Suspected natural lysosomal storage disease from ingestion of pink morning glory (<i>Ipomoea carnea</i>) in goats in northern Argentina

Abstract

This study describes an occurrence of pink morning glory (Ipomoea carnea) intoxication in goats in northern Argentina. The clinical signs displayed by the affected animals were ataxia, lethargy, emaciation, hypertonia of the neck muscles, spastic paresis in the hind legs, abnormal postural reactions and death. The clinico-pathologic examination revealed that the affected animals were anemic and their serum level of aspartate aminotransferase was significantly increased. Cytoplasmic vacuolation in the Purkinje cells and pancreatic acinar cells was observed by histological examination. The neuronal lectin binding pattern showed a strong positive reaction to WGA (Triticum vulgaris), sWGA (succinylated T. vulgaris) and LCA (Lens culinaris). Although I. carnea is common in tropical regions, this is the first report of spontaneous poisoning in goats in Argentina.

Swainsonine-induced lysosomal storage disease in goats caused by the ingestion of Sida rodrigoi Monteiro in North-western Argentina

“…The alphamannosidosis results from deficient activity of the enzyme alphamanosidase and are characterized by intracellular accumulation of oligosaccharides (mainly mannose) (Tulsiani and Touster, 1983). In addition to nervous system, many other tissues could be affected (Elbein, 1989;Stegelmeier et al, 1995Stegelmeier et al, , 2001Driemeier et al, 2000;McLain et al, 2004;Dantas et al, 2006;Stegelmeier et al, 2007;Ríos et al, 2015). In this cases, nervous, pancreatic, hepatic, thyroidal, urinary and myocardial lesions agree with those produced by other plant species that induce lysosomal accumulation due to the presence of swansonine (James et al, 1969;Van Kampen and James, 1970;Driemeier et al, 2000;Dantas et al, 2006;Armi en et al, 2007) The presence of axonal torpedoes was an important finding in the nervous system, especially in the cerebellar tissue.…”

“…Since years several species of Ipomoea sp. have been linked to such diseases (de Balogh et al, 1999;Rodríguez et al, 2004;Armi en et al, 2007;Tokarnia et al, 2012;Ríos et al, 2015). Dantas et al (2006) described similar disease from eating Turbina cordata in Brazil.…”

“…Selected sections of brain were submitted to a lectin histochemistry technique as previously described (Driemeier et al, 2000;Ríos et al, 2015). Sections of cerebellum from healthy goats were used as controls.…”

A Review on Ipomoea Carnea: An Exploration

“…Hairy roots of Ipomoea carnea used as decolourising agent when tested for 25 textile azo dyes, out of which more than ninety percent decolourization was observed in 15 dyes 26 .…”