Sweeteners and Beta-Glucans Improve Metabolic and Anthropometrics Variables in Well Controlled Type 2 Diabetic Patients

Reyna, Nadia; Cano, Clímaco; Bermúdez, Valmore; Medina, Mayerlim; Souki, Aida; Ambard, M; Nuñez, Maryluz; Ferrer, Mary Ann; Inglett, George E.

doi:10.1097/00045391-200311000-00010

Cited by 61 publications

(46 citation statements)

References 13 publications

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“…The result was greater reductions in HbA1c, weight, and BMI for the experimental diet group. 55 The experimental diet, however, differed from the control diet in fat replacer and fructose content, and sucralose content, as well, and therefore it is not possible to determine the separate contribution of the sucralose content to the study effects. The submission to the US Food and Drug Administration to designate stevia extract, rebaudioside A, also known as rebiana, with Generally Recognized As Safe status noted the lack of effects on blood glucose.…”

Section: Diabetes Mellitus and Glycemic Responsementioning

confidence: 99%

Nonnutritive Sweeteners: Current Use and Health Perspectives

Gardner¹,

Wylie‐Rosett²,

Gidding³

et al. 2012

Circulation

186

121

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Section: Diabetes Mellitus and Glycemic Responsementioning

confidence: 99%

Nonnutritive Sweeteners: Current Use and Health Perspectives

Gardner¹,

Wylie‐Rosett²,

Gidding³

et al. 2012

Circulation

186

121

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“…Sweetness was equalized for all treatments except the water control by the addition of 54, 52, 27, and 480 g sucralose to the F20:G80, sucrose, HFCS, and sweetened control solutions, respectively. Sucralose was chosen as a noncaloric sweetener because it has no interaction with carbohydrate metabolism, BG, blood fructose, or insulin secretion and has no effect on the central nervous system (17,18). To reduce sweetness and improve palatability, lemon juice (Equality; The Great Atlantic and Pacific Company of Canada Ltd, Toronto, Canada) was added.…”

Section: Study Design and Treatmentsmentioning

confidence: 99%

Effects of glucose-to-fructose ratios in solutions on subjective satiety, food intake, and satiety hormones in young men

Akhavan

Anderson

2007

The American Journal of Clinical Nutrition

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Background:The greater prevalence of obesity and the metabolic syndrome in the past 35 y has been attributed to the replacement of sucrose in the food supply with high-fructose corn syrup (HFCS). Objective: Two experiments were conducted to determine the effect of solutions containing sucrose, HFCS, or various ratios of glucose to fructose (G:F) on food intake (FI), average appetite (AA), blood glucose (BG), plasma insulin, ghrelin, and uric acid (UA) in men. Design: Sugar solutions (300 kcal/300 mL) were (in %) G20:F80, HFCS 55 (G45:F55), sucrose, and G80:F20 (experiment 1, n ҃ 12) and G20:F80, G35:F65, G50:F50, sucrose, and G80:F20 (experiment 2, n ҃ 19). The controls were a sweet energy-free control (experiment 1) and water (both experiments). Solutions were provided in a repeated-measures design. AA, BG, and FI were measured in all subjects. Hormonal responses and UA were measured in 7 subjects in experiment 2. Measurements were taken from baseline to 75 min. FI was measured at 80 min. Results: Sucrose and HFCS (experiment 1) and sucrose and G50: F50 (experiment 2) had similar effects on all dependent measures. All sugar solutions similarly reduced the AA area under the curve (AUC). FI and plasma UA concentrations were significantly (P 0.05) lower after high-glucose solutions than after low-glucose solutions. The lower FI was associated with a greater BG AUC (P 0.05) and smaller AA and ghrelin AUCs (P 0.01). Insulin and BG AUCs were positively associated (P 0.001). Conclusion: Sucrose, HFCS, and G50:F50 solutions do not differ significantly in their short-term effects on subjective and physiologic measures of satiety, UA, and FI at a subsequent meal.

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“…The authors stress that there is a dearth of longitudinal studies where the beneficial effects can be better evaluated (36). A possible mechanism to explain this effect could be that the gelatinous layer created by the beta-glucans prevents the enterocytes from absorbing glucose (37). There are also reports of a decrease in insulin resistance in obese women who ingest high doses of beta-glucans (38).…”

Section: Discussionmentioning

confidence: 99%

Effects of oat bran and nutrition counseling on the lipid and glucose profile and anthropometric parameters of hypercholesterolemia patients

et al. 2016

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Antecedentes: con el fin de prevenir la enfermedad crónica, no transmisible, es esencial que el estilo de vida se modifique para incluir una dieta alta en fibra.Objetivo: evaluar el efecto de la harina de avena (DE) en conjunto con consejos de nutrición (NC) sobre el perfil lipídico y glucémico, los parámetros antropométricos, la calidad de la dieta, y la ingestión de alimentos ultraprocesadas (UPF) y aditivos en los enfermos de hipercolesterolemia.Método: se realizó un ensayo de 90 días, doble ciego, controlado con placebo, aleatorizado realizado en 132 hombres y mujeres con c-LDL ≥ 130 mg / dl. Los participantes fueron clasificados en dos grupos: DE Group (OBG) y el grupo placebo (PLG), y se les dio NC y 40 g de DE o de harina de arroz, respectivamente. Se evaluó el perfil lipídico y la glucemia, así como los datos antropométricos, la calidad de la dieta (Índice de Calidad de la dieta revisada para la población brasileña ICD-R) y si se consumieron UPF o aditivos.Resultados: ambos grupos mostraron una disminución significativa en los parámetros antropométricos y la presión arterial, así como una reducción significativa en el colesterol total y LDL. También hubo una mejora en la ICD-R en ambos grupos y una disminución en el consumo de la UPF. La glucemia, HOMA-IR, y QUICKI fueron significativas en inferiores sólo en el grupo que consumió salvado de avena.Conclusión: nuestros hallazgos sobre las modificaciones en el perfil lipídico y en los parámetros antropométricos significan que los consejos nutricionales tienen un efecto beneficioso, que es atribuible a la mejoría en la calidad de la dieta y al menor consumo de alimentos ultraprocesados. El consumo diario de 40 g de salvado de avena proporciona un beneficio adicional, al disminuir los parámetros de resistencia insulínica.

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Sweeteners and Beta-Glucans Improve Metabolic and Anthropometrics Variables in Well Controlled Type 2 Diabetic Patients

Abstract: A diet incorporating a fat replacer and non-sucrose sweeteners produced a greater improvement in metabolic and anthropometric variables in well controlled type 2 diabetic patients when compared with a diet based on American Diabetic Association's nutrition recommendations.

Cited by 61 publications

References 13 publications

Nonnutritive Sweeteners: Current Use and Health Perspectives

Nonnutritive Sweeteners: Current Use and Health Perspectives

Effects of glucose-to-fructose ratios in solutions on subjective satiety, food intake, and satiety hormones in young men

Effects of oat bran and nutrition counseling on the lipid and glucose profile and anthropometric parameters of hypercholesterolemia patients

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