Survivin is critically involved in VEGFR2 signaling-mediated esophageal cancer cell survival

Meng, L.; Zhu, Fu-Hao; Zhou, Xiaoming; Zheng, Yongri; Ding, Zhaojun; Li, Bingcheng; Xu, Ming; Sun, Shaomei

doi:10.1016/j.biopha.2018.05.134

Cited by 11 publications

(7 citation statements)

References 29 publications

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“…Also, in vivo studies have shown that Survivin was minimally expressed in the endothelium of normal skin, but was significantly upregulated during angiogenesis in newly formed blood vessels in granulation tissue (O'Connor, Schechner, et al, 2000). Meng et al demonstrated that VEGFR signaling upregulated Survivin expression via the AKT/MDM2 pathway and that this was essential for tumor cell survival (Meng, et al, 2018). It has also been shown in glioma cells that Survivin can promote endothelial cell migration and proliferation and also increase microvessel density (a surrogate marker for tumor angiogenesis); moreover, this was attributed to Survivin-induced expression of angiogenic factors VEGF and FGF (P. .…”

Section: Angiogenesismentioning

confidence: 99%

The Multiple Roles of the IAP Super-family in cancer

Kumar

Fairmichael

Longley

et al. 2020

Pharmacology & Therapeutics

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The Inhibitor of Apoptosis proteins (IAPs) are a family of proteins that are mainly known for their anti-apoptotic activity and ability to directly bind and inhibit caspases. Recent research has however revealed that they have extensive roles in governing numerous other cellular processes.IAPs are known to modulate ubiquitin (Ub)-dependent signaling pathways through their E3 ligase activity and influence activation of nuclear factor B (NFB). In this review, we discuss the involvement of IAPs in individual hallmarks of cancer and the current status of therapies targeting these critical proteins.

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Section: Angiogenesismentioning

confidence: 99%

The Multiple Roles of the IAP Super-family in cancer

Kumar

Fairmichael

Longley

et al. 2020

Pharmacology & Therapeutics

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“…In vitro experiments also revealed that some tumor cell lines may express VEGF and VEGFR, allowing VEGF to function as both an autocrine and paracrine factor, which results in a positive feedback loop that directly affects tumor cells [243]. The induction of anti-apoptotic proteins Bcl-2 and survivin, both of which are introduced by VEGF, also play a crucial role in tumor progression by protecting the neovasculature of tumors from apoptosis [244]. Additionally, VEGF promotes the release and activation of extracellular matrix-degrading enzymes such as plasminogen activator and the MMP interstitial collagenase, enabling the unrestricted growth of newly formed blood vessels [245].…”

Section: Vegf Biology In Cancermentioning

confidence: 99%

Hyperthermia in Combination with Emerging Targeted and Immunotherapies as a New Approach in Cancer Treatment

Logghe,

van Zwol,

Immordino

et al. 2024

Cancers

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Despite significant advancements in the development of novel therapies, cancer continues to stand as a prominent global cause of death. In many cases, the cornerstone of standard-of-care therapy consists of chemotherapy (CT), radiotherapy (RT), or a combination of both. Notably, hyperthermia (HT), which has been in clinical use in the last four decades, has proven to enhance the effectiveness of CT and RT, owing to its recognized potency as a sensitizer. Furthermore, HT exerts effects on all steps of the cancer–immunity cycle and exerts a significant impact on key oncogenic pathways. Most recently, there has been a noticeable expansion of cancer research related to treatment options involving immunotherapy (IT) and targeted therapy (TT), a trend also visible in the research and development pipelines of pharmaceutical companies. However, the potential results arising from the combination of these innovative therapeutic approaches with HT remain largely unexplored. Therefore, this review aims to explore the oncology pipelines of major pharmaceutical companies, with the primary objective of identifying the principal targets of forthcoming therapies that have the potential to be advantageous for patients by specifically targeting molecular pathways involved in HT. The ultimate goal of this review is to pave the way for future research initiatives and clinical trials that harness the synergy between emerging IT and TT medications when used in conjunction with HT.

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“…In addition to this, it also transmits its apoptotic effects through the cleavage of Caspase-3 and PARP in OC cells [ 102 ]. And Survivin blocks apoptosis by inhibiting Caspase-3 and Caspase-7 [ 103 ].…”

Section: Pathogenesis Of Ocmentioning

confidence: 99%

Scutellaria baicalensis Georgi and Their Natural Flavonoid Compounds in the Treatment of Ovarian Cancer: A Review

Cai

He³

et al. 2023

Molecules

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Ovarian cancer (OC) is one of the most common types of cancer in women with a high mortality rate, and the treatment of OC is prone to high recurrence rates and side effects. Scutellaria baicalensis (SB) is a herbal medicine with good anti-cancer activity, and several studies have shown that SB and its flavonoids have some anti-OC properties. This paper elucidated the common pathogenesis of OC, including cell proliferation and cell cycle regulation, cell invasion and metastasis, apoptosis and autophagy, drug resistance and angiogenesis. The mechanisms of SB and its flavonoids, wogonin, baicalein, baicalin, Oroxylin A, and scutellarein, in the treatment of OC, are revealed, such as wogonin inhibits proliferation, induces apoptosis, inhibits invasion and metastasis, and increases the cytotoxicity of the drug. Baicalein also inhibits vascular endothelial growth factor (VEGF) expression etc. Analyzing their advantages and disadvantages in treating OC provides a new perspective on the role of SB and its flavonoids in OC treatment. It serves as a resource for future OC research and development.

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Survivin is critically involved in VEGFR2 signaling-mediated esophageal cancer cell survival

Cited by 11 publications

References 29 publications

The Multiple Roles of the IAP Super-family in cancer

The Multiple Roles of the IAP Super-family in cancer

Hyperthermia in Combination with Emerging Targeted and Immunotherapies as a New Approach in Cancer Treatment

Scutellaria baicalensis Georgi and Their Natural Flavonoid Compounds in the Treatment of Ovarian Cancer: A Review

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