Sustained Release of Ibuprofen from Polyelectrolyte Encapsulated Mesoporous Carriers

Sörensen, MH; Samoshina, Yulia; Claesson, PM; Alberius, Pca

doi:10.1080/01932690802644095

Cited by 12 publications

(6 citation statements)

References 38 publications

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“…Previous studies have used different organic solvents to achieve the loading of Ibuprofen into mesostructured silica, while in the current study we have developed a method based on CO 2 (l). [3][4][5][6] Using liquid carbon dioxide (or other liquefied gases) has several advantages over the traditional organic solvents, especially since no solvent residues will be left in the final material, which may be an issue if the material should be used in high-purity applications, such as drugs. Another advantage is that it is not necessary to add extra steps in the process for drying the final material and the material can be processed at mild conditions (T C = 31 • C and p C = 73 bar).…”

Section: Introductionmentioning

confidence: 99%

Ibuprofen loading into mesostructured silica using liquid carbon dioxide as a solvent

Hillerström

Stam

Andersson³

2009

Green Chem.

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It has been demonstrated that the pharmaceutical molecule, Ibuprofen, can be loaded into mesoporous silica using liquid (near-critical) carbon dioxide as the solvent, and that the resulting material had a high Ibuprofen content (300 mg Ibuprofen/g SiO 2 ). A high enrichment (300 times) of Ibuprofen in the pores was observed in comparison to the Ibuprofen concentration in the solution. When similar experiments were performed in CO 2 (l) mixed with minor amounts (5 mol-%) of other organic cosolvents (cyclohexane, acetone or methanol), a significantly lower loading capacity of Ibuprofen into the mesoporous material was achieved. The drug-loaded mesoporous silica material was analyzed with Thermogravimetric Analysis (TGA), confocal Raman microscopy, X-ray Powder Diffraction (XRPD) and Scanning Electron Microscopy (SEM). It was found that the Ibuprofen loaded into the mesoporous silica host was amorphous and that Ibuprofen was present both at the surface and in the centre of the mesoporous silica particles. Furthermore, the SEM images did not reveal any large flakes of Ibuprofen molecules outside the mesoporous silica particles.

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Section: Introductionmentioning

confidence: 99%

Ibuprofen loading into mesostructured silica using liquid carbon dioxide as a solvent

Hillerström

Stam

Andersson³

2009

Green Chem.

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“…Depending on the ionizable groups present such as those that are acidic (e.g., carboxylic, phosphoric, sulfonic) or basic (amino groups), a polyelectrolyte can be classifi ed as a polyacid, polybase, or polyampholyte [ 143 ]. The application of polyelectrolytes in the fi eld of EAP-based bioactive delivery is of pertinence based on their structural response to pH, temperature, and electrical current alterations [ 144 ]. DNA is a polyelectrolyte, thus indicating the potential for synthesizing biocompatible polyelectrolytes [ 11 ].…”

Section: Eap-based Polyelectrolyte Hydrogels In the Delivery Of Biolomentioning

confidence: 99%

Electroactive Polymers and Coatings

Toit

Kumar

Choonara

et al. 2016

Industrial Applications for Intelligent Polymers and Coatings

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Electroactive polymers (EAPs) and coatings (EACs) provide an expanding and progressive frontier for responsive drug delivery and the design of biomedical devices. EAPs possess the distinctive propensity to undergo a change in shape and/or size following electrical current activation. Current interest in EAPs and EACs extends to use in controlled drug delivery applications, where an "on-off" mechanism for drug releases would be optimal, as well as application in a biomedical devices and implants. This chapter explores and molecularly characterizes various EAPs such as polyaniline, polypyrrole, polythiophene, and polyethylene, which can ultimately be incorporated into responsive hydrogels in conjunction with, for example, a desired bioactive, to obtain a stimulus-controlled bioactive release system, which can be actuated by the patient, for enhanced specifi city. The institution of hybrids of conducting polymers and hydrogels has also been subjected to increasing investigation as soft EACs, which have been applied, for example, in the improvement of the mechanical and electrical performance of metallic implant electrodes. The various interconnected aspects of EAP-based systems, including their synthesis, proposed modus operandi , physical properties, as well as functionalization approaches for enhancing the performance of these systems, are delineated. The use and comparison of these EAPs and EACs alone, and in conjunction with hydrogels, is further elaborated, together with strategies for integrating electroactive components and hydrogels. Approaches for modeling and explaining the proposed modus operandi of these systems are delineated. A critical review of diverse biomedical systems implementing EAPs and EACs having application in the pharmaceutical and medical industry, specifi cally, is provided, highlighting their applications, potential advantages, and possible limitations. Ultimately, this chapter illuminates innovative approaches for enabling EAP-and EAC-based systems to attain their full clinical potential.

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“…The type of the polyelectrolyte as per the above classification is determined by its ionizable groups, that is, depending on whether it is acidic group such as carboxylic, sulfonic, or phosphoric groups or basic groups such as amino groups . What makes these hydrogels important in the field of EAP‐based drug delivery is its structural response that is often induced by a change in pH, temperature and even electrical current . The human body structures such as DNAs are polyelectrolyte, and therefore, it is possible to synthesize polyelectrolytes that are biocompatible.…”

Section: The Application Of Polyelectrolytes For the Delivery Of Biolmentioning

confidence: 99%

“…166 What makes these hydrogels important in the field of EAPbased drug delivery is its structural response that is often induced by a change in pH, temperature and even electrical current. 167 The human body structures such as DNAs are polyelectrolyte, and therefore, it is possible to synthesize polyelectrolytes that are biocompatible. Biodegradable polyelectrolytes have also been investigated as a pulmonary drug delivery system that may be a desirable route for vaccine delivery.…”

Section: The Application Of Polyelectrolytes For the Delivery Of Biolmentioning

confidence: 99%

A review of integrating electroactive polymers as responsive systems for specialized drug delivery applications

Pillay

Tsai

Choonara

et al. 2013

J Biomedical Materials Res

102

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Electroactive polymers (EAPs) are promising candidate materials for the design of drug delivery technologies, especially in conditions where an "on-off" drug release mechanism is required. To achieve this, EAPs such as polyaniline, polypyrrole, polythiophene, ethylene vinyl acetate, and polyethylene may be blended into responsive hydrogels in conjunction with the desired drug to obtain a patient-controlled drug release system. The "on-off" drug release mechanism can be achieved through the environmental-responsive nature of the interpenetrating hydrogel-EAP complex via (i) charged ions initiated diffusion of drug molecules; (ii) conformational changes that occur during redox switching of EAPs; or (iii) electroerosion. These release mechanisms are not exhaustive and new release mechanisms are still under investigation. Therefore, this review seeks to provide a concise incursion and critical overview of EAPs and responsive hydrogels as a strategy for advanced drug delivery, for example, controlled release of neurotransmitters, sulfosalicyclic acid from cross-linked hydrogel, and vaccine delivery. The review further discusses techniques such as linear sweep voltammetry, cyclic voltammetry, impedance spectroscopy, and chronoamperometry for the determination of the redox capability of EAPs. The future implications of the hydrogel-EAP composites include, but not limited to, application toward biosensors, DNA hybridizations, microsurgical tools, and miniature bioreactors and may be utilized to their full potential in the form of injectable devices as nanorobots or nanobiosensors.

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Sustained Release of Ibuprofen from Polyelectrolyte Encapsulated Mesoporous Carriers

Cited by 12 publications

References 38 publications

Ibuprofen loading into mesostructured silica using liquid carbon dioxide as a solvent

Ibuprofen loading into mesostructured silica using liquid carbon dioxide as a solvent

Electroactive Polymers and Coatings

A review of integrating electroactive polymers as responsive systems for specialized drug delivery applications

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