Susceptibilities of
            <i>Yersinia pestis</i>
            Strains to 12 Antimicrobial Agents

Wong, Jane D.; Barash, Jason R.; Sandfort, R.F.; Janda, J. Michael

doi:10.1128/aac.44.7.1995-1996.2000

Cited by 41 publications

(20 citation statements)

References 5 publications

(2 reference statements)

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“…Y. pestis growth was susceptible to the presence of chloramphenicol, tetracycline, and streptomycin as expected and produced MICs of approximately 4, 2, and 4 μg/mL respectively (Figs. 2A, B & C); these values are consistent with those that have been reported for wild-type virulent isolates (Wong et al, 2000). …”

supporting

confidence: 91%

Rapid identification and antibiotic susceptibility testing of Yersinia pestis using bioluminescent reporter phage

Schofield

Molineux

Westwater

2012

Journal of Microbiological Methods

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The rapid identification and antibiotic susceptibility testing of Yersinia pestis is paramount for a positive prognosis. We previously engineered a Y. pestis-specific ‘bioluminescent’ reporter phage for the identification of Y. pestis. In this study, we generated an improved reporter phage and evaluated the ability of this phage to provide direct and rapid susceptibility testing. Compared to the first generation reporter, the second generation reporter exhibited a 100-fold increase in signal strength, leading to a 10-fold increase in assay sensitivity. Y. pestis antimicrobial testing in the presence of the reporter elicited bioluminescent signals that were drug concentration-dependent, and produced susceptibility profiles that mirrored the standard CLSI method. The phage-generated susceptibility profiles, however, were obtained within hours in contrast to days with the conventional method.

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supporting

confidence: 91%

Rapid identification and antibiotic susceptibility testing of Yersinia pestis using bioluminescent reporter phage

Schofield

Molineux

Westwater

2012

Journal of Microbiological Methods

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“…Plague, being a zoonosis, can be contracted by contact with animals or their parasites 12 and is most often acquired through flea bites, but this disease can also be transmitted by animal scratches or by the inhalation of infected particles from animals having a respiratory infection or during the autopsy of infected animals. 1,21,22 Plague can also be contracted in laboratories in which Y. pestis is handled. 23 Recently, an infection by a non-pathogenic Y. pestis strain in a laboratory was reported.…”

Section: Routes Of Transmissionmentioning

confidence: 99%

Plague: History and contemporary analysis

Raoult

Mouffok

Bitam

et al. 2013

Journal of Infection

110

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“…For a collection of 78 Y. pestis isolates from Vietnam from 1985 to 1993, all were susceptible to 14 commercial antibiotics at 8 g/ml; however, the authors noted that the MICs for several antibiotics commonly used in Vietnam were less effective (26). The most recently screened collection consisted of 92 isolates (not all are from human cases) from California from 1977 to 1998, and 12 commercially available antibiotics were found to be effective at Յ8 g/ml (29).…”

Section: Discussionmentioning

confidence: 99%