Surviving Sepsis Campaign

Rhodes, Andrew; Evans, Laura; Alhazzani, Waleed; Levy, Mitchell M.; Antonelli, Massimo; Ferrer, Ricard; Kumar, Anand; Sevransky, Jonathan E.; Sprung, Charles L.; Nunnally, Mark E.; Cook, Deborah J.; Rubenfeld, Gordon D.; Angus, Derek C.; Annane, Djillali; Beale, Richard; Bellinghan, Geoffrey J.; Bernard, Gordon R.; Chiche, Jean Daniel; Coopersmith, Craig M.; Backer, Daniel De; French, Craig; Fujishima, Seitaro; Gerlach, Herwig; Hidalgo, Jorge; Hollenberg, Steven M.; Jones, Alan M.; Karnad, Dilip R.; Kleinpell, Ruth M.; Koh, Younsuck; Lisboa, Thiago; Machado, Flávia Ribeiro; Marini, John J.; Marshall, John; Mazuski, John E.; McIntyre, Lauralyn; McLean, Anthony S.; Mehta, Sangeeta; Moreno, Rui; Myburgh, John; Navalesi, Paolo; Nishida, Osamu; Osborn, Tiffany M.; Perner, Anders; Plunkett, Colleen M.; Ranieri, Marco; Schorr, Christa; Seckel, Maureen A.; Seymour, Christopher W.; Shieh, Lisa; Shukri, Khalid; Simpson, Steven Q.; Singer, Mervyn; Thompson, B. Taylor; Townsend, Sean R.; Poll, Thomas S. van der; Vincent, Jean Louis; Wiersinga, W. Joost; Zimmerman, Janice L.; Dellinger, R. Phillip

doi:10.1097/ccm.0000000000002255

Cited by 2,166 publications

(746 citation statements)

References 650 publications

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“…Some authors suggest evaluating the inferior vena cava with an ultrasound to assess fluid benefit to help avoid over-resuscitation [15,17]. Lactate may be used as a guide in determining adequate tissue perfusion, though it is not a direct measurement of this marker [14,18]. An important factor in sepsis, as well as antimicrobial stewardship, is to collect appropriate cultures prior to initiation of antimicrobial therapy to prevent sterilization [14].…”

Section: Sepsismentioning

confidence: 99%

“…Lactate may be used as a guide in determining adequate tissue perfusion, though it is not a direct measurement of this marker [14,18]. An important factor in sepsis, as well as antimicrobial stewardship, is to collect appropriate cultures prior to initiation of antimicrobial therapy to prevent sterilization [14]. De-escalating therapy is essential in decreasing resistance, side effects, and costs.…”

Section: Sepsismentioning

confidence: 99%

“…In cases where timely collection of specimens is not feasible, it may be more beneficial to administer therapy than to prolong treatment. At least two sets of 20-30 mL of blood per culture, aerobic and anaerobic, should be obtained subsequently within a short interval time due to extreme urgency [14,19]. Once sepsis or septic shock is determined, intravenous (IV) administration of empiric antibiotics is recommended within one hour [14].…”

Section: Sepsismentioning

confidence: 99%

“…The Surviving Sepsis Campaign of 2016 [14] recommends that in the presence of hypoperfusion, fluid resuscitation with a crystalloid be given at a volume of 30 mL kg -1 within the first 3 h, though controversial. It is imperative to modify the volume of fluid resuscitation in identified patients [15].…”

Section: Sepsismentioning

confidence: 99%

“…Some patients may require more, or less, fluid and should be clinically evaluated based on heart rate, blood pressure, oxygen saturation, urine output, capillary refill, appearance of skin mottling, etc. [14,15]. Crystalloid fluid may be given in 500 mL challenges adding up to an initial resuscitation of 20-30 mL kg −1 , measuring responsiveness by an increase in stroke volume [15,16].…”

Section: Sepsismentioning

confidence: 99%

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