Susceptibility Loci for Preeclampsia on Chromosomes 2p25 and 9p13 in Finnish Families

Laivuori, Hannele; Lahermo, Päivi; Ollikainen, Vesa; Widén, Elisabeth; Häivä-Mällinen, Leena; Sundström, Helena; Laitinen, Tarja; Kaaja, Risto; Ylikorkala, Olavi; Kere, Juha

doi:10.1086/345311

Cited by 145 publications

(110 citation statements)

References 39 publications

(46 reference statements)

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“…Reports of significant linkages between preeclampsia and loci on several chromosomes have been reported in studies from Iceland, 53 Australia, 54 the Netherlands, 55 and Finland. 56 As with candidate genes, the results are inconsistent. Linkage to chromosome 2 was found in 3 studies.…”

Section: Maternal Fetal/placental Interactions In Preeclampsiamentioning

confidence: 99%

“…Linkage to chromosome 2 was found in 3 studies. 53,54,56 In 2 of these, it could not be excluded that the sites were the same, 53,54 but in the third, the site was clearly different. 56 In the Finnish study, linkage to chromosome 9 was to a site similar to that associated with type 2 diabetes in studies from China and Finland.…”

Section: Maternal Fetal/placental Interactions In Preeclampsiamentioning

confidence: 99%

“…53,54,56 In 2 of these, it could not be excluded that the sites were the same, 53,54 but in the third, the site was clearly different. 56 In the Finnish study, linkage to chromosome 9 was to a site similar to that associated with type 2 diabetes in studies from China and Finland. A recent study indicates expression of highly polymorphic genes relevant to implantation with missense mutations cosegregating with preeclampsia in a chromosomal site identified as related to preeclampsia in Dutch studies.…”

Section: Maternal Fetal/placental Interactions In Preeclampsiamentioning

confidence: 99%

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Preeclampsia

2005

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Abstract-Preeclampsia is a pregnancy complication with serious consequences for mother and infant. The disorder is diagnosed by gestational hypertension and proteinuria but is far more than pregnancy induced hypertension. Preeclampsia is proposed to occur in 2 stages. Key Words: preeclampsia Ⅲ hypertension, pregnancy Ⅲ oxidative stress Ⅲ endothelium P reeclampsia is a pregnancy complication recognized by new-onset gestational hypertension and proteinuria (see definitions below). The disorder affects both mothers and their infants. Once the disease is evident clinically, it can be cured only by delivery. In developed countries, surveillance for preeclampsia through prenatal care allows for early identification and intervention via delivery. This management has changed little in the last 100 years, and it is very effective at reducing maternal mortality. However, maternal morbidity remains great with preeclampsia, which continues to be one of the leading causes for the admission of pregnant women to intensive care units in the developed world. 1 Furthermore, fetal mortality and morbidity is considerable, related to the effects of the disease on the fetus as well as prematurity. The indicated delivery of women to prevent the progression of preeclampsia is responsible for 15% of all preterm births. 2 In developing countries, where inadequate prenatal care limits preeclampsia surveillance, maternal mortality is common, accounting for 50 000 deaths yearly. 3 The hypertensive disorders of pregnancy include hypertension that antedates pregnancy, chronic hypertension, and gestational hypertension occurring uniquely during pregnancy. When the gestational hypertension is accompanied by new-onset proteinuria, the disorder is termed preeclampsia, and when not associated with proteinuria, transient hypertension of pregnancy. If the woman with chronic hypertension also manifests evidence of preeclampsia, this is classified chronic hypertension with superimposed preeclampsia. Eclampsia is the occurrence of seizures in women with preeclampsia. 4 These criteria have been extraordinarily useful to aid in recognizing pregnant women at risk. Greatest risk for mother and baby is present with preeclampsia, and the risk for chronic hypertensive pregnancy is primarily with superimposed preeclampsia. However, the attention to hypertension has, for many years, limited research attention to primarily mechanisms of hypertension. This has not been helpful. In the last 2 decades, appreciation that preeclampsia is a multisystemic syndrome characterized by vasoconstriction, metabolic changes, endothelial dysfunction, activation of the coagulation cascade, and increased inflammatory response, to mention only some of the organ systems involved, has redirected research. 5 As a result, progress in understanding the disorder has accelerated greatly, with attendant optimism for potentially effective treatments. 5 In this article, we consider this recent progress and its clinical implications.

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Section: Maternal Fetal/placental Interactions In Preeclampsiamentioning

confidence: 99%

Section: Maternal Fetal/placental Interactions In Preeclampsiamentioning

confidence: 99%

Section: Maternal Fetal/placental Interactions In Preeclampsiamentioning

confidence: 99%

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Preeclampsia

2005

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“…Em famílias da Austrália e Nova Zelândia, foram identificados dois loci: 2p12 e 2q23 10 . Já em famílias da Finlândia, os loci identificados foram os 2p25 e 9p13 11 . Para a maioria da população, no entanto, a PE parece representar uma desordem genética complexa e ocorre como resultado de numerosas variantes comuns em diferentes loci que, individualmente, têm pequeno efeito, mas coletivamente contribuem para a suscetibilidade à doença 12 .…”

Section: Introductionunclassified

Papel protetor do alelo G do polimorfismo no gene Interleucina 10 (-1082G/A) contra o desenvolvimento de pré-eclâmpsia

Pissetti¹,

Bianco²,

Tanaka³

et al. 2014

Rev. Bras. Ginecol. Obstet.

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“…Se formula la hipótesis de que tales resultados podrían deberse a la presencia de varios genes, con efectos complejos sobre la susceptibilidad a la preeclampsia. De manera alternativa podría considerarse que genes de una misma vía reguladora en la cascada de eventos fisiopatológicos podrían producir fenotipos similares con diferentes posiciones en el mapa genético (118).…”

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Genética de la preeclampsia: una aproximación a los estudios de ligamiento genético.

Zuluaga¹,

Cuartas²,

Londoño³

2004

biomedica

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La preeclampsia es considerada un problema de salud pública debido a su alta prevalencia. Muchas investigaciones coinciden en que su origen se relaciona con la interacción entre factores genéticos y ambientales. Por esta razón, múltiples estudios han explorado tales factores genéticos tratando de identificar regiones cromosómicas y genes candidatos cuyas variantes se relacionen con una mayor susceptibilidad a la enfermedad. Diversos estudios de asociación han identificado algunos genes de susceptibilidad a la preeclampsia, pero los resultados no se han replicado consistentemente en todas las poblaciones, quizá por su complejidad clínica y genética. El levantamiento de mapas de genes y regiones cromosómicas basado en análisis de ligamiento ha mostrado resultados interesantes con algunos marcadores en los cromosomas 2 y 4. En este sentido, hay muchas expectativas con respecto a los genes localizados en tales regiones candidatas, debido a que la identificación de los factores de riesgo genético podría ayudar al entendimiento de esta condición y en proveer claves para su prevención y tratamiento.Palabras clave: preeclampsia, genética, mapa genético, análisis de ligamiento, cromosomas, susceptibilidad genética. Genetics of preeclampsia: an approach to genetic linkage studiesDue to its high prevalence during pregnancies, preeclampsia is considered an important public health problem. Many investigators agree in that its expression is related to the interaction between genetic and environmental factors. Many studies have searched for genetic factors, attempting to identify chromosomal regions or candidate genes whose variants may be related to high preeclampsia susceptibility. Several studies have associated a number of susceptibility genes to preeclampsia, but the results have not been replicated consistently in all populations. Mapping of genes and chromosomal regions by linkage analysis has located potential markers on chromosomes 2 and 4. Identification of the genes located in these candidate regions will pinpoint the genetic risk factors, will lead to a better understanding of the syndrome, and will provide clues for its prevention and treatment. La preeclampsia es un complejo síndrome específico de la segunda mitad del embarazo (>20 semanas) que se caracteriza fisiopatológicamente por fenómenos principales como perfusión orgánica reducida, vasoespasmo y activación de la cascada de la coagulación, cuyo origen radica, al parecer, en alteraciones de la placentación. Las manifestaciones clínicas son, principalmente, hipertensión (140/90 mm Hg) y proteinuria (0,3 g en 24 horas), que desaparecen antes de la 12 a semana posparto. Cuando la hipertensión y la proteinuria se suman a la presencia de convulsiones, constituyen la complicación de la preeclampsia, conocida como eclampsia (1).

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Susceptibility Loci for Preeclampsia on Chromosomes 2p25 and 9p13 in Finnish Families

Cited by 145 publications

References 39 publications

Preeclampsia

Preeclampsia

Papel protetor do alelo G do polimorfismo no gene Interleucina 10 (-1082G/A) contra o desenvolvimento de pré-eclâmpsia

Genética de la preeclampsia: una aproximación a los estudios de ligamiento genético.

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