1993
DOI: 10.1038/ng0793-305
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Abstract: Recent studies have demonstrated that a locus at 11p15.5 confers susceptibility to insulin dependent diabetes mellitus (IDDM). This locus has been shown to lie within a 19 kb region. We present a detailed sequence comparison of the predominant haplotypes found in this region in a population of French Caucasian IDDM patients and controls. Identification of polymorphisms both associated and unassociated with IDDM has allowed us to define further the region of association to 4.1 kb. Ten polymorphisms within this … Show more

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Cited by 244 publications
(189 citation statements)
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“…Young GADA-positive patients had younger age at onset (25 vs 28 years; p<0.0001), lower median BMI (22 vs 29 kg/m 2 ; p<0.0001), were less likely to have a family history of diabetes (23% vs 43%; p=2.8×10 −12 ), were more frequently treated with insulin (93% vs 59%; p= 1.1×10 −57 ) and had lower median fasting plasma C-peptide concentrations (0.23 vs 0.70 nmol/l; p<0.0001) than their GADA-negative counterparts (Table 1). HLA-DQB1, PTPN22 and INS VNTR As expected, young GADA-positive diabetic patients had higher frequency of risk HLA-DQB1 (60% vs 25%; p=9.4×10 −34 ), PTPN22 CT/TT (34% vs 26%; p=0.0023), INS VNTR (class I/I) AA (69% vs 53%; p=1.3×10 −8 ) and INS VNTR (class IIIA/IIIA) CC (75% vs 63%; p=4.3×10 −6 ) genotypes than young GADA-negative patients [36][37][38][39] ( Table 2). TCF7L2 The frequency of type 2 diabetes risk genotypes CT/TT of TCF7L2 (rs7903146) was significantly increased in young GADA-negative (53% vs 43%; p=0.0004) compared with GADA-positive diabetic patients.…”
Section: Resultsmentioning
confidence: 98%
“…Young GADA-positive patients had younger age at onset (25 vs 28 years; p<0.0001), lower median BMI (22 vs 29 kg/m 2 ; p<0.0001), were less likely to have a family history of diabetes (23% vs 43%; p=2.8×10 −12 ), were more frequently treated with insulin (93% vs 59%; p= 1.1×10 −57 ) and had lower median fasting plasma C-peptide concentrations (0.23 vs 0.70 nmol/l; p<0.0001) than their GADA-negative counterparts (Table 1). HLA-DQB1, PTPN22 and INS VNTR As expected, young GADA-positive diabetic patients had higher frequency of risk HLA-DQB1 (60% vs 25%; p=9.4×10 −34 ), PTPN22 CT/TT (34% vs 26%; p=0.0023), INS VNTR (class I/I) AA (69% vs 53%; p=1.3×10 −8 ) and INS VNTR (class IIIA/IIIA) CC (75% vs 63%; p=4.3×10 −6 ) genotypes than young GADA-negative patients [36][37][38][39] ( Table 2). TCF7L2 The frequency of type 2 diabetes risk genotypes CT/TT of TCF7L2 (rs7903146) was significantly increased in young GADA-negative (53% vs 43%; p=0.0004) compared with GADA-positive diabetic patients.…”
Section: Resultsmentioning
confidence: 98%
“…Table 2 shows that individuals with homozygous CC for +1127 INS-PstI had almost a two-fold increased risk of prostate cancer as compared to those with other genotypes (OR ¼ 1.74). As the polymorphism at +1127 INS-PstI and its tightly linked VNTR have been reported to be associated with diabetes (Lucassen et al, 1993), we first stratified the analysis by diabetes status, which was based on self-report. There was a disparity by diabetes status, such that the association between +1127 INS-PstI and prostate cancer was apparent among subjects without diabetes (OR ¼ 2.18) but not among those with diabetes (OR ¼ 1.13).…”
Section: Resultsmentioning
confidence: 99%
“…The allelic variation of VNTR is also associated with the risk of diabetes. It has been found consistently that the class I allele increases the risk of type I diabetes (Julier et al, 1991;Lucassen et al, 1993;Bennett and Todd, 1996). An association between the class III allele and type II diabetes has also been reported (Ong et al, 1999).…”
mentioning
confidence: 92%
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