Swellable floating tablet based on spray-dried casein nanoparticles: Near-infrared spectral characterization and floating matrix evaluation

Potential of Casein as a Carrier for Biologically Active Agents

“…Cross-linked casein nanoparticles were recently used for preparation of swellable floating tablets [95]. Alfuzosin hydrochloride was dissolved directly in casein solution, and genipin in ethanol was added to achieve cross-linking.…”

“…Alfuzosin hydrochloride was dissolved directly in casein solution, and genipin in ethanol was added to achieve cross-linking. Nanoparticles were obtained by spray-drying [95, 96]. Powdered nanoparticles were then tableted using a single-punch tablet press.…”

“…Casein-based tablets floated much faster than marketed ones. Both formulations prolonged alfuzosin release for 24 h [95], whereas drug release could be modulated by altering the cross-linking degree in the case of the casein tablets [95, 96]. …”

Going Natural: Using polymers from nature for gastroresistant applications

“…Mainly four casein phosphoproteins exist in cow milk, α(S1 and S2)-, β-and κ-casein, in an approximate proportion of 4:1:4:1 respectively, with a molecular weight of 19 to 25 kDa and an isoelectric point between 4.6 and 4.8 (Elzoghby et al, 2011). Casein has been widely explored for a range of pharmaceutical applications, for example in producing hydrogels for drug delivery (Li et al, 2014;Song et al, 2010;Song et al, 2009;Zhang et al, 2015), floating devices for gastroretentive formulations (Bulgarelli et al, 2000;Elzoghby et al, 2015;Mishra et al, 2008) and drugcasein compacts to improve drug solubility (Gubbins et al, 2003;Corrigan, 1991, 1993). Moreover, several recent studies have reported casein-based nano-vehicles for oral delivery of folic acid (Penalva et al, 2015), anticancer agents (Shapira et al, 2010a;Shapira et al, 2012;Shapira et al, 2010b) and other compounds (Bachar et al, 2012;Esmaili et al, 2011;Luo et al, 2015).…”

Near Infrared Spectroscopy: Basic principles and use in tablet evaluation

“…As NIR bands are mixtures of overtones and combinations, the intensity of the absorbance at particular wavelengths do not necessarily respond linearly to a change in concentration of analyte in pharmaceutical products (Roggo et al, 2007) Considering quantitative analysis of active ingredients in tablets, the reflectance mode, mainly used in early work, may have some limitations, since it covers only a certain part of the tablet Current methods of hardness testing involve use of Erweka hardness tester, Strong-kobb testers, are destructive in nature and often subject to operator error (Elzoghby et al, 2015). NIR spectroscopy, on the other hand, offers the opportunity for fast and nondestructive hardness measurements, and provides additional information on structural features of the tablet matrix.…”