) a brief summarization of basic characteristics of CS NPs, (ii) a categorization of preparation procedures used for CS NPs involving also recent improvements in production schemes of conventional as well as novel CS NPs, (iii) a categorization and evaluation of CS-based-nanocomposites involving their production schemes with organic polymers and inorganic material, and (iv) very recent implementations of CS NPs and nanocomposites in drug delivery.

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Section: Buccal Drug Deliverymentioning

confidence: 99%

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Mikušová

Mikuš

2021

IJMS

244

120

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“…For example, the solvent of chitosan is generally toxic or an irritating liquid such as acetic acid, trifluoroacetic acid, HFIP, CF, etc. ; there are fiber beads in the process of electrospinning chitosan; the mechanical properties of the nanofibers are weak [ 114 , 115 , 116 ]. To avoid the use of toxic or irritating solvents such as HFIP, CF, TFA, and acetic acid, chitosan can be modified and made water-soluble.…”

Section: Antibacterial Materialsmentioning

confidence: 99%

Application of Electrospinning in Antibacterial Field

Chen

et al. 2021

Nanomaterials

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In recent years, electrospun nanofibers have attracted extensive attention due to their large specific surface area, high porosity, and controllable shape. Among the many applications of electrospinning, electrospun nanofibers used in fields such as tissue engineering, food packaging, and air purification often require some antibacterial properties. This paper expounds the development potential of electrospinning in the antibacterial field from four aspects: fiber morphology, antibacterial materials, antibacterial mechanism, and application fields. The effects of fiber morphology and antibacterial materials on the antibacterial activity and characteristics are first presented, then followed by a discussion of the antibacterial mechanisms and influencing factors of these materials. Typical application examples of antibacterial nanofibers are presented, which show the good prospects of electrospinning in the antibacterial field.

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“…However, the highest swelling ratio was achieved under acidic pH (4.01) conditions for the CS/PEO but the water sorption in solutions after 24 h showed that the swelling ratio of the composite nanofiber membranes decreased. This observed weight loss could be because CS with very high DDA may be dispersible in a slightly acidic medium (pH < 6) or due to some small quantity of the CS/PEO becoming soluble [59].…”

Section: Swelling Behavior Of the Composite Nanofiber Membranementioning

confidence: 99%

Chitosan/PEO nanofibers electrospun on metallized track-etched membranes: fabrication and characterization

Pereao

Uche

Bublikov

et al. 2021

Materials Today Chemistry

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The development of next-generation adsorption, separation, and filtration materials is growing with an increased research focus on polymer composites. In this study, a novel blend of chitosan (CS) and polyethylene oxide (PEO) nanofiber mats was electrospun on titanium (Ti)-coated polyethylene terephthalate (PET) track-etched membranes (TMs) with after-treatment by glutaraldehyde in the vapor phase for enhancing the nanofiber stability by crosslinking. The prepared composite, titanium-coated track-etched nanofiber membrane (TTM-CPnf) was characterized by Fourier transform infra-red (FTIR), water contact angle, and scanning electron microscopy (SEM) analyses. Smooth and uniform CS nanofibers with an average fiber diameter of 156.55 nm were produced from a 70/30 CS/PEO blend solution prepared from 92 wt. % acetic acid and electrospun at 15 cm needle to collector distance with 0.5 mL/h flow rate and an applied voltage of 30 kV on the TTM-CPnf. Short (15 min) and long (72 h)-term solubility tests showed that after 3 h, crosslinked nanofibers were stable in acidic (pH ¼ 3), basic (pH ¼ 13), and neutral (pH ¼ 7) solutions. The crosslinked TTM-CPnf material was biocompatible based on the low mortality of freshwater crustaceans Daphnia magna. The composite membranes comprised of electrospun nanofiber and TMs proved to be biocompatible and may thus be suitable for diverse applications such as dual adsorptionefiltration systems in water treatment.

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Swelling of mucoadhesive electrospun chitosan/polyethylene oxide nanofibers facilitates adhesion to the sublingual mucosa

Cited by 39 publications

References 32 publications

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Application of Electrospinning in Antibacterial Field

Chitosan/PEO nanofibers electrospun on metallized track-etched membranes: fabrication and characterization

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