Surviving Sepsis Campaign

doi:10.1097/ccm.0000000000000192

Cited by 64 publications

(8 citation statements)

References 19 publications

(18 reference statements)

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“…On the other hand, it could provide important mechanistic information for a supplementation of septic patients with zinc. As implemented by the surviving sepsis campaign (Barochia et al 2013;Dellinger et al 2014) fast and appropriate therapy is the major determining factor for the outcome of sepsis. However, it is difficult to discriminate between sepsis and noninfectious inflammation, especially among surgical patients.…”

Section: Discussionmentioning

confidence: 99%

“…Means that do not share a common letter are significantly different total serum zinc or hematocrit levels. Furthermore volume therapy and hemodynamic monitoring were applied to meet highest clinical standards (Dellinger et al 2014) ensuring realistic conditions. Therefore volume therapy does not seem to have a significant effect on serum trace element levels and can be excluded as a potential reason for the decline of total serum zinc levels.…”

Section: Discussionmentioning

confidence: 99%

“…After 2 h the administered volume was adapted with respect to the continuously central venous pressure (CVP). Thereby the fluid therapy aimed at maintaining a CVP of 10 mmHg in accordance to the surviving sepsis campaign (Dellinger et al 2014).…”

Section: Surgical Procedures and Induction Of Sepsismentioning

confidence: 99%

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Alterations in zinc binding capacity, free zinc levels and total serum zinc in a porcine model of sepsis

et al. 2015

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Zinc is crucial for immune function. In addition, the redistribution of zinc and other nutrients due to infection is an integral part of the host immune response to limit availability to pathogens. However, the major zinc binding protein albumin is down regulated during the acute phase response, implicating a decrease in zinc binding capacity. A prospective animal study with eight female German landrace pigs was conducted to investigate alterations in zinc binding capacity, total serum zinc and free zinc levels in the initial phase of sepsis. Sepsis was induced by instillation of autologous feces via midline laparotomy. Total serum zinc declined significantly after 1 h (10.89 ± 0.42 µM vs. 7.67 ± 0.41 µM, p < 0.001), total serum copper and iron reached a significant reduction at 4 h. Urinary excretion of zinc declined in line with total serum zinc. In comparison to total serum zinc, free zinc levels declined to a lesser, though significant, extent. Zinc binding capacity of serum decreased over time, whereby free zinc levels after addition of zinc correlated negatively with total serum protein and albumin levels. In addition IL-6 and TNF-α concentrations were measured and increased significantly 2 h after induction of sepsis. Hence, total serum zinc was the first marker of inflammation in our experiment, and might therefore be a promising biomarker for the early diagnosis of sepsis. Furthermore the observation of a substantially different serum free zinc homeostasis during sepsis provides valuable information for a potential therapeutic zinc supplementation, which has to take buffering capacity by serum proteins into account.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Alterations in zinc binding capacity, free zinc levels and total serum zinc in a porcine model of sepsis

et al. 2015

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“…Target BP for vasopressors dose titration in post cardiac surgery patients is still controversial. In septic shock, the surviving sepsis campaign settled a target MAP of 65 mmHg [14]. However, some clinicians We found also that the more increase in CVP (% CVP deficit) and percent increase in the deficits of SPP, DPP, and MPP postoperatively compared to pre-operative measurements are associated with the development of AKI.…”

Section: Discussionmentioning

confidence: 87%

Blood Pressure and Blood Pressure Deficits as Predictors of Acute Kidney Injury in Vasopressor Dependent Patients Post Cardiovascular Surgery

Farghaly¹,

Fahmy²,

Ameen³

et al. 2020

Open Access Maced J Med Sci

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BACKGROUND: Acute kidney injury (AKI) is a common and serious post-operative complication following cardiovascular surgery. AIM: The aim of the study was to evaluate the value of blood pressure and blood pressure deficits as predictors of AKI in post cardiovascular surgery vasopressors’ dependent patients. METHODS: A prospective observational, single center study, conducted on 100 patients requiring vasopressor support for more than 4 h after cardiovascular surgery. All included patients were subjected to the measurements of three or more systolic arterial pressure (SAP), diastolic arterial pressure (DAP), and mean arterial pressure (MAP) readings from the ward charts before surgery and the mean of these measures was calculated, was recorded and pre-operative systolic perfusion pressure (SPP), diastolic perfusion pressure (DPP), and mean perfusion pressure (MPP) were calculated. A vasopressor-associated average values for hemodynamic pressure-related parameters (SAP, DAP, MAP, CVP, SPP, DPP, and MPP) were calculated on the 1st 24 h after admission. The percent deficit in post-operative average parameters in relation to pre-operative parameters was determined as % parameter deficit. RESULTS: The pre-operative SAP, DAP, MAP, SPP, DPP, and MPP were significantly higher in the non-AKI compared to AKI patients while pre-operative central venous pressure (CVP) was significantly higher in AKI patients. The post-operative DAP, MAP, DPP, and MPP were also higher in non-AKI and the post-operative CVP was lower in non-AKI compared to AKI patients. CONCLUSIONS: This study concluded that the relative decrease in the perfusion pressures could be significant predictors of AKI after cardiovascular surgery in vasopressor dependent patients. The higher pre- or post-operative CVP or its relative decrease after cardiac surgery was seen also to be associated with higher incidence of AKI.

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“…Taking into account the fact that multiresistant microorganisms are spreading worldwide, the probability to face such a patient is no longer an extraordinary event. The application of the Surviving Sepsis Campaign guidelines [52] and timely administration of antibiotics are often ineffective in these patients due to their frailty and poor immunological status [41]. Therefore, the use of adjunctive therapies for restoring immune function seems to be very promising but, unfortunately, sound evidences are not yet available.…”

Section: Discussionmentioning

confidence: 99%

The Role of Adjunctive Therapies in Septic Shock by Gram Negative MDR/XDR Infections

Busani

Roat

Serafini

et al. 2017

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Patients with septic shock by multidrug resistant microorganisms (MDR) are a specific sepsis population with a high mortality risk. The exposure to an initial inappropriate empiric antibiotic therapy has been considered responsible for the increased mortality, although other factors such as immune-paralysis seem to play a pivotal role. Therefore, beyond conventional early antibiotic therapy and fluid resuscitation, this population may benefit from the use of alternative strategies aimed at supporting the immune system. In this review we present an overview of the relationship between MDR infections and immune response and focus on the rationale and the clinical data available on the possible adjunctive immunotherapies, including blood purification techniques and different pharmacological approaches.

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Surviving Sepsis Campaign

Cited by 64 publications

References 19 publications

Alterations in zinc binding capacity, free zinc levels and total serum zinc in a porcine model of sepsis

Alterations in zinc binding capacity, free zinc levels and total serum zinc in a porcine model of sepsis

Blood Pressure and Blood Pressure Deficits as Predictors of Acute Kidney Injury in Vasopressor Dependent Patients Post Cardiovascular Surgery

The Role of Adjunctive Therapies in Septic Shock by Gram Negative MDR/XDR Infections

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