Sweet's Syndrome and Erythema Nodosum

Waltz, Karen M.; Long, David P.; Marks, James G.; Billingsley, Elizabeth M.

doi:10.1001/archderm.135.1.62

Cited by 56 publications

(12 citation statements)

References 37 publications

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“…In recurrent disease, therapy with colchicine, potassium iodide, dapsone, doxycycline, non-steroidal anti-inflammatory agents and cyclosporine has been described, with mixed results [29]. A few case reports mention successful use of infliximab (5 mg/kg) on a compassionate use basis in refractory SS.…”

Section: Discussionmentioning

confidence: 99%

Severe Sweet's Syndrome with Elevated Cutaneous Interleukin-1β after Azathioprine Exposure: Case Report and Review of the Literature

Imhof¹,

Meier²,

Frei

et al. 2015

Dermatology

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Sweet's syndrome (SS) is a dermatosis with systemic symptoms characterized by tender, red nodules or papules, occasionally covered with vesicles, pustules or bullae, usually affecting the upper limbs, face and neck. SS is frequently observed in patients with leukemia or connective tissue diseases, while it is rather seldom in patients with inflammatory bowel disease. The exact pathogenesis of SS is only partially understood. We report the case of a 50-year-old patient with indeterminate colitis, presenting with a febrile diffuse papulopustular and necrotizing skin eruption that healed with significant scarring and appeared 14 days after onset of treatment with azathioprine. Histological examination revealed the presence of features typical of SS, gene expression analysis very high levels of interleukin-1β (IL-1β) mRNA in lesional skin, and immunohistochemistry high levels of IL-1β at the protein level. SS associated with azathioprine is being increasingly reported and is reviewed herein.

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Section: Discussionmentioning

confidence: 99%

Severe Sweet's Syndrome with Elevated Cutaneous Interleukin-1β after Azathioprine Exposure: Case Report and Review of the Literature

Imhof¹,

Meier²,

Frei

et al. 2015

Dermatology

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“…These lesions can clinically be almost indistinguishable (fig. 2) [37,38,39], but at histopathological examination typical signs of SS can be identified, i.e. a pronounced dermal edema and dense neutrophilic infiltration (fig.…”

Section: Methodsmentioning

confidence: 99%

Sweet’s Syndrome – An Extraintestinal Manifestation in Inflammatory Bowel Disease

Ytting¹,

Vind²,

Bang

et al. 2005

Digestion

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Background/Aims: Sweet’s syndrome (SS) is a severe dermatosis that may be an extraintestinal manifestation of inflammatory bowel disease (IBD). Worldwide, 35 cases of SS associated with IBD have been reported. We present the first case of severe, recurrent SS in combination with amebic infection and ulcerative colitis complicated with multiple other extraintestinal manifestations. Methods: Disease course was monitored by serum YKL-40 and C-reactive protein (CRP), white blood cell count, albumin and the Simple Clinical Colitis Activity Index (SSCAI). The amebic infection was diagnosed by direct microscopy of wet mount scrapings sampled by repetitive sigmoidoscopies. Results: The patient was diagnosed with left-sided ulcerative colitis and SS combined with extraintestinal manifestations: arthropathies, iridocyclitis and erythema nodosum. Cysts of Entamoeba histolytica were detected in the stools in two separate periods of time. Serum YKL-40 increased prior to CRP and correlated with disease activity, SCCAI, CRP, white blood cell count and inversely with serum albumin. Conclusion: This case gives further support for SS being an extraintestinal manifestation of ulcerative colitis. YKL-40 may be useful in monitoring the disease course of IBD.

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“… 5 It may appear as an isolated event or simultaneously with a classical Sweet’s syndrome. 5 , 11 , 12 The second type is a pure lobular neutrophilic infiltration of subcutaneous fat (neutrophilic panniculitis). 5 , 13 Several reports have been published regarding neutrophilic dermatoses presenting as facial or periorbital edematous plaques, sometimes simulating facial cellulitis.…”

Section: Discussionmentioning

confidence: 99%

“…Collagenous colitis is an inflammatory bowel disease 1 characterized by normal macroscopic morphology of the colonic mucosa but having a specific histological feature: a collagen band deposition in the lamina propria. 2 Although collagenous colitis has been linked to several neutrophilic dermatoses, 3 – 12 we have found no reports in the literature associating the disorder with Sweet’s syndrome and/or neutrophilic panniculitis. We describe the case of a woman who developed Sweet’s syndrome and a neutrophilic infiltrate, mainly confined to the panniculus, during periods of collagenous colitis activity.…”

Section: Introductionmentioning

confidence: 87%

Neutrophilic dermatoses in a patient with collagenous colitis

et al. 2010

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We report the case of a 75-year old woman with collagenous colitis who presented with erythematous and edematous plaques on the periorbital and eyelid regions, accompanied by oral ulcers. Histopathology showed a dermal neutrophilic infiltrate plus mild septal and lobular panniculitis with lymphocytes, neutrophils and eosinophils. Five years earlier she had presented a flare of papules and vesicles on the trunk, together with oral ulcers; a skin biopsy revealed a neutrophilic dermal infiltrate and Sweet’s syndrome was diagnosed. Both the neutrophilic panniculitis and the Sweet’s syndrome were accompanied by fever, malaise and diarrhea. Cutaneous and intestinal symptoms disappeared with corticoid therapy. The two types of neutrophilic dermatoses that appeared in periods of colitis activity suggest that intestinal and cutaneous manifestations may be related.

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Sweet's Syndrome and Erythema Nodosum

Cited by 56 publications

References 37 publications

Severe Sweet's Syndrome with Elevated Cutaneous Interleukin-1β after Azathioprine Exposure: Case Report and Review of the Literature

Severe Sweet's Syndrome with Elevated Cutaneous Interleukin-1β after Azathioprine Exposure: Case Report and Review of the Literature

Sweet’s Syndrome – An Extraintestinal Manifestation in Inflammatory Bowel Disease

Neutrophilic dermatoses in a patient with collagenous colitis

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