Sustained-release of buspirone HCl by co spray-drying with aqueous polymeric dispersions

Al-Zoubi, Nizar; AlKhatib, Hatim S.; Bustanji, Yasser; Aiedeh, Khaled; Malamataris, S.

doi:10.1016/j.ejpb.2008.01.002

Cited by 33 publications

(11 citation statements)

References 16 publications

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“…The effect of drug:excipient (D:E) ratio on drug release is shown in Figure 3, for tablets prepared from physical mixtures of drug and Kollidon SR (containing 19% PVP) and from co-spray dried products obtained with Kollicoat SR 30D (containing 9% PVP), without extra addition of PVP. Figure 4 shows the effect of PVP content on drug release for tablets of constant (1:2) D:E ratio prepared from co-spray dried products obtained with Kollicoat SR 30D and additional (increased) PVP content (9,14,19 and 29%) and from physical mixtures of drug, Kollidon SR and PVP (containing 19 and 29% PVP).…”

Section: Resultsmentioning

confidence: 99%

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Sustained release of diltiazem HCl tableted after co-spray drying and physical mixing with PVAc and PVP

Al-Zoubi

Al-obaidi

Tashtoush

et al. 2015

Drug Development and Industrial Pharmacy

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In this work, aqueous diltiazem HCl and polyvinyl-pyrrolidone (PVP) solutions were mixed with Kollicoat SR 30D and spray dried to microparticles of different drug:excipient ratio and PVP content. Co-spray dried products and physical mixtures of drug, Kollidon SR and PVP were tableted. Spray drying process, co-spray dried products and compressibility/compactability of co-spray dried and physical mixtures, as well as drug release and water uptake of matrix-tablets was evaluated. Simple power equation fitted drug release and water uptake (R(2) > 0.909 and 0.938, respectively) and correlations between them were examined. Co-spray dried products with PVP content lower than in physical mixtures result in slower release, while at equal PVP content (19 and 29% w/w of excipient) in similar release (f2 > 50). Increase of PVP content increases release rate and co-spray drying might be an alternative, when physical mixing is inadequate. Co-spray dried products show better compressibility/compatibility but higher stickiness to the die-wall compared to physical mixtures. SEM observations and comparison of release and swelling showed that distribution of tableted component affects only the swelling, while PVP content for both co-spray dried and physical mixes is major reason for release alterations and an aid for drug release control.

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Section: Resultsmentioning

confidence: 99%

“…Its major application is in membrane-controlled drug delivery systems [1][2][3][4][5][6][7] , but however, it has been successfully employed in matrix tablet preparation via fluidized-bed granulation 8 and spray drying 9 .…”

Section: Introductionmentioning

confidence: 99%

Sustained release of diltiazem HCl tableted after co-spray drying and physical mixing with PVAc and PVP

Al-Zoubi

Al-obaidi

Tashtoush

et al. 2015

Drug Development and Industrial Pharmacy

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“…The operation conditions were as follows: inlet air temperature 120°C, outlet air temperature 80°C, spray air pressure 1 kg/cm 2 , and spray feed rate 6 mL/min. The co-agglomerated water-insoluble polymeric nanoparticles which accumulated in the product vessel were collected and kept in screw-capped glass containers until required for examination (Al-Zoubi et al, 2008).…”

Section: Preparation Of Spray-dried Tmh Nanospheresmentioning

confidence: 99%

Development and evaluation of long-acting epidural “smart” thermoreversible injection loaded with spray-dried polymeric nanospheres using experimental design

Kamel¹,

Basha²,

Awdan³

2013

Journal of Drug Targeting

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Context: Reduction of injection frequency as well as localization of drug absorption in the injection site are important requirements in epidural pain treatment. Purpose: Our objective is to explore the production feasibility of controlled release thermoresponsive spray-dried tramadol HCl (TmH) nanospheres for localized epidural injection. Methods: A 2 4 factorial design was employed to study the effect of some selected variables. Results: F15 having the most extended release (MDT = 89.03 ± 0.76 min) was selected, based on regression analysis, for further investigation and characterization. The selected nanospheres (particle diameter = 832.5 ± 10.61 nm) with good flowing properties (θ = 28.076 ± 1.20) was reconstituted with different concentrations of Poloxamer 407 (P407) solution. The optimum reconstituted F15 nanospheres, prepared using 20% w/w P407, was liquid at room temperature, exhibited sol-gel transition at 37°C, was easily withdrawn and injected using 23G needle. The evaluation of the analgesic effect of the selected formula using hot plate method showed a desired rapid onset, yet, extended analgesic effect up to 24 h. The AUC 0-24 h (2998.072 ± 61.830) as well as E max (200.788 ± 12.123) were significantly higher than drug solution and control while T max (2.200 ± 1.095) was non-significant compared to both. Conclusion: the designed formula offers a promising approach as safe depot epidural analgesic.

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“…There are a number of approaches for development of mucoadhesive drug delivery system. A large literature shows the preparation of sustained release microparticles by using spray drying approach [5,6]. A number of studies revealed that initial parameter of spray drying could influence the characteristics of finished product for example particles size increases by increasing the feed rate [7].…”

Section: Introductionmentioning

confidence: 99%

Characterization of furazolidone-chitosan based spray dried microparticles regarding their drug release and mucin adsorptive properties

2016

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Sustained-release of buspirone HCl by co spray-drying with aqueous polymeric dispersions

Cited by 33 publications

References 16 publications

Sustained release of diltiazem HCl tableted after co-spray drying and physical mixing with PVAc and PVP

Sustained release of diltiazem HCl tableted after co-spray drying and physical mixing with PVAc and PVP

Development and evaluation of long-acting epidural “smart” thermoreversible injection loaded with spray-dried polymeric nanospheres using experimental design

Characterization of furazolidone-chitosan based spray dried microparticles regarding their drug release and mucin adsorptive properties

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