Susceptibility of clinical isolates of Candida glabrata to new triazoles

Swoboda-Kopeć, Ewa; Wróblewska, Marta; Rokosz, A; Krawczyk, Ewa; Łuczak, M.; Sulik-Tyszka, Beata

doi:10.1016/s0924-8579(02)00385-0

Cited by 6 publications

(3 citation statements)

References 17 publications

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“…On the other hand, itraconazole demonstrated a surprisingly low efficacy against C. albicans isolates. C. glabrata were also resistant to this drug, what had been already reported by Pfaler et al (18) and Swoboda-Kopec (27). Considering the higher prevalence of C. albicans among denture stomatitis patients, these results disagree with Cross et al (6) affirmative regarding the efficacy of itraconazole for the treatment of this pathologic condition.…”

Section: Discussionmentioning

confidence: 77%

Antifungal suscepitibility profile of candida spp. oral isolates obtained from denture wearers

Lyon¹,

Moreira²,

Cardoso³

et al. 2008

Braz. J. Microbiol.

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Denture stomatitis is an inflammatory condition that occurs in denture wearers and is frequently associated with Candida yeasts. Antifungal susceptibility profiles have been extensively evaluated for candidiasis patients or immunosupressed individuals, but not for healthy Candida carriers. In the present study, fluconazole, itraconazole, voriconazole, terbinafine and 5-flucytosin were tested against 109 oral Candida spp. isolates. All antifungal agents were effective against the samples tested except for terbinafine. This work might provide epidemiological information about Candida spp. drug susceptibility in oral healthy individuals.

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Section: Discussionmentioning

confidence: 77%

Antifungal suscepitibility profile of candida spp. oral isolates obtained from denture wearers

Lyon¹,

Moreira²,

Cardoso³

et al. 2008

Braz. J. Microbiol.

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“…[ 22 ] However, a few authors have reported a low efficacy of ICZ against C. albicans and C. glabrata . [ 22 23 24 ] C. tropicalis was resistant to AMB, intermediately sensitive (50%) to CTZ, KCZ but showed 100% sensitivity to FCZ, NST, and VCZ. These reports were contradictory to the findings of Jiang et al .…”

Section: Discussionmentioning

confidence: 99%

Candida species diversity in oral cavity of type 2 diabetic patients and their In vitro antifungal susceptibility

et al. 2018

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Objective:To identify and compare the species variation and Colony Forming Units of the species and antifungal susceptibility from oral rinse samples of individuals in poorly-controlled, moderately-controlled and well controlled diabetes patients with control group.Subjects and Methods:Study group comprised of well-controlled, moderately-controlled and poorly controlled Type II diabetic patients grouped according to the level of glycated hemoglobin concentration with 50 patients in each group and 50 healthy individuals. Oral rinse samples were collected in a sterile container with phosphate-buffered saline and then transported immediately for various mycological investigations and antifungal susceptibility tests. Statistical analysis was performed.Results:There was a significant difference in frequency of Candida in poorly controlled diabetes when compared to moderately controlled diabetes, well controlled diabetes and normal patients (P = 0.045). A higher number of colony count was seen among poorly controlled diabetes than well controlled, moderately controlled and non diabetic subjects. A comparatively low number of non-albicans were seen in healthy individuals. C. albicans showed an increased resistance to fluconazole in DM patients in comparison to control group (P = 0.001). Other species showed a variable sensitivity pattern.Conclusion:The decreased immunity and change in oral habitat in diabetic patients creates a diversification in various species of Candida. These non albicans vary in their susceptibility and pathogenesis. A definite identification of these diverse species in the oral cavity of such patients and their susceptibility mandates proper management to avoid recurrence and drug resistance.

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“…Avian faeces as a potential source of yeast exposure for bird owners and poultry house workers are often discussed ( 2 , 25 ). Due to the increasing number of drug-resistant Candida isolates in humans ( 17 , 26 ), and a lack of research into the antifungal susceptibility of Candida species isolated from turkeys’ intestinal tracts, we decided to address the lack of data. The aim of this study was to determine amphotericin B, fluconazole, itraconazole and voriconazole susceptibility of Candida using the E-test method on isolates from turkeys’ intestinal tracts.…”

Section: Introductionmentioning

confidence: 99%

E-test determination of antifungal susceptibility of Candida species isolated from turkeys

Sokół

Tokarzewski²,

Bobrek

et al. 2020

Journal of Veterinary Research

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IntroductionCandida species are a natural component of the intestinal tract microflora, but in favourable conditions they can cause superficial, mucosal, or even systemic candidiasis. Poultry production might be a source of human drug-resistant yeast infections, including Candida spp. The limited data concerning the antifungal susceptibility of poultry Candida isolates prompted us to carry out research to determine the susceptibility of isolates from turkey intestinal tracts.Method and MaterialsThe beak cavity, crop and cloaca were swabbed of 580 turkeys from 58 flocks in western Poland. The susceptibility tests were conducted using the E-test method with amphotericin B, fluconazole, itraconazole, and voriconazole on 52 isolates of C. albicans, C. catenulata, C. glabrata, C. palmioleophila, C. rugosa, C. krusei and C. lusitaniae.ResultsAll isolates were susceptible to voriconazole. According to the MIC values obtained for amphotericin B and fluconazole, all Candida spp. isolates were classified as susceptible according to the described breakpoints except for C. krusei, which was the only isolate that was amphotericin B-, fluconazole- and itraconazole-resistant. The susceptibility to itraconazole varied: 11 of the Candida isolates were susceptible (21.1%), 29 were dose-dependently susceptible (55.8%), and 12 isolates were resistant (23.1%).ConclusionThere are few resistant strains of Candida in turkeys, and the drug resistance varies. When Candida passes from turkeys to humans, there is a wide range of antifungal treatment options.

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Susceptibility of clinical isolates of Candida glabrata to new triazoles

Cited by 6 publications

References 17 publications

Antifungal suscepitibility profile of candida spp. oral isolates obtained from denture wearers

Antifungal suscepitibility profile of candida spp. oral isolates obtained from denture wearers

Candida species diversity in oral cavity of type 2 diabetic patients and their In vitro antifungal susceptibility

E-test determination of antifungal susceptibility of Candida species isolated from turkeys

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